In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2015, No. 13 ( 2015-05), p. 2295-2307
Abstract:
An investigation into the effects of hydrogen bonding on the aggregation tendency of ruthenium compounds [(η 6 ‐ p ‐cymene)Ru(κNHR,κNOH)Cl]Cl {R = Ph ( 1a ), Bn ( 1b )} and [(η 6 ‐ p ‐cymene)Ru(κ 2 NH(2‐ pic ),κNOH)][PF 6 ] 2 ( 1c ), [(η 6 ‐ p ‐cymene)Ru(κNHBn,κNO)Cl] ( 2b ), and [(η 6 ‐ p ‐cymene)Ru(κNBn,κ 2 NO)] ( 3b ) has been performed by means of concentration‐dependence 1 H NMR chemical shift and DOSY experiments. The synthesis and full characterization of new compounds 1c , [(η 6 ‐ p ‐cymene)Ru(κNPh,κ 2 NO)] ( 3a ) and 3b are also reported. The effect of the water‐soluble ruthenium complexes 1a – c on cytotoxicity, cell adhesion, and cell migration of the androgen‐independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type‐I‐collagen, and recovery of monolayer wounds assays, respectively. Interactions of 1a – c with DNA and human serum albumin have also been studied. Together, the properties reported herein suggest that ruthenium compounds 1a – c have considerable potential as anticancer agents against advanced prostate cancer.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2015.13
DOI:
10.1002/ejic.201500097
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475009-0
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