In:
Nephrology Dialysis Transplantation, Oxford University Press (OUP), Vol. 38, No. Supplement_1 ( 2023-06-14)
Abstract:
Post-transplant diabetes mellitus (PTDM) might impact significantly in renal transplant (RTx) and RTx patients (RTxps) outcome. In this study we evaluated: 1) the prevalence of diabetic patients who access the RTx 2) the incidence of PTDM and 3) the most related factors for the development of diabetes after RTx. Method We retrospectively studied 522 RTxps transplanted in our Unit between January 2004 and December 2014. Each patient underwent: 1) to a collection of remote and pathological anamnesis and complete physical examination and to routine and specific clinical and biochemical determinations at 1(T1), 6 (T6) and 12 (T12) months after RTx. At six months of RTx, the Oral Glucose Tolerance Test (OGTT) was performed. Results The age of RTxps was 48±12 years. Patients with glucose metabolism abnormalities were significantly older, without differences in gender. Inpatients with PTDM (12.6%), cyclosporine was used more than tacrolimus, and higher doses of steroids at T1 and T6 were prescribed. They had a worse general metabolic and glucose (HOMA index, glycaemia and HbA1c) status than normoglycemic. of note, no differences in 25-(OH)-D and in the other mineral metabolism parameters were found. In multivariate analysis, we found that age at transplant (OR 1.28 for 5 years older) (p = 0.006), BMI at T1 (OR 1.22 for 2 kg / m2 more) (p = 0.01) and the dose of steroid prescribed during the first post-RTx month (OR 2.7 per 100 mg additional drug) (p = 0.03) were independently correlated with PTDM. Conclusion In this study, we demonstrated that the prevalence of PTDM was relatively high in our cohort reflecting data present in the literature. Interestingly, age at RTx, BMI and cumulative dose of steroids resulted the variables that significantly and strongly influence its development. On the other hand, no relationship was observed between blood values of 25 (OH) D, PTH and the onset of PTDM. Future research, possibly involving a higher number ofRTxps could also evaluate the effects of PTDM on graft and patients on long-term outcome.
Type of Medium:
Online Resource
ISSN:
0931-0509
,
1460-2385
DOI:
10.1093/ndt/gfad063d_4676
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2023
detail.hit.zdb_id:
1465709-0
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