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  • 1
    Online Resource
    Online Resource
    A new insight on feasibility of pre-, pro-, and synbiotics-based therapies in Alzheimer’s disease
    Medknow ; 2022
    In:  Journal of Reports in Pharmaceutical Sciences Vol. 11, No. 2 ( 2022), p. 141-
    Details
    In: Journal of Reports in Pharmaceutical Sciences, Medknow, Vol. 11, No. 2 ( 2022), p. 141-
    Type of Medium: Online Resource
    ISSN: 2322-1232
    URL: Article
    DOI: 10.4103/jrptps.JRPTPS_170_21
    Language: English
    Publisher: Medknow
    Publication Date: 2022
    detail.hit.zdb_id: 2807136-0
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  • 2
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    Anti-proliferative activity of Artemisia marschalliana on cancerous cell lines
    Springer Science and Business Media LLC ; 2023
    In:  BMC Complementary Medicine and Therapies Vol. 23, No. 1 ( 2023-04-14)
    Details
    In: BMC Complementary Medicine and Therapies, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-04-14)
    Abstract: The genus Artemisia of the Asteraceae family has different species that are used in the treatment of a wide range of diseases, including cancers due to the presence of valuable compounds and important medicinal properties. Various studies on the anti-tumor effect of different species of Artemisia have proven the cytotoxic properties of these plants in cancer treatment, and several anti-cancer compounds of this genus have been purified. Objective The objective of this study was to investigate the cytotoxicity and related mortality mechanisms of Artemisia marschalliana essential oil and extracts. Methods The essential oil and various extracts of Artemisia marschalliana were elicited using a Soxhlet extractor. Anti-cancer to anti-proliferative activity as MTT assay is measuring cancerous and non-cancerous cell viability. In the next step, the strongest extract fractions were obtained by using the vacuum liquid chromatography method. Flow cytometry was applied to identify the mechanism of cell death, and a Real-time polymerase chain reaction test of apoptosis genes, which encode apoptosis-regulating proteins, was measured to confirm the flow cytometry results. Results The strongest extract belonged to dichloromethane extract 60% fraction of the extract on breast cancer cells and 80% fraction on liposarcoma cancer cells showed the most cytotoxicity within 48 h, while, the fractions did not notable cytotoxicity of non-cancerous cells cell. Flow cytometry analysis illustrated the mentioned extract and its fractions kill cancer cell lines through the apoptosis mechanism. Our findings confirmed the flow cytometry results. In addition, the essential oil of Artemisia marschalliana showed a considerable cytotoxic property. Conclusion Dichloromethane extract of Artemisia marschalliana shoot and its 60 and 80% fraction selectively inhibited the growth of cancer cells by inducing the apoptosis mechanism. Regarding obtained results, 60 and 80% fractions of dichloromethane extract can be a good candidate for future studies in the field of identification and separation of pure cytotoxic compounds.
    Type of Medium: Online Resource
    ISSN: 2662-7671
    URL: Article
    DOI: 10.1186/s12906-023-03887-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 3037610-5
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  • 3
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    Halomonas urmiana sp. nov., a moderately halophilic bacterium isolated from Urmia Lake in Iran
    Microbiology Society ; 2020
    In:  International Journal of Systematic and Evolutionary Microbiology Vol. 70, No. 4 ( 2020-04-01), p. 2254-2260
    Details
    In: International Journal of Systematic and Evolutionary Microbiology, Microbiology Society, Vol. 70, No. 4 ( 2020-04-01), p. 2254-2260
    Abstract: In the course of screening halophilic bacteria in Urmia Lake in Iran, which is being threatened by dryness, a novel Gram-negative, moderately halophilic, heterotrophic and short rod-shaped bacteria was isolated and characterized. The bacterium was isolated from a water specimen and designated as TBZ3 T . Colonies were found to be creamy yellow, with catalase- and oxidase-positive activities. The growth of strain TBZ3 T was observed to be at 10–45 °C (optimum, 30 °C), at pH 6.0–9.0 (optimum, pH 7.0) and in the presence of 0.5–20 % (w/v) NaCl (optimum, 7.5 %). Strain TBZ3 T contained C 16 : 0 , cyclo-C 19 : 0   ω8 c , summed feature 3 (comprising C 16 : 1  ω 7 c and/or C 16 : 1  ω 6 c ) and summed feature 8 (comprising C 18 : 1  ω 7 c and/or C 18 : 1  ω 6 c ) as major fatty acids and ubiquinone-9 as the only respiratory isoprenoid quinone. Diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, glycolipid, unidentified phospholipid and unidentified polar lipids were detected as the major polar lipids. Strain TBZ3 T was found to be most closely related to Halomonas saccharevitans AJ275 T , Halomonas denitrificans M29 T and Halomonas sediminicola CPS11 T with the 16S rRNA gene sequence similarities of 98.93, 98.15 and 97.60 % respectively and in phylogenetic analysis strain TBZ3 T grouped with Halomonas saccharevitans AJ275 T contained within a large cluster within the genus Halomonas . Based on phenotypic, chemotaxonomic and molecular properties, strain TBZ3 T represents a novel species of the Halomonas genus, for which the name Halomonas urmiana sp. nov. is proposed. The type strain is TBZ3 T (=DSM 22871 T =LMG 25416 T ).
