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  • 1
    Online Resource
    Online Resource
    American Academy of Pediatrics (AAP) ; 2017
    In:  Pediatrics Vol. 139, No. 2 ( 2017-02-01)
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 139, No. 2 ( 2017-02-01)
    Abstract: We examined chronic conditions, functional limitations, and special health care needs in extremely preterm children (EPT; 23–25 weeks’ gestation) born between 1992 and 1998 at 2 Swedish tertiary care centers that offered regional and active perinatal care to all live-born EPT infants. METHODS: Of 134 surviving EPT children, 132 (98%) were assessed at 10 to 15 years of age alongside 103 term-born controls. Identification of children with functional limitations and special health care needs was based on a questionnaire administered to parents. Categorization of medical diagnoses and developmental disabilities was based on child examinations, medical record reviews, and parent questionnaires. RESULTS: In logistic regression analyses adjusting for social risk factors and sex, the EPT children had significantly more chronic conditions than the term-born controls, including functional limitations (64% vs 6%; odds ratio [OR], 15; 95% confidence interval [CI] , 6.1–37.2; P & lt; .001), compensatory dependency needs (60% vs 29%; OR, 3.8; 95% CI, 2.2–6.6; P & lt; .001), and services above those routinely required by children (64% vs 25%; OR, 5.4; 95% CI, 3.0–9.6; P & lt; .001). Specific diagnoses and disabilities for the EPT group versus controls included cerebral palsy (9.1% vs 0%; P & lt; .001), asthma (21.2% vs 6.8%; P = 001), IQ & lt; –2 SD (31.1% vs 4.9%; P & lt; .001), poor motor skills without neurosensory impairment (21.9% vs 1.9%; P & lt; .001), and psychiatric conditions (15.2% vs 1.9%; P & lt; .001). CONCLUSIONS: Adolescents born EPT have considerable long-term health and educational needs. Few had severe impairments that curtailed major activities of daily life.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2017
    detail.hit.zdb_id: 1477004-0
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  • 2
    Online Resource
    Online Resource
    American Academy of Pediatrics (AAP) ; 2011
    In:  Pediatrics Vol. 127, No. 5 ( 2011-05-01), p. e1247-e1257
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 127, No. 5 ( 2011-05-01), p. e1247-e1257
    Abstract: Uncertainty continues regarding the extent to which neonatal morbidities predict poor long-term outcome and functional abilities in extremely preterm infants. OBJECTIVE: The goal of this study was to determine the impact of bronchopulmonary dysplasia (BPD), ultrasonographic signs of brain injury, and severe retinopathy of prematurity (ROP) on 11-year outcomes in infants born at & lt;26 weeks' gestation. METHODS: A total of 247 infants were born alive before 26 completed weeks of gestation from 1990 through 1992 in all of Sweden, and 98 (40%) survived to a postmenstrual age of 36 weeks. Main outcome measures were (1) poor outcome, defined as combined end point of death after 36 weeks' postmenstrual age or survival with at least 1 major disability at 11 years, and (2) consequences of chronic conditions in the survivors according to a validated instrument administered to parents. RESULTS: Brain injury and severe ROP but not BPD correlated independently with poor outcome at 11 years of age. Among children who were free from BPD, brain injury, and severe ROP, 10% had a poor outcome. Corresponding rates with any 1, any 2, and all 3 neonatal morbidities were 19%, 58%, and 80%, respectively. Multivariate analysis revealed that brain injury and severe ROP were associated with high rates of consequences of chronic conditions. CONCLUSIONS: In infants born extremely preterm who survive to a postmenstrual age of 36 weeks, severe ROP and brain injury separately predict the risk of death or major disability at 11 years of age. Thus, continued research to determine how to prevent these complications of prematurity is critical.
    Type of Medium: Online Resource
    ISSN: 0031-4005 , 1098-4275
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 2011
    detail.hit.zdb_id: 1477004-0
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  • 3
    In: BMC Pulmonary Medicine, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Diagnosis of lower respiratory tract infections (LRTI) depends on the presence of clinical, radiological and microbiological findings. Endotracheal suction aspirate (ETSA) is the commonest respiratory sample sent for culture from intubated patients. Very few studies have compared quantitative and semi-quantitative processing of ETSA cultures for LRTI diagnosis. We determined the diagnostic accuracy of quantitative and semi-quantitative ETSA culture for LRTI diagnosis, agreement between the quantitative and semi quantitative culture techniques and the yield of respiratory pathogens with both methods. Methods This was a cross-sectional study conducted at the Aga Khan University clinical laboratory, Karachi, Pakistan. One hundred and seventy-eight ETSA samples sent for routine bacteriological cultures were processed quantitatively as part of regular specimen processing method and semi-quantitatively. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy was calculated for both methods using clinical diagnosis of pneumonia as reference standard. Agreement between the quantitative and semi quantitative methods was assessed via the kappa statistic test. Pathogen yield between the two methods was compared using Pearson’s chi-square test. Results The quantitative and semi-quantitative methods yielded pathogens in 81 (45.5%) and 85 (47.8%) cases respectively. There was complete concordance of both techniques in 155 (87.1%) ETSA samples. No growth was observed in 45 (25.3%) ETSA specimens with quantitative culture and 37 (20.8%) cases by semi-quantitative culture. The diagnostic accuracy of both techniques were comparable; 64.6% for quantitative and 64.0% for semi-quantitative culture. The kappa agreement was found to be 0.84 (95% CI, 0.77–0.91) representing almost perfect agreement between the two methods. Although semi-quantitative cultures yielded more pathogens (47.8%) as compared to quantitative ETSA cultures (45.5%), the difference was only 2.3%. However, this difference achieved statistical (chi-square p -value  〈  0.001) favoring semi-quantitative culture methods over quantitative culture techniques for processing ETSA. Conclusion In conclusion, there is a strong agreement between the performances of both methods of processing ETSA cultures in terms of accuracy of LRTI diagnosis. Semi-quantitative cultures of ETSA yielded more pathogens as compared to quantitative cultures. Although both techniques were comparable, we recommend processing of ETSA using semi-quantitative technique due to its ease and reduced processing time.
