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  • 1
    Online Resource
    Online Resource
    Biofilm Inhibition: Compounds with Antibacterial Effects
    Walter de Gruyter GmbH ; 2018
    In:  Journal of Interdisciplinary Medicine Vol. 3, No. 4 ( 2018-12-01), p. 234-238
    Details
    In: Journal of Interdisciplinary Medicine, Walter de Gruyter GmbH, Vol. 3, No. 4 ( 2018-12-01), p. 234-238
    Abstract: Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a major potential for this type of persistent bacterial infection. This bibliographic study aims to present the main compounds that act by inhibiting or destroying the bacterial biofilm.
    Type of Medium: Online Resource
    ISSN: 2501-8132
    URL: Article
    DOI: 10.2478/jim-2018-0042
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 2935867-X
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  • 2
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    Online Resource
    Early Outcomes in Anterior Cruciate Ligament Reconstruction: Full Tibial tunnel technique compared to all-inside technique
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 69, No. 12 ( 2019-1-15), p. 3753-3755
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 69, No. 12 ( 2019-1-15), p. 3753-3755
    Abstract: The all-inside technique for ACL reconstruction uses the semitendinous muscle tendon as a graft, and postoperative pain is slightly reduced. Through the full tibial tunnel technique, better anatomical graft placement is obtained with promising results, yet there are only few scientific articles comparing the two techniques. The main objective is evaluation of results after ACL reconstruction by comparing the clinical results of the two surgical techniques. A prospective study was conducted that included 63 eligible patients according to pre-established criteria. The technique used was randomly indicated to each patient. Demographics and clinical examination results were collected and subsequently stored. The assessment tools used were the International Knee Documentation Committee (IKDC), Knee injury and Osteoarthritis Outcome Score (KOOS) and the Visual Analogue Scale (VAS) with a 6-month follow-up period. The statistical analysis was performed for preoperative follow-up scores, at 3 and 6 months. All patients were operated by the same surgical team under spinal anesthesia with nerve block and tourniquet applied.In regards to IKDC and KOOS scores, the difference between the two interventions was not statistically significant (p = .579 and p = .710). Postoperative pain was slightly reduced in patients in the all-inside\ group but without any statistical significance compared to full-tibial tunnel technique(p = .259). There were no graft ruptures or late postoperative complications. Regarding IKDC, KOOS and VAS evaluating tools, there is no statistically significant difference between the two evaluated methods for ACL reconstruction, all-inside and full tibial tunnel at 3 months and 6 months after surgery.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.18.12.6835
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 3
    Online Resource
    Online Resource
    Computer-Aided Diagnosis in Colorectal Cancer: Current Concepts and Future Prospects
    Walter de Gruyter GmbH ; 2017
    In:  Journal of Interdisciplinary Medicine Vol. 2, No. 3 ( 2017-9-1), p. 245-249
    Details
    In: Journal of Interdisciplinary Medicine, Walter de Gruyter GmbH, Vol. 2, No. 3 ( 2017-9-1), p. 245-249
    Abstract: Colorectal cancer is an important health issue, both in terms of the number of people affected and the associated costs. Colonoscopy is an important screening method that has a positive impact on the survival of patients with colorectal cancer. The association of colonoscopy with computer-aided diagnostic tools is currently under researchers’ focus, as various methods have already been proposed and show great potential for a better management of this disease. We performed a review of the literature and present a series of aspects, such as the basics of machine learning algorithms, different computational models as well as their benchmarks expressed through measurements such as positive prediction value and accuracy of detection, and the classification of colorectal polyps. Introducing computer-aided diagnostic tools can help clinicians obtain results with a high degree of confidence when performing colonoscopies. The growing field of machine learning in medicine will have a big impact on patient management in the future.
    Type of Medium: Online Resource
    ISSN: 2501-8132
    URL: Article
    DOI: 10.1515/jim-2017-0057
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2935867-X
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  • 4
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    Online Resource
    From Basic Science to Clinical Perfection: What Defines the Orthopedic Biocompatible Implant?
    MDPI AG ; 2022
    In:  Surgeries Vol. 4, No. 1 ( 2022-12-27), p. 1-9
    Details
    In: Surgeries, MDPI AG, Vol. 4, No. 1 ( 2022-12-27), p. 1-9
    Abstract: The general improvement in life expectancy and standard of living makes it easier for patients to get access to routine medical exams and is anticipated to increase the prevalence of several degenerative joint illnesses. In addition, it is anticipated that their incidence will increase both nationally and internationally, which will raise the demand for novel and long-lasting implantable devices in the field of orthopedics. The current review’s goals are to define what constitutes a biocompatible orthopedic implant in terms of in vitro biocompatibility testing and to clarify important concepts and definitions that are already in use. The demand for materials and implants made of various tissues is now increasing, and the ongoing advancement of in vitro cell culture studies is a reliable practical tool for examining the biocompatibility of potential implantable materials. In vitro biocompatibility research has been reduced and, in most cases, diminished to laboratory studies that no longer or drastically reduce animal sacrifice as a response to the well-known three “Rs” (“reduction”, “refinement”, and “replacement”) introduced to literature by English academics in the 1960s. As technology advances at an astounding rate, a new generation of gene-activating biomaterials tailored for specific people and disease conditions might emerge in the near future.
