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  • 1
    Online Resource
    Online Resource
    COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study
    Elsevier BV ; 2021
    In:  The Lancet Rheumatology Vol. 3, No. 6 ( 2021-06), p. e419-e426
    Details
    In: The Lancet Rheumatology, Elsevier BV, Vol. 3, No. 6 ( 2021-06), p. e419-e426
    Type of Medium: Online Resource
    ISSN: 2665-9913
    URL: Article
    DOI: 10.1016/S2665-9913(21)00059-X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
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  • 2
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    Sensitivity of mineral dust concentrations to the model size distribution accuracy
    American Geophysical Union (AGU) ; 2007
    In:  Journal of Geophysical Research: Atmospheres Vol. 112, No. D10 ( 2007-05-27)
    Details
    In: Journal of Geophysical Research: Atmospheres, American Geophysical Union (AGU), Vol. 112, No. D10 ( 2007-05-27)
    Abstract: Evaluating the impacts of atmospheric dust on marine ecosystems and climate requires the use of three‐dimensional transport models including a size‐resolved bins scheme to describe the evolution of the particle size distribution. Recently, Forêt et al. (2006) proposed an alternative size bins scheme to better account for the physical size‐dependent processes such as dry deposition. This paper evaluates the benefit of using this new bin scheme in three‐dimensional transport models. This is achieved by performing a one‐and‐a‐half month simulation with the CHIMERE‐DUST model forced by the Mesoscale Model, Version 5 (MM5)/National Center for Environmental Prediction (NCEP) analysis fields, for an area covering the northern Atlantic Sea and the western Africa. Compared to a reference run performed using a large number of size bins (40), our results show that the size bins scheme proposed by Forêt et al. (2006) reduces at least by a factor of 2 the numerical errors on the simulated concentrations compared to the classical isolog bins scheme for the same number of size bins. However, with this new bins scheme requiring to define the bins according to a dry deposition velocity corresponding to a given friction velocity, we examine the errors associated to this constraint.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/2006JD007766
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2007
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    SSG: 16,13
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  • 3
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    RC beams strengthened with composite material: a limit analysis approach and experimental study
    Elsevier BV ; 2003
    In:  Composite Structures Vol. 59, No. 4 ( 2003-3), p. 467-472
    Details
    In: Composite Structures, Elsevier BV, Vol. 59, No. 4 ( 2003-3), p. 467-472
    Type of Medium: Online Resource
    ISSN: 0263-8223
    URL: Article
    DOI: 10.1016/S0263-8223(02)00286-6
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2003
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  • 4
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    Calculation of the dynamic responses of a railway track on a non-uniform foundation
    SAGE Publications ; 2023
    In:  Journal of Vibration and Control Vol. 29, No. 15-16 ( 2023-08), p. 3544-3553
    Details
    In: Journal of Vibration and Control, SAGE Publications, Vol. 29, No. 15-16 ( 2023-08), p. 3544-3553
    Abstract: The dynamic response of a railway track has been investigated by analytical or numerical models. When rail supports (sleepers) or foundation contain defects, the damage reduces stiffness and the track becomes non-uniform. This paper presents a new analytical model to calculate the dynamic responses of a railway track on a non-uniform foundation. In this model, the rail is considered as an infinite beam resting on equidistant supports and subjected to moving forces. The sleepers responses are stable provided that there is a sufficiently large distance between the applied forces and the defective area. By combining this condition and the dynamic equation of the beam, we can deduce a relation between the reaction forces in the supports and the displacement of the beam. This relation does not depend on supports and foundation behaviors. Hence, we can calculate the dynamic response of the track by using the constitutive laws of the supports. The responses can be obtained finally with direct or with iterative techniques. The numerical examples show that a defective zone causes an increase in the rail displacement at the defective zone and overloads the neighbor supports.
