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  • 1
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    Effect of post-isometric relaxation versus myofascial release therapy on pain, functional disability, rom and qol in the management of non-specific neck pain: a randomized controlled trial
    Springer Science and Business Media LLC ; 2022
    In:  BMC Musculoskeletal Disorders Vol. 23, No. 1 ( 2022-12)
    Details
    In: BMC Musculoskeletal Disorders, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12)
    Kurzfassung: Non-specific neck pain is the most prevailing musculoskeletal disorder which has a large socioeconomic burden worldwide. It is associated with poor posture and neck strain which may lead to pain and restricted mobility. Physical therapists treat such patients through several means. Post isometric relaxation and Myofascial release therapy are used in clinical practice with little evidence to be firmed appropriately. So, this study was conducted to explore the effect of Post-isometric relaxation in comparison to Myofascial release therapy for patients having non-specific neck pain. Methodology Sixty patients were randomly allocated to Post isometric group and the Myofascial group. The treatment period was of 2 weeks. All the patients were evaluated using the Visual analogue scale (VAS), Neck disability index (NDI), Universal Goniometer, and WHO BREF Quality of life-100 in the 1st and 6th sessions. Recorded data was entered on SPSS 21. Data were examined using two-way repeated ANOVA to measure the variance of analysis (group x time). Results Analysis of the baseline characteristics revealed that both groups were homogenous in terms of age and gender i.e. a total of 60 participants were included in this research study 30 in each group. Out of 60 patients, there were 20(33.3%) males and 40(66.7%) females with a mean age of 32.4(5.0) years. Participants in the Post Isometric group demonstrated significant improvements ( p   〈  0.025) in VAS, NDI, Cervical Extension, left side rotation ranges, and QoL (Social Domain) at the 2-week follow-up compared with those in the Myofascial group. In addition, the Myofascial group indicated significantly better improvement in the mean score of CROM (flexion and right and left side bending). Conclusion The study demonstrated patients with nonspecific neck pain can benefit from the post isometric relaxation with significant improvement in pain, disability, cervical ROM, and Quality of life compared with myofascial release therapy. Trial registration Clinical Trial registered on clinicaltrial.gov (NCT number) NCT04638062 , 20/11/2020 (prospectively registered).
    Materialart: Online-Ressource
    ISSN: 1471-2474
    URL: Article
    DOI: 10.1186/s12891-022-05516-1
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2041355-5
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  • 2
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    Association of salivary Cathepsin B in different histological grades among patients presenting with oral squamous cell carcinoma
    Springer Science and Business Media LLC ; 2022
    In:  BMC Oral Health Vol. 22, No. 1 ( 2022-03-08)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-03-08)
    Kurzfassung: Oral cancer is considered a major public health problem due to its high mortality and morbidity rates. Survival rate of OSCC can be significantly improved by using non-invasive tool such as salivary biomarkers for detection of OSCC which is considered a promising approach. Cathepsin B is a lysosomal cysteine protease, present in abundant quantities in lysosome of cells, tissues and different biological fluids. Increased expression of Cathepsin B was observed in many malignancies including oral cancer. The present study was designed to determine the salivary levels of Cathepsin B in different histological grades of OSCC. Method In this study, total no. of 80 research participants were enrolled which were divided into four groups. Each group comprised 20 participants, group 1 comprised 20 patients of OSCC (well differentiated), group 2 comprised 20 patients of OSCC (moderately differentiated), group 3 comprised 20 patients of OSCC (poorly differentiated) and group 4 comprised 20 healthy controls. Saliva sample was collected from all the four study groups and salivary Cathepsin B levels were analyzed by ELISA sandwich technique in duplicate. Results Salivary levels of Cathepsin B were significantly increased with p value ( 〈  0.001) in patients of OSCC as compared to control group according to both histological grades and tumor size. Highest mean Cathepsin B levels in well differentiated OSCC followed by poorly differentiated OSCC and moderately differentiated OSCC were observed. Conclusion Results of the present study suggests that Cathepsin B has a great value as a salivary biomarker for diagnosis and monitoring of OSCC in different histological grades. This will further lead to increase survival rate and improve the prognosis of OSCC.