    Type of Medium: Online Resource
    ISSN: 2673-4095
    URL: Article
    DOI: 10.3390/surgeries4010001
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 3021986-3
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  • 5
    Online Resource
    Online Resource
    The Presence of a ‘Sentinel’ Vessel as an Anatomical Reference during Hamstring Tendon Harvesting—A Prospective Study
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 16 ( 2023-08-21), p. 5426-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 16 ( 2023-08-21), p. 5426-
    Abstract: Background: The identification of the branch of the inferior medial genicular artery (bIMGA) in anterior cruciate ligament reconstructions (ACLRs) has previously been considered a landmark by some surgeons, but its consistency remains debated. The aim of this investigation was to evaluate the variability in the appearance and location of bIMGA and to assess its validity as a reliable landmark during hamstring tendon harvesting procedures. Methods: This prospective, single-center study comprised 213 patients who underwent ACLR over a period of two years. The surgical procedures were conducted by the same surgical team, maintaining uniformity in the approach. The study sought correlations between patient demographics, level of activity, and the potential for successful identification of the bIMGA. Results: A statistically significant association between patient activity levels and successful identification of the bIMGA (p = 0.035) was observed. No significant correlations were found concerning patient demographic characteristics. bIMGA demonstrated a substantial degree of anatomical variability, rendering its consistent identification in the surgical field challenging. Conclusions: Given the observed variability and the associated difficulty in its identification, the use of the bIMGA as a dependable anatomical reference during ACL graft harvesting is not recommended. This study confirms the inconsistency of bIMGA as a traditional landmark, underscoring the need for research aimed at identifying more consistent and reliable anatomical references to enhance the precision of surgical interventions in ACLR.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12165426
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 6
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    Online Resource
    Biocompatible 3D-Printed Devices With Adipose Stem Cells in the Regenerative Process of Sciatic Nerve Lesions in Rodent Models: An Experimental Study
    Springer Science and Business Media LLC ; 2024
    In:  Cureus
    Details
    In: Cureus, Springer Science and Business Media LLC
    Type of Medium: Online Resource
    ISSN: 2168-8184
    URL: Article
    DOI: 10.7759/cureus.62412
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2747273-5
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  • 7
    Online Resource
    Online Resource
    Reduced Analgesics Consumption and Pain Intensity after Injections with a New Hyaluronic Acid in Patients with Knee Osteoarthritis
    Walter de Gruyter GmbH ; 2017
    In:  Acta Medica Marisiensis Vol. 63, No. 3 ( 2017-9-1), p. 121-124
    Details
    In: Acta Medica Marisiensis, Walter de Gruyter GmbH, Vol. 63, No. 3 ( 2017-9-1), p. 121-124
    Abstract: Objective : To determine the influence of a new intraarticular hyaluronic acid based hydrogel (Hymovis®) injections on the amount of analgesics consumption in patients diagnosed with primary knee OA. Methods : A prospective, single-center study that included 35 patients, aged 45-80 years was conducted in our orthopaedics department. Patients received two intra-articular injections of hyaluronic acid (24 mg/3 ml; 500–730 kDa; Hymovis®) at one week apart. Follow-up was scheduled at 2 and 6 months after the injections. Assessment tools included Visual Analogue Scale (VAS) and an in-house designed questionnaire regarding analgesic consumption (quantity, period and product) during the follow-up. Results : Compared to baseline, a significant amelioration in visual analogue scale was observed at six months’ follow-up (74.2mm ± 11.7 vs. 57.3mm ± 12.1; p 〈 .0001). 28% (n=10) of the patients reduced their total analgesic consumption at two months after the injections. At final follow-up, the analgesic intake was reduced by more than 50% in almost every case. Conclusions : Intraarticular administered injections with a novel hyaluronan-based hydrogel (Hymovis®) may reduce the amount of analgesic consumption and self-reported pain intensity in patients with knee OA.
