In:
Bioinformatics, Oxford University Press (OUP), Vol. 18, No. 7 ( 2002-07-01), p. 939-948
Abstract:
Classical molecular interaction potentials, in conjunction with other theoretical techniques, are used to analyze the dependence of the binding sites of representative proteins on the bound ligand. It is found that the ligand bound introduces in general small structural perturbations at the binding site of the protein. However, such small structural changes can lead to important alterations in the recognition pattern of the protein. The impact of these findings in docking procedures is discussed. Contact: modesto@luz.bq.ub.es; javier@far1.far.ub.es * To whom correspondence should be addressed.
Type of Medium:
Online Resource
ISSN:
1367-4811
,
1367-4803
DOI:
10.1093/bioinformatics/18.7.939
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2002
detail.hit.zdb_id:
1468345-3
SSG:
12
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