    Type of Medium: Online Resource
    ISSN: 1077-5463 , 1741-2986
    URL: Article
    DOI: 10.1177/10775463221099353
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
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  • 5
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    Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle
    American Society for Microbiology ; 2019
    In:  Journal of Virology Vol. 93, No. 7 ( 2019-04)
    Details
    In: Journal of Virology, American Society for Microbiology, Vol. 93, No. 7 ( 2019-04)
    Abstract: The recently discovered influenza D virus (IDV) of the Orthomyxoviridae family has been detected in swine and ruminants with a worldwide distribution. Cattle are considered to be the primary host and reservoir, and previous studies suggested a tropism of IDV for the upper respiratory tract and a putative role in the bovine respiratory disease complex. This study aimed to characterize the pathogenicity of IDV in naive calves as well as the ability of this virus to transmit by air. Eight naive calves were infected by aerosol with a recent French isolate, D/bovine/France/5920/2014. Results show that IDV replicates not only in the upper respiratory tract but also in the lower respiratory tract (LRT), inducing moderate bronchopneumonia with restricted lesions of interstitial pneumonia. Inoculation was followed by IDV-specific IgG1 production as early as 10 days postchallenge and likely both Th1 and Th2 responses. Study of the innate immune response in the LRT of IDV-infected calves indicated the overexpression of pathogen recognition receptors and of chemokines CCL2, CCL3, and CCL4, but without overexpression of genes involved in the type I interferon pathway. Finally, virological examination of three aerosol-sentinel animals, housed 3 m apart from inoculated calves (and thus subject to infection by aerosol transmission), and IDV detection in air samples collected in different areas showed that IDV can be airborne transmitted and infect naive contact calves on short distances. This study suggests that IDV is a respiratory virus with moderate pathogenicity and probably a high level of transmission. It consequently can be considered predisposing to or a cofactor of respiratory disease. IMPORTANCE Influenza D virus (IDV), a new genus of the Orthomyxoviridae family, has a broad geographical distribution and can infect several animal species. Cattle are so far considered the primary host for IDV, but the pathogenicity and the prevalence of this virus are still unclear. We demonstrated that under experimental conditions (in a controlled environment and in the absence of coinfecting pathogens), IDV is able to cause mild to moderate disease and targets both the upper and lower respiratory tracts. The virus can transmit by direct as well as aerosol contacts. While this study evidenced overexpression of pathogen recognition receptors and chemokines in the lower respiratory tract, IDV-specific IgG1 production as early as 10 days postchallenge, and likely both Th1 and Th2 responses, further studies are warranted to better understand the immune responses triggered by IDV and its role as part of the bovine respiratory disease complex.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    URL: Article
    DOI: 10.1128/JVI.01853-18
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2019
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  • 6
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    Stress analysis in a classical double lap, adhesively bonded joint with a layerwise model
    Elsevier BV ; 2009
    In:  International Journal of Adhesion and Adhesives Vol. 29, No. 1 ( 2009-1), p. 67-76
    Details
    In: International Journal of Adhesion and Adhesives, Elsevier BV, Vol. 29, No. 1 ( 2009-1), p. 67-76
    Type of Medium: Online Resource
    ISSN: 0143-7496
    URL: Article
    DOI: 10.1016/j.ijadhadh.2008.01.004
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
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  • 7
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    Understanding the Simulated Ammonia Increasing Trend from 2008 to 2015 over Europe with CHIMERE and Comparison with IASI Observations
    MDPI AG ; 2022
    In:  Atmosphere Vol. 13, No. 7 ( 2022-07-13), p. 1101-
    Details
    In: Atmosphere, MDPI AG, Vol. 13, No. 7 ( 2022-07-13), p. 1101-
    Abstract: The objective of this study is to assess and understand the NH3 recent trends and to identify the key components driving its concentrations. We have simulated the seasonal cycle, the interannual variability, and the trends in NH3 vertical column densities (VCD) from 2008 to 2015 over Europe, with the CHIMERE regional chemistry–transport model. We have also confronted the simulations against the Infrared Atmospheric Sounding Interferometer (IASI) satellite observations. IASI often shows a strong maximum in summer in addition to the spring peak, whereas CHIMERE only shows a slight peak in summer some years. This result could point to a misrepresentation of the temporal profile of the NH3 emissions, i.e., to missing emission sources during summertime either due to more than expected fertilizer use or to increased volatilization under warmer conditions. The simulated NH3 VCDs present an increasing trend over continental Europe (+2.7 ± 1.0 %/yr) but also at the national scale for Spain, Germany, UK, France, and Poland. Sensitivity tests indicate that these simulated positive trends are mainly due to (i) the trends in NH3 emissions, found heterogeneous in the EMEP NH3 emissions with strong disparities depending on the country, and (ii) the negative trends in NOx and SOx emissions. The impact of reductions in NO2 and SO2 emissions on NH3 concentrations should therefore be taken into account in future policies. This simulated NH3 VCD increase at the European scale is confirmed by IASI-v3R satellite observations in spring and summer, when ammonia emissions strongly contribute to the annual budget in accordance with crop requirements. Nevertheless, there are remaining differences about the significance and magnitude between the simulated and observed trends at the national scale, and it warrants further investigation.
