In:
Synthesis, Georg Thieme Verlag KG, Vol. 54, No. 09 ( 2022-05), p. 2081-2102
Abstract:
Over the past years, Pd(II)-catalyzed oxidative couplings have enabled the construction of molecular scaffolds with high structural diversity via C–C, C–N and C–O bond-forming reactions. In contrast to the use of stoichiometric amounts of more common oxidants, such as metal salts (Cu and Ag) and benzoquinone derivatives, the use of molecular oxygen for the direct or indirect regeneration of Pd(II) species presents itself as a more viable alternative in terms of economy and sustainability. In this review, we describe recent advances on the development of Pd-catalyzed oxidative cyclizations/functionalizations, where molecular oxygen plays a pivotal role as the sole stoichiometric oxidant. 1 Introduction 2 Oxidative C–C and C–Nu Coupling 2.1 Intramolecular Oxidative C–Nu Heterocyclization Reactions 2.1.1 C–H Activation 2.1.2 Wacker/Aza-Wacker-Type Cyclization 2.1.3 Tandem Wacker/Aza-Wacker and Cyclization/Cross-Coupling Reactions 2.2 Intermolecular Oxidative C–Nu Heterocoupling Reactions 2.3 Intramolecular Oxidative (C–C) Carbocyclization Reactions 2.4 Intermolecular Oxidative C–C Coupling Reactions 2.4.1 Cyclization Reactions 2.4.2 Cross-Coupling Reactions 2.4.3 Homo-Coupling Reactions 3 Aerobic Dehydrogenative Coupling/Functionalization 4 Oxidative C–H Functionalization 5 Summary
Type of Medium:
Online Resource
ISSN:
0039-7881
,
1437-210X
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
detail.hit.zdb_id:
204080-3
detail.hit.zdb_id:
2033062-5
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