    Materialart: Online-Ressource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-022-02052-1
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2091511-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Estimation of salivary matrix metalloproteinases- 12 (MMP- 12) levels among patients presenting with oral submucous fibrosis and oral squamous cell carcinoma
    Springer Science and Business Media LLC ; 2021
    In:  BMC Oral Health Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Kurzfassung: Oral squamous cell carcinoma is a global threat and accounts for approximately 90% of malignant oral lesions. The emergence of oral carcinoma is linked to precancerous lesions, which act as precursors of the disease. Matrix metalloproteinases appear to play a significant role in the pathogenesis of both precancerous conditions and oral malignancies due to their participation in remodeling of the extracellular matrix. Methodology This is an analytical study conducted at Dow University of Health Sciences, Pakistan. Unstimulated saliva samples were collected from healthy, oral submucous fibrosis and oral squamous cell carcinoma patients. The level of MMP-12 was estimated using enzyme-linked immunosorbent assay. One-way Analysis of variance was run to determine if MMP-12 levels differ between the three groups, which was preceded by post hoc Tuckey test. MMP-12 cut off values were determined using Receiver operating characteristic curve. Results A significant difference in salivary MMP-12 expression was observed in OSF and OSCC ( p   〈  0.001). The expression of salivary MMP-12 was higher in OSF and OSCC patients as compared to the healthy group ( p   〈  0.001). The mean MMP-12 expression in OSCC appeared higher than in OSF cases ( p   〈  0.05). MMP-12 value of $$\ge$$ ≥ 4.05 ng/ml and $$\ge$$ ≥ 4.20 ng/ml is predictive of OSF and OSCC respectively, with 100% sensitivity and specificity ( p   〈  0.001). Conclusion Increased expression of MMP-12 appears as the healthy patient advances to OSF and OSCC. The study results also demonstrate higher MMP-12 expression in OSCC patients as compared to OSF. Therefore, the estimation of salivary MMP-12 serves as a valuable non-invasive early diagnostic tool in diagnosing oral submucous fibrosis and oral squamous cell carcinoma.
    Materialart: Online-Ressource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-021-01571-7
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 2091511-1
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  • 4
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    Analysing root roughness and smear layer relationship by comparing contemporary dental curettes with conventional dental curettes: a randomised controlled trial
    Springer Science and Business Media LLC ; 2022
    In:  BMC Oral Health Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Kurzfassung: Root debridement procedures for the treatment of periodontal diseases, produces root surface irregularities and smear layer on the root surface that can adversely affect the healing of periodontal tissues. The objective of the present study was to evaluate the surface texture of root after hand instrumentation with Gracey curette, After Five curette, and Mini Five curette. Methods A randomised, controlled clinical trial was conducted with 120 participants clinically diagnosed with chronic periodontitis. Participants were equally randomised into four groups, with parallel treatment assignment of scaling and root planning using Gracey Curettes, After five and Mini five curette, and a control group with no instrumentation. Mobile teeth of these patients were then extracted atraumatically and analysed under a Scanning Electron Microscope and graded for "Roughness and Loss of Tooth substance index" and "Smear layer index." Cross Tabulation was made between the test groups (Control, Gracey Curette, After five, and Mini Five) versus "Roughness and Loss of Tooth substance Index" and "Smear Layer Index." A Chi-square test with Bonferroni correction was used to determine the graded distribution among the groups. Results In the control group, 73.3% of the teeth showed grade 1 roughness. In the Gracey group, 56.7% showed grade 2 roughness; in the After 5 group, 70% showed grade 3 roughness; in the Mini 5 group, 76.7% showed grade 3 roughness. A significant association was found between roughness scores and the use of individual instruments. Regarding smear layer formation, 46.7% of teeth showed a grade 4 smear layer in the control group. 50% of teeth showed grade 2 smear layer thickness in the Gracey group. In the After 5 group, 73.3% of teeth showed a grade 1 smear layer, while in the Mini 5 group, 80.0% showed a grade 1 smear layer. The use of individual instruments was significantly associated with the smear layer scores. Conclusion Gracey curettes produced relatively smoother root surfaces with less smear layer formation than After Five and Mini Five curettes, which produced relatively more roughened root surfaces with thicker smear layer formation. Trial registration ID: ClinicalTrials.gov Identifier: NCT04216966 Date of Registration: January 3, 2020.
