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  • 1
    Online Resource
    Online Resource
    Adult human neurogenesis: A view from two schools of thought
    Elsevier BV ; 2023
    In:  IBRO Neuroscience Reports ( 2023-7)
    Details
    In: IBRO Neuroscience Reports, Elsevier BV, ( 2023-7)
    Type of Medium: Online Resource
    ISSN: 2667-2421
    URL: Article
    DOI: 10.1016/j.ibneur.2023.07.004
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 3061524-0
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  • 2
    Online Resource
    Online Resource
    Neuromarketing: The Physiological Tools for Understanding Consumer Behaviour
    Secholian Publication ; 2023
    In:  Malaysian Journal of Social Sciences and Humanities (MJSSH) Vol. 8, No. 1 ( 2023-01-31), p. e002081-
    Details
    In: Malaysian Journal of Social Sciences and Humanities (MJSSH), Secholian Publication, Vol. 8, No. 1 ( 2023-01-31), p. e002081-
    Abstract: Traditional techniques can measure cognitive and emotional verbal expressions below the consciousness level. The disadvantages of this technique is not able to provide information on emotional responses in an unconscious state. Artificial intelligence of neural network is a cost-effective and an alternative for neuromarketing tools. Neuromarketing is a new technique for designing marketing strategies, especially advertising campaigns. The tools in neuroscience to measure behavioural response based on psychology, such as behaviour prediction and cognitive patterns. Marketers have used a variety of different tools, such as functional magnetic resonance imaging (fMRI), eye tracking, electroencephalography (EEG), facial expressions, galvanic skin response (GSR) and others. Therefore, neuromarketing holds great potential for marketers to manufacturing sectors in the coming year.
    Type of Medium: Online Resource
    ISSN: 2504-8562
    URL: Article
    DOI: 10.47405/mjssh.v8i1.2081
    Language: Unknown
    Publisher: Secholian Publication
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    THE RELATION OF STROKE PATIENT’S CORTISOL LEVEL TO NATIONAL INSTITUTES OF HEALTH STROKE SCALE CORE ON SPONTANEOUS INTRACEREBRAL HEMORRHAGE: AN OBSERVASIONAL STUDY AT RUMAH SAKIT UMUM DAERAH (REGIONAL PUBLIC HOSPITAL) DR. SOETOMO IN SURABAYA
    Innovare Academic Sciences Pvt Ltd ; 2019
    In:  Asian Journal of Pharmaceutical and Clinical Research Vol. 12, No. 1 ( 2019-01-07), p. 469-
    Details
    In: Asian Journal of Pharmaceutical and Clinical Research, Innovare Academic Sciences Pvt Ltd, Vol. 12, No. 1 ( 2019-01-07), p. 469-
    Abstract: Objective: The objective of the study was to find out differences in the cortisol level characteristics and National Institutes of Health Stroke Scale (NIHSS) score in the 1st and 7th days on patients treated at Dr. Soetomo Regional Hospital; thus, it can be the right education for stroke patients.Methods: A prospective observational study was carried out against stroke patients treated in the neurosurgery department on September 2016– March 2017. Evaluation was done to all patients treated at the neurosurgery department. The evaluation process began with basal hormones within the first 24 h and taken at 6:00 and repeated on the 7th day to surviving patients. Of all the data obtained, the category scale data are presented by its frequency distribution, while numerical scale data are presented by its descriptive value (average and standard deviation).Results: Of the 17 patients surviving until the 7th day, there is a decrease at the average cortisol level on the 1st day when compared to the average cortisol level on the 7th day with a mean value of 39.67–36.57 and so is the highest cortisol level; it decreases from the 1st day of 61.45 to the 7th day of 56.70. Meanwhile, in the NIHSS score value, the decrease in score only occurs in the average value on the 1st and 7th days from an average of 22.82 into 21.41, whereas minimum and maximum scores do not change. With the test result, the cortisol level characteristic gets a score of p 〈 0.05; thus, there is a significant difference.Conclusion: Of the result of observation already carried out on stroke patients treated at Dr. Soetomo Regional Hospital, treatment and education levels for patients who have a risk of stroke factor are very important.