    Type of Medium: Online Resource
    ISSN: 2247-6113
    URL: Article
    DOI: 10.1515/amma-2017-0016
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2625583-2
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  • 8
    Online Resource
    Online Resource
    Anatomic All-Inside Anterior Cruciate Ligament Reconstruction Using the TransLateral Technique
    Walter de Gruyter GmbH ; 2017
    In:  Journal of Interdisciplinary Medicine Vol. 2, No. s3 ( 2017-5-1), p. 17-21
    Details
    In: Journal of Interdisciplinary Medicine, Walter de Gruyter GmbH, Vol. 2, No. s3 ( 2017-5-1), p. 17-21
    Abstract: Background: Anterior cruciate ligament (ACL) reconstruction is a commonly performed procedure and considered to be the gold standard in restoring knee function and stability in ACL-deficient knees. The TransLateral all-inside technique implies the use of only two portals – anterolateral and anteromedial, without the use of an accessory portal. The work is done using the lateral portal, while the medial portal serves as a viewing site. Only a few studies have been published regarding the assessment of the functional and clinical outcomes of this novel technique. Aim of the study: To determine the clinical effectiveness of the TransLateral procedure used for ACL reconstruction and its ability to re-establish joint functionality and stability in ACL-deficient knees. Material and methods: A prospective study was conducted at the Orthopedics and Traumatology Clinic no. 2 in Tîrgu Mureș. Thirty-two patients matched our inclusion criteria and were operated using the TransLateral technique for ACL reconstruction. Outcome assessment was performed using the Knee injury and Osteoarthritis Outcome Score (KOOS), the Lysholm score and the Tegner Activity Scale. The questionnaires include items referring to pain, physical functioning, sports activities, and quality of life. Operative time and ACL graft size were also documented. Results: All patients underwent single-bundle ACL restoration using a quadrupled semitendinosus tendon. Out of 32 patients, 21 had associated meniscus lesions and 8 collateral ligament injuries. Mean graft diameter was 8.7 mm and mean length 63.2 mm. Significantly improved KOOS values were found at 12 months post-surgery regarding the mean baseline score: 59.3 ± 5.3 vs. 95.3 ± 4.9, p 〈 0.0001. The Lysholm score improved from a mean of 56.3 ± 4.9 to 93.9 ± 5.6, p 〈 0.0001 at the end-point. The Tegner activity scale ranged from 3.8 ± 1.9 to 5.9 ± 2.4, p 〈 0.0001 at the final follow-up. Conclusions: The TransLateral technique proved its clinical effectiveness and its ability to restore knee stability after ACL reconstruction surgery.
    Type of Medium: Online Resource
    ISSN: 2501-8132
    URL: Article
    DOI: 10.1515/jim-2017-0039
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2017
    detail.hit.zdb_id: 2935867-X
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  • 9
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    Online Resource
    Clinical and morphological outcomes after percutaneous needle fasciotomy in Dupuytren’s disease according to the contracture severity
    Societatea Romana de Morfologie ; 2021
    In:  Romanian Journal of Morphology and Embryology Vol. 62, No. 3 ( 2021-03-17), p. 777-784
    Details
    In: Romanian Journal of Morphology and Embryology, Societatea Romana de Morfologie, Vol. 62, No. 3 ( 2021-03-17), p. 777-784
    Type of Medium: Online Resource
    ISSN: 1220-0522 , 2066-8279
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.47162/RJME.62.3
    DOI: 10.47162/RJME
    DOI: 10.47162/RJME.62.3.15
    Language: Unknown
    Publisher: Societatea Romana de Morfologie
    Publication Date: 2021
    detail.hit.zdb_id: 2594131-8
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  • 10
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    Transfemoral Approach in Revision Hip Arthroplasty: A Prospective Analysis of 36 Cases: Radiological and Functional Results at a Minimum 2 Years Follow-up
    MDPI AG ; 2022
    In:  Medicina Vol. 58, No. 2 ( 2022-02-04), p. 237-
    Details
    In: Medicina, MDPI AG, Vol. 58, No. 2 ( 2022-02-04), p. 237-
    Abstract: Background and Objectives: One of the most difficult aspects of hip revision is to remove the stem from the femoral canal with or without cement while maintaining the maximal amount of bone stock to obtain the best possible press-fit of the revision prosthesis. The transfemoral approach ensures direct access to the medullary canal so that the content removal is completed under direct control, while protecting the bone. This type of approach is particularly efficient for special conditions, such as deformation of the proximal femoral region, broken stems, or the presence of cement over a long distance distal to the prosthesis. The aim of this study was to evaluate the main advantages of transtrochanteric approach in hip revisions. Materials and Methods: Our series included 36 revisions performed using the transfemoral approach. We have analyzed the following postoperative radiological aspects: the length of the fixation zone distal to the osteotomized bone fragment (OBF), the gap between the OBF and the diaphysis, stem subsidence over time, and OBF consolidation. Results: The results were very good, both in terms of the rate of intraoperative complications and postoperative evolution. The fixation zone length was 4.2 cm on average (range: 2 to 5.8 cm). The distal gap between the OBF and the diaphysis was 1.2 cm on average (range: 0 to 2.3 cm). Stem subsidence was noted in four cases (11.1%). In all cases, stem subsidence occurred between three and six months and was 6 to 8 mm without affecting hip stability. OBF consolidation was radiologically confirmed for all cases at one year follow-up. Clinical assessment based on the Harris Hip Score showed an overall improvement from 43.2 preoperatively to 79.7 at 12 months and 83 at two years, respectively. The most important rate of progress was between 6 months and 12 months. Conclusions: The transtrochanteric approach has been shown to be very efficient for hip revisions. Understanding the hip biomechanics, applying a less aggressive surgical technique, and using efficient fixation methods such as cables significantly improved the results.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina58020237
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2088820-X
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