In:
Angewandte Chemie, Wiley, Vol. 130, No. 34 ( 2018-08-20), p. 11201-11205
Abstract:
The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry‐BF 4 ) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C−N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C−O, C−N, C−S, or C−SO 2 R bonds are disclosed herein. In contrast to C−N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional‐group tolerance. In addition to small‐molecule derivatization, Pyry‐BF 4 allows the introduction of functional groups in a late‐stage fashion to furnish highly functionalized structures.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.34
DOI:
10.1002/ange.201806271
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
505868-5
detail.hit.zdb_id:
506609-8
detail.hit.zdb_id:
514305-6
detail.hit.zdb_id:
505872-7
detail.hit.zdb_id:
1479266-7
detail.hit.zdb_id:
505867-3
detail.hit.zdb_id:
506259-7
Permalink