    Type of Medium: Online Resource
    ISSN: 2455-3891 , 0974-2441
    URL: Article
    DOI: 10.22159/ajpcr.2019.v12i1.28405
    Language: Unknown
    Publisher: Innovare Academic Sciences Pvt Ltd
    Publication Date: 2019
    detail.hit.zdb_id: 2500247-8
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  • 4
    Online Resource
    Online Resource
    Periosteum-induced ossification effect in skull defect through interleukin-8 and NF-κB pathway: An experimental study with Oryctolagus cuniculus rabbits
    Scientific Scholar ; 2022
    In:  Surgical Neurology International Vol. 13 ( 2022-04-15), p. 140-
    Details
    In: Surgical Neurology International, Scientific Scholar, Vol. 13 ( 2022-04-15), p. 140-
    Abstract: The purpose of this study was to analyze the response of inflammatory cytokines interleukin-8 (IL-8) and NF-κB to the closure of skull defect with periosteum as a scaffolding material in bone healing used after surgery. Methods: Thirty Oryctolagus cuniculus rabbits underwent a craniotomy to create a 20 mm diameter round defect in the parietal bones. The parietal bones were returned to its place and stabilized by an internal plate fixation. The defects were either left empty or implanted with periosteum. At 6 weeks, the specimens were euthanized and examined. Results: Histological examination showed a more well-developed formation of woven bone in the periosteum group. Immunohistochemical examinations showed that the use of periosteum in the closure of skull defects reduced the NF-κB and IL-8 response which affected the ossification process. Conclusion: The experiment showed that the use of periosteum was linked with IL-8 and NF-κB downregulation toward ossification effects at any point throughout the trial. Periosteum usage might be beneficial as a scaffolding material in bone healing for autograft cranioplasty in animal model and could be applied to clinical practice.
    Type of Medium: Online Resource
    ISSN: 2152-7806
    URL: Article
    DOI: 10.25259/SNI_62_2022
    Language: English
    Publisher: Scientific Scholar
    Publication Date: 2022
    detail.hit.zdb_id: 2567759-7
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  • 5
    Online Resource
    Online Resource
    Case of malignant brain edema despite successful recanalization after mechanical thrombectomy for anterior circulation stroke
    Scientific Scholar ; 2023
    In:  Surgical Neurology International Vol. 14 ( 2023-03-31), p. 111-
    Details
    In: Surgical Neurology International, Scientific Scholar, Vol. 14 ( 2023-03-31), p. 111-
    Abstract: Therapeutic reperfusion with endovascular treatment (EVT) for acute ischemic stroke is typically associated with better long-term functional outcome compared to standard medical care. However, post-procedural brain edema remained present in around half of EVT patients. Malignant brain edema (MBE) is a serious condition that can lead to increased intracranial pressure, rapid neurologic deterioration, and cerebral herniation, neutralizing the favorable efficacy of EVT on functional outcomes. Case Description: A 51-year-old man with a history of atrial fibrillation presented with acute onset of hemiplegia and severe bradyarrhythmia. A head computed tomography-scan demonstrated hyperdense middle cerebral artery (MCA) sign. Intravenous thrombolysis was administered before temporary pacemaker insertion. The digital subtraction angiography confirmed occlusion of the M1 branch of the right MCA with no collaterals in the territory of the occluded vessel. Mechanical thrombectomy (MT) was performed 6 h after onset and successfully achieved modified thrombolysis in cerebral infarction 3 revascularization in 6 h 20 min. The patient later experienced massive brain edema that required emergent decompressive craniectomy. The modified Rankin scale score was 4 in 1- and 3-month’s follow-up. Conclusion: MBE after MT results in unsatisfactory functional outcomes, even if it has successful revascularization. No collateral in the territory of the occluded vessel in the initial angiogram is one of the predictors of MBE after MT.
