In:
Molecules, MDPI AG, Vol. 27, No. 17 ( 2022-09-01), p. 5647-
Abstract:
Herein, we report the application of an efficient and practical K2CO3 promoted cascade reaction of 2-acetylbenzonitrile in the synthesis of novel 3-methylated analogs of Pazinaclone and PD172938, belonging to isoindolinones heterocyclic class bearing a tetrasubstituted stereocenter. Organocatalytic asymmetric synthesis of the key intermediate and its transformation into highly enantioenriched 3-methylated analog of (S)-PD172938 was also developed. These achievements can be of particular interest also for medicinal chemistry, since the methyl group is a very useful structural modification in the rational design of new and more effective bioactive compounds.
Type of Medium:
Online Resource
ISSN:
1420-3049
DOI:
10.3390/molecules27175647
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2008644-1
Permalink