In:
Cancer, Wiley, Vol. 129, No. 5 ( 2023-03), p. 714-727
Abstract:
This study provides early insight of PD‐L1– and cytotoxic T‐cell–centered immune profiles in preinvasive lesions and invasive‐disease transition. The authors report, within the unique context of a prospective study designed with a primary end point of invasive cancer, that the onset of a PD‐L1–mediated immune‐suppressive microenvironment can occur in premalignancy, a positive association between PD‐L1 expression in oral premalignant epithelium, high risk molecular features (i.e., 9p21.3 loss of heterozygosity status and polysomy), and inferior oral cancer‐free survival.
Type of Medium:
Online Resource
ISSN:
0008-543X
,
1097-0142
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1479932-7
detail.hit.zdb_id:
2599218-1
detail.hit.zdb_id:
2594979-2
detail.hit.zdb_id:
1429-1
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