    Materialart: Online-Ressource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-022-02268-1
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 2091511-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    A placebo‐controlled randomized clinical trial of antibiotics versus probiotics as an adjuvant to nonsurgical periodontal treatment among smokers with Stage III, Grade C generalized periodontitis
    Wiley ; 2023
    In:  Clinical Advances in Periodontics Vol. 13, No. 3 ( 2023-09), p. 197-204
    Details
    In: Clinical Advances in Periodontics, Wiley, Vol. 13, No. 3 ( 2023-09), p. 197-204
    Kurzfassung: Probiotics are viable microorganisms, which if delivered in appropriate dose can provide health benefits. Lactobacillus reuteri (DM17938+ATCC PTA 5289) has been recommended as a safe choice for probiotics. The objective of this study is to compare the improvement in the periodontal parameters amongst smokers with generalized periodontitis with Stage III, Grade C treated with nonsurgical periodontal treatment (NSPT) to which either an antibiotics or probiotics were given as an adjuvant. Methods Sixty smokers with Stage III, Grade C generalized periodontitis were randomized in two groups after taking informed consent. Periodontal parameters including bleeding on probing (BOP), probing depth (PD), attachment loss (AL), gingival index (GI), and plaque index (PI) were recorded. Group 1 received (after NSPT and oral hygiene instructions) amoxicillin and metronidazole for 7 days and a placebo for probiotics for 30 days. Group 2 was provided (after NSPT and oral hygiene instructions) with one tablet of Lactobacillus reuteri probiotics (2 × 10 8 CFU) twice daily for 30 days and placebo antibiotics for 7 days. The periodontal parameters were recorded again at 1‐ and 3‐month follow‐ups as outcome variables. Mean, standard deviation, and confidence interval were reported using SPSS 20.0. Results A statistically significant clinical improvement in the PD, BOP, PI, and GI were observed in both the groups at 3‐month follow‐up. However, the AL remained unchanged in both the groups. Conclusions Administration of probiotics and antibiotics along with NSPT yield statistically significant differences in PD and BOP from baseline to 3‐month follow‐up. However, between the group differences were not statistically significant for the periodontal parameters (AL, PD, and BOP).
    Materialart: Online-Ressource
    ISSN: 2573-8046 , 2163-0097
    URL: Issue
    URL: Article
    DOI: 10.1002/cap.v13.3
    DOI: 10.1002/cap.10253
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2670204-6
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  • 6
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    Relation of salivary MMP-8 with oral submucous fibrosis and oral squamous cell carcinoma: a cross sectional analytical study
    BMJ ; 2022
    In:  BMJ Open Vol. 12, No. 12 ( 2022-12), p. e060738-
    Details
    In: BMJ Open, BMJ, Vol. 12, No. 12 ( 2022-12), p. e060738-
    Kurzfassung: We aim to evaluate salivary matrix metalloproteinases (MMP-8) levels in oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) for the purpose of diagnosis at the early stage via non-invasive method. Setting The study was multicentre, carried out at a tertiary care hospital in Karachi, Pakistan. Participants A total 60 participants of any age, sex and ethnicity were randomly selected for the purpose of this study. Patients demonstrating clinical evidence of OSF and biopsy-proven cases of OSCC were included. Patients with indeterminate histopathological report, immunodeficiency, autoimmune disorder, chronic medical and periodontal disease (periodontal depth greater than 5 mm) and individuals with interincisal mouth opening greater than 35 mm were excluded from the study. Interventions Salivary MMP-8 levels were observed in OSF, healthy and OSCC groups by using ELISA. One way analysis of variance was applied to establish whether MMP-8 levels of disease-free individuals and patients suffering from OSF and OSCC differed from each other. Results Statistically significant difference in salivary MMP-8 expression in diseased and control group was observed. MMP-8 levels in OSCC (0.64 ng/mL) and OSF (0.66 ng/mL) were underexpressed as compared with healthy participants (7.9 ng/mL). Conclusion MMP-8 levels were underexpressed in OSCC and OSF patients as compared with controls, which imply that MMP-8 level has an inverse relation with OSCC and OSF.