    Type of Medium: Online Resource
    ISSN: 2073-4433
    URL: Article
    DOI: 10.3390/atmos13071101
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
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    SSG: 23
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  • 8
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    État et perspectives de la recherche dans le domaine de la qualité de l’air
    CAIRN ; 2019
    In:  Annales des Mines - Responsabilité et environnement Vol. N° 96, No. 4 ( 2019-9-19), p. 104-106
    Details
    In: Annales des Mines - Responsabilité et environnement, CAIRN, Vol. N° 96, No. 4 ( 2019-9-19), p. 104-106
    Type of Medium: Online Resource
    ISSN: 1268-4783
    URL: Article
    DOI: 10.3917/re1.096.0104
    Language: French
    Publisher: CAIRN
    Publication Date: 2019
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  • 9
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    Influence of Non-Homogeneous Foundations on the Dynamic Responses of Railway Sleepers
    World Scientific Pub Co Pte Ltd ; 2021
    In:  International Journal of Structural Stability and Dynamics Vol. 21, No. 01 ( 2021-01), p. 2150002-
    Details
    In: International Journal of Structural Stability and Dynamics, World Scientific Pub Co Pte Ltd, Vol. 21, No. 01 ( 2021-01), p. 2150002-
    Abstract: In a railway track, the sleeper’s responses on a non-homogeneous foundation have been investigated by researchers focusing on the foundation behavior along the rails. However, the foundation can also vary along the sleeper length, particularly when the track is newly tamped. The foundation at the sleeper center is often weaker than those under the rails and this non-homogeneity directly affects the sleeper responses. This paper presents a new model to calculate the influence of such foundations on the dynamic responses of the railway sleepers. This model is developed by combining a finite element model for the sleepers and foundation and a model of periodically supported beams subjected to moving loads for the rails. In this paper, the foundation contains three parts with different mechanical behaviors. The sleeper’s responses can be calculated by transforming the finite-element dynamic stiffness matrix to the one considering the boundary conditions and the relation between the rail seat forces and rail displacements governed by the beam model. This method reduces all the degrees of freedom of the railway track to its one period which gives a substantial reduction in computational time. The numerical applications show that the more homogeneous (so-called consolidated) the foundation is, the larger the sleeper strain is at its center. This result shows the potential application of the sleeper responses to estimating the consolidation level of the foundation.
    Type of Medium: Online Resource
    ISSN: 0219-4554 , 1793-6764
    URL: Article
    DOI: 10.1142/S0219455421500024
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2021
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  • 10
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    Response of a periodically supported beam on a nonlinear foundation subjected to moving loads
    Springer Science and Business Media LLC ; 2016
    In:  Nonlinear Dynamics Vol. 86, No. 2 ( 2016-10), p. 953-961
    Details
    In: Nonlinear Dynamics, Springer Science and Business Media LLC, Vol. 86, No. 2 ( 2016-10), p. 953-961
    Type of Medium: Online Resource
    ISSN: 0924-090X , 1573-269X
    URL: Article
    DOI: 10.1007/s11071-016-2936-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2012600-1
    SSG: 11
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