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  • 1
    In: Journal for ImmunoTherapy of Cancer, BMJ, Vol. 4, No. S1 ( 2016-11)
    Type of Medium: Online Resource
    ISSN: 2051-1426
    Language: English
    Publisher: BMJ
    Publication Date: 2016
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  • 2
    Online Resource
    Online Resource
    Brill ; 1991
    In:  Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia Vol. 147, No. 1 ( 1991), p. 150-183
    In: Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia, Brill, Vol. 147, No. 1 ( 1991), p. 150-183
    Abstract: - Martin A. van Bakel, C.B. Wilpert, Südsee Inseln, Völker und Kulturen. Hamburg: Christians, 1987. - Leonard Blussé, Leo Suryadinata, The ethnic Chinese in the Asean states: Bibliographical essays, Singapore: Institute of Southeast Asian studies, 1989. 271 pages. - G. Bos, Cees Koelewijn, Oral literature of the Trio Indians of Surinam, Dordrecht-Providence: Foris, 1987. [Koniniklijk Instituut voor Taal-, Land- en Volkenkunde, Leiden, Caribbean series 6.] 312 pp., Peter Riviere (eds.) - Gary Brana-Shute, Thomas Gibson, Sacrifice and sharing in the Philippine highlands. Religion and society among the Buid of Mindoro, London: Athlone press [Londons school of economics Monographs on social anthropology No 57] , 1986. x, 259 pp. - H.J.M. Claessen, Claude Tardits, Princes et serviteurs du royaume; Cinq études de monarchies africaines. Paris: Societé d’Ethnographie. 1987. 230 pp., maps, figs. - Mary Eggermont-Molenaar, Haijo jan Westra, Gerard Termorshuizen, P.A. Daum; Journalist en romancier van tempo doeloe. Amsterdam: Nijgh & Van Ditmar, 1988. 632 pp. - P.C. Emmer, Selwyn H.H. Carrington, The British West Indies during the American revolution, Dordrecht/Providence: Foris publications, 1988. [Koninklijk Instituut voor Taal-, Land- en Volkenkunde, Caribbean series 8.] 222 pp., bibl. - James J. Fox, R. de Ridder, The Leiden tradition in structural anthropology; Essays in honour of P.E. de Josselin de Jong, Leiden: Brill, 1987., J.A.J. Karremans (eds.) - Silvia W. de Groot, H.U.E. Thoden van Velzen, The great father and the danger; Religious cults, material forces, and the collective fantasies in the world of the Surinamese maroons. Dordrecht (Holland)/Providence (USA): Foris, 1988, 451 pp., W. van Wetering (eds.) - Paul van der Grijp, Frederick Errington, Cultural alternatives and a feminist anthropology; An analysis of culturally constructed gender interests in Papua New Guinea, Cambridge etc.: Cambridge University Press, 1987, 185 pp., Deborah Gewertz (eds.) - Marijke J. Klokke, Annette Claben, Kann die Gupta-Kunst Kalidasas Werke illustrieren? Teil I: Text; Teil II: Abbildungen. Berlin: Dietrich Reimer, 1988. [Marburger Studien zur Afrika- und Asienkunde, Serie B: Asien, Band 11.] 90, XLV pp., 10 figs, 32 pls. - J. Kommers, Michael Young, Malinowski among the Magi. The Natives of Mailu, London and New York: Routledge, 1988. [International library of Anthropology.] viii + 355 pp. - Niels Mulder, Bernhard Dahm, Culture and technological development in Southeast Asia. Baden-Baden: Nomos Verlagsgesellschaft, 1988., Gotz Link (eds.) - Jan Michiel Otto, F. von Benda-Beckmann, Between kinship and the state; Social security and law in developing countries, Dordrecht: Foris, 1988. vii + 495 pp., K. von Benda-Beckmann, E. Casino (eds.) - Nigel Phillips, Rainer Carle, Cultures and societies of North Sumatra, Berlin and Hamburg: Dietrich Reimer, 1987. [Veroffentlichungen des Seminars für Indonesische und Sudseesprachen der Universität Hamburg, Band 19.] 514 pp. - R. De Ridder, James J. Fox, To speak in pairs; Essays on the ritual languages of Eastern Indonesia, Cambridge: Cambridge University Press, 1988. [Cambridge studies in oral literature 15.] xi + 338 pp.; bibl.; ills. - Matthew Schoffeleers, Serge Tcherkezoff, Duel classification reconsidered (Translation by Martin Thom), New York/Paris: Cambridge University Press and Éditions de la Maison des Sciences de l’Homme, 1987, 157 pp. - G.J. Schutte, J.L. Blussé, De dagregisters van het kasteel Zeelandia, Taiwan 1629-1662. Deel I: 1629-1641, uitgegeven door J.L. Blussé, M.E. van Opstall en Ts’ao Yung-ho, met medewerking van Chiang Shu-sheng en W. Milde. [Rijks Geschiedkundige Publicatiën, Grote Serie 195.] ‘s-Gravenhage: Martinus Nijhoff, 1986. xxi + 548 pp., map, indices - H. Steinhauer, Olaf H. Smedal, Lom-Indonesian-English and English-Lom Wordlists, NUSA Linguistic studies of Indonesian and other languages in Indonesia, Vol. 28/29, 1987. viii + 165 pp. - C.L. Voorhoeve, Janet Bateman, Iau verb Morphology. Jakarta: Universitas Katolik Indonesia Atma Jaya, 1986. [Nusa, Linguistic studies of Indonesian and other languages in Indonesia 26.] vi + 78 pp.