    Materialart: Online-Ressource
    ISSN: 2044-6055 , 2044-6055
    URL: Article
    DOI: 10.1136/bmjopen-2021-060738
    Sprache: Englisch
    Verlag: BMJ
    Publikationsdatum: 2022
    ZDB Id: 2599832-8
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  • 7
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    “Clinical comparison of bond failure rate between two types of mandibular canine-canine bonded orthodontic retainers- a randomized clinical trial”
    Springer Science and Business Media LLC ; 2020
    In:  BMC Oral Health Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Kurzfassung: Bonded retainers are widely used as they are esthetically pleasing, easily acceptable, provide greater stability, compliance free and causes no soft tissue irritation and speech problems. Though, fracture and bond failure are their shortcomings. Therefore, the objectives of this study were to evaluate the number of bond failures and type of failure pattern between two types of mandibular canine-canine bonded retainers. Methods Total 60 subjects were recruited initially and were assessed for eligibility, out of which 6 were excluded and 2 were lost to follow up. They were randomly divided into two groups. Fiber reinforced composite (FRC) retainers were inserted in group 1 subjects while group 2 subjects received multistranded stainless steel (MSW) retainers. The subjects were recalled after every 3 months over a period of 1 year. Bond failure rate and failure pattern based on adhesive remnant index were evaluated at each visit. The bond failure rate and failure pattern were compared between the two retainers by using Chi-square test. Results The bond failure rates were 42.94% for FRC retainer and 31.41% for MSW retainer. Hence, total number of bond failures in both retainers were 37.17%. The difference of bond failure between two groups was statistically significant ( p  = 0.012). Type “0” failure pattern was detected commonly with both types of retainers ( p   〈   0.001). Conclusion Our findings indicate that multistranded stainless steel wire retainer is a superior option to be used for fixed lingual retention in mandibular arch as it exhibited lower bond failure as compared to fiber reinforced composite retainer. Adhesive failure is the most common type of bond failure observed with both types of fixed retainers. Trial registration ID NCT03881813 ( https://clinicaltrials.gov/ ); March 19, 2019, retrospective registration.
    Materialart: Online-Ressource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-020-01167-7
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2020
    ZDB Id: 2091511-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Associations of early childhood caries with salivary beta defensin-3 and childhood anemia: a case–control study
    Springer Science and Business Media LLC ; 2021
    In:  BMC Oral Health Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Oral Health, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Kurzfassung: Human beta defensin-3 (HβD-3) is an antimicrobial peptide present in saliva that protects tooth surfaces from microbial attack. These peptides are part of innate immunity so levels may be affected by different systemic diseases like anemia. Therefore, anemia may predispose an affected child to an increased risk of dental caries. The objectives of this study were to determine the association of early childhood caries (ECC) with HβD-3 levels and observe the association of HβD-3 levels with childhood anemia. Methods A total of 80 children admitted in a pediatric medical ward, age 48–71 months, of either sex were included in the study. The included children were categorized as cases (children with ECC n = 40) and controls (children without ECC n = 40). Children were further segregated into the anemic and non-anemic sub-groups based on the hospital record of hemoglobin level. The salivary concentration of HβD-3 was measured by Enzyme-Linked Immuno-sorbent assay (ELISA). IBM SPSS version 20 software was used for statistical analysis. Two sample t-test and one-way ANOVA were used to compare mean values while spearman was used for correlations at p   〈  0.05. Results The mean Salivary HβD-3 level in cases (8.87 ± 4.30) was significantly higher ( p  = 0.042) as compared to controls (7.23 ± 2.57). Salivary HβD-3 level in patients with caries and without anemia was highest (10.80 ± 4.50) whereas salivary HβD-3 level in the presence of caries and anemia was lowest (6.94 ± 3.13) amongst all groups. This difference was statistically significant ( p  = 0.001). Salivary HβD-3 level was found to be moderately correlated with cases ( p  = 0.002). An inverse correlation was found between salivary HβD-3 level and anemia (r = -0.479, p  = 0.002). Conclusion Anemia may affect the innate immunity of children, and may result in a decreased level of salivary HβD3, thus increasing vulnerability to decay.
