In:
Rapid Communications in Mass Spectrometry, Wiley, Vol. 21, No. 22 ( 2007-11-30), p. 3561-3568
Abstract:
Single over‐the‐counter medication tablets were analyzed in real time using Single Particle Aerosol Mass Spectrometry (SPAMS). Dual‐polarity time‐of‐flight mass spectra were obtained for micrometer‐sized single particles dislodged from a single tablet without destroying the shape or markings of each tablet. The solid tablet was placed in a modified‐top glass vial and shaken to dislodge and introduce micrometer‐sized particles into the SPAMS system. Unique spectra from these particles were obtained in less than 1 s for single tablets of aspirin, ibuprofen, pseudoephedrine, phenylephrine, loratadine, or diphenhydramine. The signals obtained allowed the non‐destructive identification of an individual tablet in seconds. SPAMS presents an ideal system for high‐throughput analysis of solid drugs. Copyright © 2007 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0951-4198
,
1097-0231
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2002158-6
detail.hit.zdb_id:
58731-X
SSG:
11
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