In:
Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 42, No. 6 ( 2016-06), p. 618-624
Abstract:
To investigate whether serum levels of neopterin and inflammatory markers including C‐reactive protein (CRP), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and oxidative status indicators were altered in patients with hyperemesis gravidarum (HG) compared to asymptomatic pregnant women. Methods This cross‐sectional study was performed including 30 pregnant women with HG (mean age: 30.67 ± 6.68) and 30 asymptomatic pregnant women (mean age: 28.00 ± 5.30). Demographic features, obstetric history, and the Pregnancy Unique Quantification of Emesis/Nausea (PUQE) index were noted. Complete blood count, serum biochemical assay and measurement of CRP, TNF‐α, IL‐6, total antioxidant status and total oxidative status (TOS) levels were taken and compared between groups. Results White blood cell count ( P = 0.013), platelet count ( P = 0.015), TOS ( P 〈 0.001), and PUQE score ( P 〈 0.001) were remarkably higher in HG pregnancies. On the other hand, serum levels of lactate dehydrogenase, ( P 〈 0.001), sodium ( P 〈 0.001), potassium ( P 〈 0.001), chloride ( P 〈 0.001) and TAS ( P 〈 0.001) were higher in the control group. There was no difference in the levels of neopterin, CRP, TNF‐α and IL‐6. In patients with HG, a positive correlation was detected between TOS and serum levels of lactate dehydrogenase, while TNF‐α, IL‐6 and neopterin were positively correlated with hemoglobin levels. Conclusion Our results demonstrated no association between inflammation and HG. Elucidation of the pathophysiology and complex interaction between various inflammatory processes in HG necessitates further trials on larger series.
Type of Medium:
Online Resource
ISSN:
1341-8076
,
1447-0756
DOI:
10.1111/jog.2016.42.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
1327307-3
detail.hit.zdb_id:
2079101-X
Permalink