    Type of Medium: Online Resource
    ISSN: 2152-7806 , 2229-5097
    URL: Article
    DOI: 10.25259/SNI_28_2023
    Language: English
    Publisher: Scientific Scholar
    Publication Date: 2023
    detail.hit.zdb_id: 2567759-7
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  • 6
    Online Resource
    Online Resource
    Comparison of the Administration Route of Stem Cell Therapy for Ischemic Stroke: A Systematic Review and Meta-Analysis of the Clinical Outcomes and Safety
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 7 ( 2023-04-06), p. 2735-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 7 ( 2023-04-06), p. 2735-
    Abstract: Stem cell treatment is emerging as an appealing alternative for stroke patients, but there still needs to be an agreement on the protocols in place, including the route of administration. This systematic review aimed to assess the efficacy and safety of the administration routes of stem cell treatment for ischemic stroke. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A comprehensive literature search was undertaken using the PubMed, Scopus, and Cochrane databases. A total of 21 publications on stem cell therapy for ischemic stroke were included. Efficacy outcomes were measured using the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the Barthel index (BI). Intracerebral administration showed a better outcome than other routes, but a greater number of adverse events followed due to its invasiveness. Adverse events were shown to be related to the natural history of stroke not to the treatment. However, further investigation is required, since studies have yet to compare the different administration methods directly.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12072735
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 7
    Online Resource
    Online Resource
    Current update on stroke ischemic management : Stem cell as emerging therapy
    Scientific and Literature Open Access Publishing ; 2022
    In:  International journal of health & medical sciences Vol. 5, No. 1 ( 2022-02-05), p. 122-128
    Details
    In: International journal of health & medical sciences, Scientific and Literature Open Access Publishing, Vol. 5, No. 1 ( 2022-02-05), p. 122-128
    Abstract: Stroke is one of the most important causes of morbidity and mortality worldwide, with survivors subjected to long-term disability. Stroke is classified as ischemic and hemorrhagic. 87 % of strokes are classified as ischemic. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by an ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons to improve neurological recovery. Further understanding of the mechanisms by which the stem cells exert their beneficial effect could potentially revolutionize the field. The next decade of stem cell research in stroke needs to focus on. Although still in need of exploration, stem cell treatments for stroke may offer ways to protect and replace neurons to improve outcomes for stroke patients.
    Type of Medium: Online Resource
    ISSN: 2632-9433
    URL: Issue
    URL: Article
    DOI: 10.21744/ijhms.v5n1.2022
    DOI: 10.21744/ijhms.v5n1.1851
    Language: Unknown
    Publisher: Scientific and Literature Open Access Publishing
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    Neuroangiography patterns of the middle cerebral artery: Study of 554 cerebral angiography results
    Elsevier BV ; 2019
    In:  Journal of Clinical Neuroscience Vol. 68 ( 2019-10), p. 62-68
    Details
    In: Journal of Clinical Neuroscience, Elsevier BV, Vol. 68 ( 2019-10), p. 62-68
    Type of Medium: Online Resource
    ISSN: 0967-5868
    URL: Article
    DOI: 10.1016/j.jocn.2019.07.054
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2009190-4
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  • 9
    Online Resource
    Online Resource
    Expression of Growth Associated Protein-43 (GAP-43) and Brain-derived Neurotrophic Factor (BDNF) from Adipose Mesenchymal Stem Cells (ASC) with fresh frozen nerve scaffold in 5% hypoxic condition
    DiscoverSys, Inc. ; 2021
    In:  Bali Medical Journal Vol. 10, No. 3 ( 2021-10-23), p. 887-894
    Details
    In: Bali Medical Journal, DiscoverSys, Inc., Vol. 10, No. 3 ( 2021-10-23), p. 887-894