    Type of Medium: Online Resource
    ISSN: 0006-2294 , 2213-4379
    Language: Unknown
    Publisher: Brill
    Publication Date: 1991
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  • 3
    In: Nature Genetics, Springer Science and Business Media LLC, Vol. 54, No. 4 ( 2022-04), p. 412-436
    Abstract: Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
    Type of Medium: Online Resource
    ISSN: 1061-4036 , 1546-1718
    RVK:
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
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  • 4
    In: GeroScience, Springer Science and Business Media LLC, Vol. 44, No. 3 ( 2022-06), p. 1641-1655
    Abstract: Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people. Trial registration Clinicaltrials.gov (NCT01038583)
    Type of Medium: Online Resource
    ISSN: 2509-2715 , 2509-2723
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
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  • 5
    In: Autophagy, Informa UK Limited, Vol. 8, No. 4 ( 2012-04), p. 445-544
    Type of Medium: Online Resource
    ISSN: 1554-8627 , 1554-8635
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2012
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  • 6
    In: European Heart Journal - Cardiovascular Pharmacotherapy, Oxford University Press (OUP), ( 2024-04-27)
    Abstract: Icosapent ethyl lowers triglycerides and significantly reduces major adverse cardiovascular events (MACE), though treatment effects may vary between individuals. This study aimed to determine the relative and absolute effects of icosapent ethyl on MACE according to baseline cardiovascular disease (CVD) risk in patients with atherosclerotic cardiovascular disease (ASCVD). Methods and Results Participants from the Reduction of Cardiovascular Events with Icosapent Ethyl—Intervention Trial (REDUCE-IT) with ASCVD were included (n = 5785). The primary outcome was 3-point MACE, i.e. non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death. Baseline 5-year risk of MACE was estimated using the European Society of Cardiology (ESC) guideline-recommended SMART2 risk score. Modification of the relative treatment effects of icosapent ethyl by baseline risk was assessed using Cox proportional hazards models, including a treatment-by-risk interaction. Next, treatment effects were assessed stratified by quartiles of baseline risk. During a median follow-up of 4.8 years (interquartile range 3.2–5.3), MACE occurred in 361 vs. 489 patients in the icosapent ethyl vs. placebo group [95% confidence interval (CI)]; hazard ratio (HR) 0.72 (0.63–0.82), absolute risk reduction (ARR) 4.4% (2.6–6.2%), number needed to treat (NNT) 23 (16–38), and 5-year Kaplan-Meier estimated cumulative incidence reduction (CIR) 5.7% (3.5–7.9%). Icosapent ethyl significantly reduced MACE in all risk quartiles, with an HR (95% CI) of 0.62 (0.43–0.88), 0.66 (0.48–0.92), 0.69 (0.53–0.90), and 0.78 (0.63–0.96), respectively (P for treatment-by-risk interaction = 0.106). The ARR (95% CI) increased across risk quartiles, i.e. was 3.9% (1.0–6.8%), 4.3% (1.2–7.3%), 5.1% (1.4–8.7%), and 5.6% (1.3–10.0%), respectively. This translates to NNTs (95% CI) of 26 (15–98), 24 (14–84), 20 (11–70), and 18 (10–77). The 5-year CIR (95% CI) was 4.8% (1.3–8.2%), 5.0% (1.3–8.7%), 6.1% (1.7–10.5%), and 7.7% (2.3–13.2%), respectively. Consistent results were obtained for 5-point MACE, additionally including coronary revascularization and unstable angina. Conclusion Among patients with ASCVD and elevated triglyceride levels, icosapent ethyl significantly reduces the risk of MACE irrespective of baseline CVD risk, though absolute benefits are largest for patients at the highest risk.
