In:
European Journal of Biochemistry, Wiley, Vol. 235, No. 3 ( 1996-02), p. 585-592
Abstract:
The methylation of cytosine residues in CpG dinucleotides of eukaryotic DNA is an important mechanism for the regulation of gene expression. Higher plants have a high content of methylated cytosine residues in CpG as well as CpNpG sites, and experimental evidence suggests a role in gene expression for DNA methylation. In this article, we describe a tobacco nuclear protein whose binding to various DNA sequences is positively correlated with the CpG density of the probes. This protein, CpG‐binding protein 1 (CGBP‐1), has reduced affinity for DNA when the CpG sites are methylated. Ribonuclease treatment also reduces the formation of the CGBP‐1 complex. The binding characteristics of CGBP‐1 make it an interesting protein with respect to methylation‐mediated gene expression in p1 nts.
Type of Medium:
Online Resource
ISSN:
0014-2956
,
1432-1033
DOI:
10.1111/ejb.1996.235.issue-3
DOI:
10.1111/j.1432-1033.1996.00585.x
Language:
English
Publisher:
Wiley
Publication Date:
1996
detail.hit.zdb_id:
1398347-7
detail.hit.zdb_id:
2172518-4
SSG:
12
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