    Type of Medium: Online Resource
    ISSN: 1466-5026 , 1466-5034
    URL: Article
    DOI: 10.1099/ijsem.0.004005
    Language: English
    Publisher: Microbiology Society
    Publication Date: 2020
    detail.hit.zdb_id: 215062-1
    detail.hit.zdb_id: 2056611-6
    SSG: 12
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  • 4
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    Halomonas tabrizica sp. nov., a novel moderately halophilic bacterium isolated from Urmia Lake in Iran
    Springer Science and Business Media LLC ; 2018
    In:  Antonie van Leeuwenhoek Vol. 111, No. 7 ( 2018-7), p. 1139-1148
    Details
    In: Antonie van Leeuwenhoek, Springer Science and Business Media LLC, Vol. 111, No. 7 ( 2018-7), p. 1139-1148
    Type of Medium: Online Resource
    ISSN: 0003-6072 , 1572-9699
    URL: Article
    DOI: 10.1007/s10482-018-1018-8
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 1478112-8
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Curcumin nanoformulations: Beneficial nanomedicine against cancer
    Wiley ; 2022
    In:  Phytotherapy Research Vol. 36, No. 3 ( 2022-03), p. 1156-1181
    Details
    In: Phytotherapy Research, Wiley, Vol. 36, No. 3 ( 2022-03), p. 1156-1181
    Abstract: Curcumin is a phytochemical achieved from the plant turmeric. It is extensively utilized for the treatment of several types of diseases such as cancers. Nevertheless, its efficiency has been limited because of rapid metabolism, low bioavailability, poor water solubility, and systemic elimination. Scientists have tried to solve these problems by exploring novel drug delivery systems such as lipid‐based nanoparticles (NPs) (e.g., solid lipid NPs, nanostructured lipid carriers, and liposomes), polymeric NPs, micelles, nanogels, cyclodextrin, gold, and mesoporous silica NPs. Among these, liposomes have been the most expansively studied. This review mainly focuses on the different curcumin nanoformulations and their use in cancer therapy in vitro, in vivo, and clinical studies. Despite the development of curcumin‐containing NPs for the treatment of cancer, potentially serious side effects, including interactions with other drugs, some toxicity aspects of NPs may occur that require more high‐quality investigations to firmly establish the clinical efficacy.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v36.3
    DOI: 10.1002/ptr.7389
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 6
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    Application of Collagen and Mesenchymal Stem Cells in Regenerative Dentistry
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Stem Cell Research & Therapy Vol. 17, No. 7 ( 2022-10), p. 606-620
    Details
    In: Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd., Vol. 17, No. 7 ( 2022-10), p. 606-620
    Abstract: Collagen is an important macromolecule of extracellular matrix (ECM) in bones, teeth, and temporomandibular joints. Mesenchymal stem cells (MSCs) interact with the components of the ECM such as collagen, proteoglycans, glycosaminoglycans (GAGs), and several proteins on behalf of variable matrix elasticity and bioactive cues. Synthetic collagen-based biomaterials could be effective scaffolds for regenerative dentistry applications due to mimicking of host tissues’ ECM. These biomaterials are biocompatible, biodegradable, readily available, and non-toxic to cells whose capability promotes cellular response and wound healing in the craniofacial region. Collagen could incorporate other biomolecules to induce mineralization in calcified tissues like bone and tooth. Moreover, the addition of these molecules or other polymers to collagen-based biomaterials could enhance mechanical properties, which is important in load-bearing areas such as the mandible. A literature review was performed via a reliable internet database (mainly PubMed) based on MeSH keywords. This review first describes the properties of collagen as a key protein in the structure of hard tissues. Then, it introduces different types of collagens, the correlation between collagen and MSCs, and the methods used to modify collagen in regenerative dentistry, including recent progression on the regeneration of periodontium, dentin-pulp complex, and temporomandibular joint by applying collagen. The prospects and challenges of collagen-based biomaterials in the craniofacial region are pointd out.