    Type of Medium: Online Resource
    ISSN: 2055-6837 , 2055-6845
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2024
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  • 7
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 79, No. 9 ( 2012-08-28), p. 878-882
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
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  • 8
    In: JAMA Neurology, American Medical Association (AMA), Vol. 80, No. 12 ( 2023-12-01), p. 1353-
    Abstract: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH along the AD continuum is reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors. Objective To estimate the associations of neurodegeneration and parenchymal and vessel amyloidosis with WMH accumulation and investigate whether systemic vascular risk is associated with WMH beyond these AD-intrinsic processes. Design, Setting, and Participants This cohort study used data from 3 longitudinal cohort studies conducted in tertiary and community-based medical centers—the Dominantly Inherited Alzheimer Network (DIAN; February 2010 to March 2020), the Alzheimer’s Disease Neuroimaging Initiative (ADNI; July 2007 to September 2021), and the Harvard Aging Brain Study (HABS; September 2010 to December 2019). Main Outcome and Measures The main outcomes were the independent associations of neurodegeneration (decreases in gray matter volume), parenchymal amyloidosis (assessed by amyloid positron emission tomography), and vessel amyloidosis (evidenced by cerebral microbleeds [CMBs]) with cross-sectional and longitudinal WMH. Results Data from 3960 MRI sessions among 1141 participants were included: 252 pathogenic variant carriers from DIAN (mean [SD] age, 38.4 [11.2] years; 137 [54%] female), 571 older adults from ADNI (mean [SD] age, 72.8 [7.3] years; 274 [48%] female), and 318 older adults from HABS (mean [SD] age, 72.4 [7.6] years; 194 [61%] female). Longitudinal increases in WMH volume were greater in individuals with CMBs compared with those without (DIAN: t  = 3.2 [ P  = .001]; ADNI: t  = 2.7 [ P  = .008]), associated with longitudinal decreases in gray matter volume (DIAN: t  = −3.1 [ P  = .002]; ADNI: t  = −5.6 [ P   & amp;lt; .001]; HABS: t  = −2.2 [ P  = .03]), greater in older individuals (DIAN: t  = 6.8 [ P   & amp;lt; .001]; ADNI: t  = 9.1 [ P   & amp;lt; .001]; HABS: t  = 5.4 [ P   & amp;lt; .001]), and not associated with systemic vascular risk (DIAN: t  = 0.7 [ P  = .40]; ADNI: t  = 0.6 [ P  = .50]; HABS: t  = 1.8 [ P  = .06]) in individuals with ADAD and LOAD after accounting for age, gray matter volume, CMB presence, and amyloid burden. In older adults without CMBs at baseline, greater WMH volume was associated with CMB development during longitudinal follow-up (Cox proportional hazards regression model hazard ratio, 2.63; 95% CI, 1.72-4.03; P   & amp;lt; .001). Conclusions and Relevance The findings suggest that increased WMH volume in AD is associated with neurodegeneration and parenchymal and vessel amyloidosis but not with elevated systemic vascular risk. Additionally, increased WMH volume may represent an early sign of vessel amyloidosis preceding the emergence of CMBs.