    Abstract: Background: Peripheral nerve injury is one of the most common musculoskeletal injuries, and the healing is prolonged and affects the patient's quality of life. Secretomes derived from Adipose Stem Cells (ASC) is widely researched in tissue engineering. Various studies currently focus on observing potential scaffolds in nerve regeneration. This study aims to analyze the expression of Growth Associated Protein-43 (GAP-43) and Brain-derived Neurotrophic Factor (BDNF) produced by ASC culture with fresh frozen nerve scaffold under 5% hypoxic conditions in vitro.Methods: An in vitro experimental laboratory research using the randomized control group post-test only design was conducted at the Dr. Soetomo Hospital Tissue Bank, Surabaya, East Java, Indonesia. Isolated mesenchymal stem cells from fat tissue were characterized using CD-105. If more than 90% of the MSCs membrane surface binds to the CD-105 marker is indicated positive. Hypoxic conditions were applied to culture stem cells with oxygen levels of 5% and several days of cultivation time until they reached passage four and passage eight. ELISA-test for GAP-43 and BDNF was carried out using secretomes obtained from ASC culture with fresh frozen nerve scaffold in normoxic (21%) and hypoxic (5%) conditions. The analysis was performed on the 2nd to 4th day and 6th day of culture using IBM® SPSS® program version 23 for Windows.Results: In this study, there was a significant difference in BDNF expression in the group given fresh frozen nerve scaffold (p=0.040) but no significant difference in the expression of GAP-43 in the group given fresh frozen nerve scaffold (p=0.214) in normoxic conditions.Conclusion: The 5% hypoxic medium did not provide a significant difference in the expression of GAP-43 and BDNF.
    Type of Medium: Online Resource
    ISSN: 2302-2914 , 2089-1180
    URL: Article
    DOI: 10.15562/bmj.v10i3.2575
    Language: Unknown
    Publisher: DiscoverSys, Inc.
    Publication Date: 2021
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  • 10
    Online Resource
    Online Resource
    Clinical and Radiological Study of Patients With Skull Base Fracture After Head Injury
    Universitas Airlangga ; 2021
    In:  Folia Medica Indonesiana Vol. 57, No. 3 ( 2021-09-05), p. 192-
    Details
    In: Folia Medica Indonesiana, Universitas Airlangga, Vol. 57, No. 3 ( 2021-09-05), p. 192-
    Abstract: Traumatic brain injury (TBI) is the largest contributor to morbidity and mortality in various parts of the world. Skull base fracture (SBF) is one of the many manifestations that can occur in cases of mild to severe TBI. With varying patterns of TBI, it was necessary to review the characteristics of SBF, clinical manifestations, cerebrospinal fluid leakage, and complications. The data were taken from the medical records of SBF patients who were treated at RSUD (Regional Public Hospital) Dr. Soetomo in the period January 2014 - July 2019. Then, the data obtained were written on the collection sheet and analyzed descriptively using RKward. It was found that SBF most often occurs due to severe TBI (60.14%). 77.7% of SBF patients were male and 35.1% of all patients aged 15-24 years. The most frequent cause was traffic accidents (86.5%). The anterior cranial fossa (ACF) was the most frequently fractured part of the skull base (30.4%). There was a significant relationship between the severity of TBI with the occurrence of CSF leakage and complications. About 33 patients (22.3%) had complications such as pneumocephalus and 9 patients (6.1%) had meningitis. Complications in the form of brain abscess and hydrocephalus in 1 (0.7%) patient each. SBF often occurred in men of productive age 15-24 years. The ACF was the most frequently fractured part. The majority were caused by traffic accidents accompanied by severe brain injuries. The most common complications were pneumocephalus, meningitis, brain abscess, and hydrocephalus.
    Type of Medium: Online Resource
    ISSN: 2599-056X , 2355-8393
    URL: Article
    DOI: 10.20473/fmi.v57i3.22824
    Language: Unknown
    Publisher: Universitas Airlangga
    Publication Date: 2021
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