    Type of Medium: Online Resource
    ISSN: 1574-888X
    URL: Article
    DOI: 10.2174/1574888X17666211220100521
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 7
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    Modulation of the Immune System Mechanisms using Probiotic Bacteria in Allergic Diseases: Focus on Allergic Retinitis and Food Allergies
    Bentham Science Publishers Ltd. ; 2023
    In:  Recent Advances in Inflammation & Allergy Drug Discovery Vol. 17 ( 2023-10-11)
    Details
    In: Recent Advances in Inflammation & Allergy Drug Discovery, Bentham Science Publishers Ltd., Vol. 17 ( 2023-10-11)
    Abstract: Allergic illnesses occur when an organism's immune system is excessively responsive to certain antigens, such as those that are presented in the environment. Some people suffer from a wide range of immune system-related illnesses including allergic rhinitis, asthma, food allergies, hay fever, and even anaphylaxis. Immunotherapy and medications are frequently used to treat allergic disorders. The use of probiotics in bacteriotherapy has lately gained interest. Probiotics are essential to human health by modulating the gut microbiota in some ways. Due to probiotics' immunomodulatory properties present in the gut microbiota of all animals, including humans, these bacterial strains can prevent a wide variety of allergic disorders. Probiotic treatment helps allergy patients by decreasing inflammatory cytokines and enhancing intestinal permeability, which is important in the battle against allergy. By altering the balance of Th1 and Th2 immune responses in the intestinal mucosa, probiotics can heal allergic disorders. Numerous studies have shown a correlation between probiotics and a reduced risk of allergy disorders. A wide range of allergic disorders, including atopic dermatitis, asthma, allergic retinitis and food allergies has been proven to benefit from probiotic bacteria. Therefore, the use of probiotics in the treatment of allergic diseases offers a promising perspective. Considering that probiotic intervention in the treatment of diseases is a relatively new field of study, more studies in this regard seem necessary
    Type of Medium: Online Resource
    ISSN: 2772-2708
    URL: Article
    DOI: 10.2174/0127722708246899230928080651
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 8
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    Quercetin as a Novel Therapeutic Approach for Lymphoma
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-8-2), p. 1-15
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-8-2), p. 1-15
    Abstract: Lymphoma is a name for malignant diseases of the lymphatic system including Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Although several approaches are used for the treatment of these diseases, some of them are not successful and have serious adverse effects. Therefore, other effective treatment methods might be interesting. Studies have indicated that plant ingredients play a key role in treating several diseases. Some plants have already shown a potential therapeutic effect on many malignant diseases. Quercetin is a flavonoid found in different plants and could be useful in the treatment of different malignant diseases. Quercetin has its antimalignant effects through targeting main survival pathways activated in tumor cells. In vitro/in vivo experimental studies have demonstrated that quercetin possesses a cytotoxic effect on lymphoid cancer cells. Regardless of the optimum results that have been obtained from both in vitro/in vivo studies, few clinical studies have analyzed the antitumor effects of quercetin in lymphoid cancers. Thus, it seems that more clinical studies should introduce quercetin as a therapeutic, alone or in combination with other chemotherapy agents. Here, in this study, we reviewed the anticancer effects of quercetin and highlighted the potential therapeutic effects of quercetin in various types of lymphoma.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/3157867
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 9
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    Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-9-15)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-9-15)
    Abstract: Neuropsychiatric diseases are a group of disorders that cause significant morbidity and disability. The symptoms of psychiatric disorders include anxiety, depression, eating disorders, autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, and conduct disorder. Various medicinal plants are frequently used as therapeutics in traditional medicine in different parts of the world. Nowadays, using medicinal plants as an alternative medication has been considered due to their biological safety. Despite the wide range of medications, many patients are unable to tolerate the side effects and eventually lose their response. By considering the therapeutic advantages of medicinal plants in the case of side effects, patients may prefer to use them instead of chemical drugs. Today, the use of medicinal plants in traditional medicine is diverse and increasing, and these plants are a precious heritage for humanity. Investigation about traditional medicine continues, and several studies have indicated the basic pharmacology and clinical efficacy of herbal medicine. In this article, we discuss five of the most important and common psychiatric illnesses investigated in various studies along with conventional therapies and their pharmacological therapies. For this comprehensive review, data were obtained from electronic databases such as MedLine/PubMed, Science Direct, Web of Science, EMBASE, DynaMed Plus, ScienceDirect, and TRIP database. Preclinical pharmacology studies have confirmed that some bioactive compounds may have beneficial therapeutic effects in some common psychiatric disorders. The mechanisms of action of the analyzed biocompounds are presented in detail. The bioactive compounds analyzed in this review are promising phytochemicals for adjuvant and complementary drug candidates in the pharmacotherapy of neuropsychiatric diseases. Although comparative studies have been carefully reviewed in the preclinical pharmacology field, no clinical studies have been found to confirm the efficacy of herbal medicines compared to FDA-approved medicines for the treatment of mental disorders. Therefore, future clinical studies are needed to accelerate the potential use of natural compounds in the management of these diseases.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2022.926607
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 10
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    The role of circadian gene timeless in gastrointestinal cancers
    Elsevier BV ; 2023
    In:  Gene Reports Vol. 30 ( 2023-03), p. 101722-
    Details
    In: Gene Reports, Elsevier BV, Vol. 30 ( 2023-03), p. 101722-
    Type of Medium: Online Resource
    ISSN: 2452-0144
    URL: Article
    DOI: 10.1016/j.genrep.2022.101722
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2844888-1
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