    Type of Medium: Online Resource
    ISSN: 2168-6149
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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  • 9
    In: Circulation: Cardiovascular Interventions, Ovid Technologies (Wolters Kluwer Health), Vol. 17, No. 6 ( 2024-06)
    Abstract: ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) did not find an overall reduction in cardiovascular events with an initial invasive versus conservative management strategy in chronic coronary disease; however, there were conservative strategy participants who underwent invasive coronary angiography early postrandomization (within 6 months). Identifying factors associated with angiography in conservative strategy participants will inform clinical decision-making in patients with chronic coronary disease. METHODS: Factors independently associated with angiography performed within 6 months of randomization were identified using Fine and Gray proportional subdistribution hazard models, including demographics, region of randomization, medical history, risk factor control, symptoms, ischemia severity, coronary anatomy based on protocol-mandated coronary computed tomography angiography, and medication use. RESULTS: Among 2591 conservative strategy participants, angiography within 6 months of randomization occurred in 8.7% (4.7% for a suspected primary end point event, 1.6% for persistent symptoms, and 2.6% due to protocol nonadherence) and was associated with the following baseline characteristics: enrollment in Europe versus Asia (hazard ratio [HR], 1.81 [95% CI, 1.14–2.86] ), daily and weekly versus no angina (HR, 5.97 [95% CI, 2.78–12.86] and 2.63 [95% CI, 1.51–4.58] , respectively), poor to fair versus good to excellent health status (HR, 2.02 [95% CI, 1.23–3.32]) assessed with Seattle Angina Questionnaire, and new/more frequent angina prerandomization (HR, 1.80 [95% CI, 1.34–2.40] ). Baseline low-density lipoprotein cholesterol 〈 70 mg/dL was associated with a lower risk of angiography (HR, 0.65 [95% CI, 0.46–0.91) but not baseline ischemia severity nor the presence of multivessel or proximal left anterior descending artery stenosis 〉 70% on coronary computed tomography angiography. CONCLUSIONS: Among ISCHEMIA participants randomized to the conservative strategy, angiography within 6 months of randomization was performed in 〈 10% of patients. It was associated with frequent or increasing baseline angina and poor quality of life but not with objective markers of disease severity. Well-controlled baseline low-density lipoprotein cholesterol was associated with a reduced likelihood of angiography. These findings point to the importance of a comprehensive assessment of symptoms and a review of guideline-directed medical therapy goals when deciding the initial treatment strategy for chronic coronary disease. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01471522.
    Type of Medium: Online Resource
    ISSN: 1941-7640 , 1941-7632
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
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  • 10
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. 23 ( 2021-12-07), p. 1845-1855
    Abstract: Despite advances in surgery and pharmacotherapy, there remains significant residual ischemic risk after coronary artery bypass grafting surgery. Methods: In REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial), a multicenter, placebo-controlled, double-blind trial, statin-treated patients with controlled low-density lipoprotein cholesterol and mild to moderate hypertriglyceridemia were randomized to 4 g daily of icosapent ethyl or placebo. They experienced a 25% reduction in risk of a primary efficacy end point (composite of cardiovascular death, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina) and a 26% reduction in risk of a key secondary efficacy end point (composite of cardiovascular death, myocardial infarction, or stroke) when compared with placebo. The current analysis reports on the subgroup of patients from the trial with a history of coronary artery bypass grafting. Results: Of the 8179 patients randomized in REDUCE-IT, a total of 1837 (22.5%) had a history of coronary artery bypass grafting, with 897 patients randomized to icosapent ethyl and 940 to placebo. Baseline characteristics were similar between treatment groups. Randomization to icosapent ethyl was associated with a significant reduction in the primary end point (hazard ratio [HR], 0.76 [95% CI, 0.63–0.92] ; P =0.004), in the key secondary end point (HR, 0.69 [95% CI, 0.56–0.87]; P =0.001), and in total (first plus subsequent or recurrent) ischemic events (rate ratio, 0.64 [95% CI, 0.50–0.81]; P =0.0002) compared with placebo. This yielded an absolute risk reduction of 6.2% (95% CI, 2.3%–10.2%) in first events, with a number needed to treat of 16 (95% CI, 10–44) during a median follow-up time of 4.8 years. Safety findings were similar to the overall study: beyond an increased rate of atrial fibrillation/flutter requiring hospitalization for at least 24 hours (5.0% vs 3.1%; P =0.03) and a nonsignificant increase in bleeding, occurrences of adverse events were comparable between groups. Conclusions: In REDUCE-IT patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl was associated with significant reductions in first and recurrent ischemic events. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01492361.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
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