In:
Journal of Surgical Oncology, Wiley, Vol. 105, No. 2 ( 2012-02), p. 175-182
Abstract:
microRNAs (miRNAs), small non‐coding RNAs, are always aberrantly expressed in many diseases including human cancers. The aim of this study was to examine and determine the clinical significance of hsa‐miR‐31, hsa‐miR‐142‐3p, hsa‐miR‐338‐3p, and hsa‐miR‐1261 expression in esophageal squamous cell carcinoma (ESCC). Methods Expression levels of four selected miRNAs, initially evaluated by microarray, were validated by qRT‐PCR. Various statistical methods were used to analyze the relationship between miRNA expression and clinicopathologic features and prognosis in 91 patients with ESCC. Results MiR‐31 and miR‐142‐3p expression were correlated to histological differentiation in ESCC ( P 〈 0.05, Student's t ‐test); high miR‐142‐3p expression was associated with a poor prognosis in all 91 ESCC patients ( P = 0.014, log‐rank) and identified as an independent prognostic factor in ESCC ( P = 0.017, univariate Cox; P = 0.022, multivariate Cox). More importantly, stratified analysis indicated that high miR‐142‐3p expression was correlated to a poor prognosis within good‐prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P 〈 0.05). Conclusion The main findings suggest that miR‐142‐3p is involved in the progression of ESCC and is a potential prognostic biomarker for ESCC. J. Surg. Oncol. 2012; 105:175–182. © 2011 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
82063-5
detail.hit.zdb_id:
1475314-5
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