    Materialart: Online-Ressource
    ISSN: 1472-6831
    URL: Article
    DOI: 10.1186/s12903-021-01810-x
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 2091511-1
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  • 9
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    Dietary Practices, Addictive Behavior and Bowel Habits and Risk of Early Onset Colorectal Cancer: a Case Control Study
    Asian Pacific Organization for Cancer Prevention ; 2015
    In:  Asian Pacific Journal of Cancer Prevention Vol. 16, No. 17 ( 2015-12-03), p. 7967-7973
    Details
    In: Asian Pacific Journal of Cancer Prevention, Asian Pacific Organization for Cancer Prevention, Vol. 16, No. 17 ( 2015-12-03), p. 7967-7973
    Materialart: Online-Ressource
    ISSN: 1513-7368
    URL: Article
    DOI: 10.7314/APJCP.2015.16.17.7967
    Sprache: Englisch
    Verlag: Asian Pacific Organization for Cancer Prevention
    Publikationsdatum: 2015
    ZDB Id: 2218955-5
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  • 10
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    Intrarater reliability of cervical range of motion device among adults with and without chronic non-specific neck pain
    Pakistan Medical Association ; 2023
    In:  Journal of the Pakistan Medical Association Vol. 73, No. 10 ( 2023-09-13), p. 2017-2022
    Details
    In: Journal of the Pakistan Medical Association, Pakistan Medical Association, Vol. 73, No. 10 ( 2023-09-13), p. 2017-2022
    Kurzfassung: Objectives: To evaluate the intrarater reliability of the cervical range of motion device among adults with and without chronic non-specific neck pain. Method: The analytical, cross-sectional study was conducted from January to March 2019 at the Sindh Institute of Physical Medicine and Rehabilitation, Karachi, and comprised healthy adults with no neck pain in the preceding 6 months in Group A, and adults of either gender with chronic non-specific neck pain for 〉 3 months in Group B. The two groups were further divided into age groups 21-30 years, 31-40 years and 41-50 years. A cervical range of motion device was used to measure the range of flexion, extension, right and left lateral flexion and right and left rotation of all the subjects. The measurements were taken by a single tester on day-1 and day-3 to assess the intrarater reliability. Data was analysed using SPSS 26. Results: Of the 60 subjects, there were 30(50%) in each of the two groups. Within the groups, there were 10(33.3%) subjects in each of the 3 age subgroups. Overall, there were 27(45%) males and 33(55%) females. In Group A, the intraclass correlation coefficient values for all cervical ranges were between 0.81 and 0.99, whereas in Group B, the values ranged from 0.64 to 0.88. The intraclass correlation coefficient values yielded good to excellent agreement in both groups ( 〉 0.75) except for left lateral flexion in Group B (p=0.64), and all the values were statistically significant (p 〈 0.05). Conclusion: There was good to excellent intrarater reliability of cervical range of motion device in adults with and without chronic non-specific neck pain. Key Words: Reliability, Range of motion, Spinal column, Non-specific neck pain.
    Materialart: Online-Ressource
    ISSN: 0030-9982
    URL: Article
    DOI: 10.47391/JPMA.9551
    Sprache: Unbekannt
    Verlag: Pakistan Medical Association
    Publikationsdatum: 2023
    ZDB Id: 2128872-0
    Standort Signatur Einschränkungen Verfügbarkeit
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