    Type of Medium: Online Resource
    ISSN: 1471-2466
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059871-3
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  Feminism & Psychology Vol. 26, No. 2 ( 2016-05), p. 153-169
    In: Feminism & Psychology, SAGE Publications, Vol. 26, No. 2 ( 2016-05), p. 153-169
    Abstract: This article explores the ways in which mothers of extremely premature children make sense of their negative feelings towards their newborn child and their strategies for performing “proper motherhood”. The analysis was guided by discursive psychology and the feminist debate on attachment, mother–infant bonding, and “good motherhood”. The empirical material was created within a sub-study that set out to explore mothers’ and fathers’ experiences of having a premature child and was part of a project investigating the need for support for premature children and their families. Parents were interviewed about the pregnancy, their experiences of the birth and hospital period, the process of going home, the experiences of pre-school and school, and thoughts about the future. The stories of four mothers, which dealt with negative feelings towards their child and the guilt and distress related to this, were selected for analysis. The mothers handled their troubled positions as subjects unable to feel “motherly love” by referring to notions of attachment and bonding, and good motherhood as being loving and caring. Yet, the mothers also talked about motherhood as being socially constructed, as duties that can be performed without the “right motherly feelings”, and as something that men could also perform.
    Type of Medium: Online Resource
    ISSN: 0959-3535 , 1461-7161
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1500139-8
    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2013
    In:  Journal of Developmental & Behavioral Pediatrics Vol. 34, No. 5 ( 2013-06), p. 344-352
    In: Journal of Developmental & Behavioral Pediatrics, Ovid Technologies (Wolters Kluwer Health), Vol. 34, No. 5 ( 2013-06), p. 344-352
    Type of Medium: Online Resource
    ISSN: 0196-206X
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2013
    detail.hit.zdb_id: 2062814-6
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  • 6
    In: JAMA Pediatrics, American Medical Association (AMA), Vol. 172, No. 8 ( 2018-08-01), p. 765-
    Type of Medium: Online Resource
    ISSN: 2168-6203
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2018
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  • 7
    In: Materials Science and Engineering: C, Elsevier BV, Vol. 109 ( 2020-04), p. 110554-
    Type of Medium: Online Resource
    ISSN: 0928-4931
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2012160-X
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  • 8
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 1998
    In:  Journal of Pediatric Gastroenterology & Nutrition Vol. 27, No. 5 ( 1998-11), p. 560-567
    In: Journal of Pediatric Gastroenterology & Nutrition, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 5 ( 1998-11), p. 560-567
    Type of Medium: Online Resource
    ISSN: 0277-2116
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1998
    detail.hit.zdb_id: 2078835-6
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  • 9
    In: Acta Paediatrica, Wiley, Vol. 102, No. 6 ( 2013-06), p. 625-634
    Type of Medium: Online Resource
    ISSN: 0803-5253
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1492629-5
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  • 10
    In: Neonatology, S. Karger AG, Vol. 117, No. 1 ( 2020), p. 80-87
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 At term-equivalent age, infants born prematurely are shorter, lighter and have more adipose tissue compared to term counterparts. Little is known on whether the differences in body composition persist in later age. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We prospectively recruited 33 preterm infants ( & #x3c;32 weeks gestational age, mean gestational age 28.1 weeks) and 69 term controls. Anthropometry and body composition (air displacement plethysmography) were monitored up to 4 months of age. Nutrient intakes from preterm infants were collected from clinical records. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At 4 months of age preterm infants were lighter and shorter than term controls (mean weight-for-age 〈 i 〉 z- 〈 /i 〉 score: –0.73 vs. 0.06, 〈 i 〉 p 〈 /i 〉 = 0.001; mean length-for-age 〈 i 〉 z 〈 /i 〉 -score: –1.31 vs. 0.29, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001). The significantly greater percentage of total body fat seen in preterm infants at term-equivalent age (20.2 vs. 11.7%, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001) was no longer observed at 4 months. A deficit of fat-free mass persisted until 4 months of age (fat-free mass at term-equivalent age: 2.71 vs. 3.18 kg, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001; at 4 months: 4.3 vs. 4.78 kg, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001). The fat mass index and fat-free mass index (taking length into account) did not differ between the groups. Nutrition had little effect on body composition. Higher protein intake at week 2 was a negative predictor of fat-free mass at discharge. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 At 4 months corrected age, preterm infants were both lighter and shorter than term controls and the absolute fat-free mass deficit remained until this age. Little effect of nutrition on body composition was observed.
    Type of Medium: Online Resource
    ISSN: 1661-7800 , 1661-7819
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2403535-X
    SSG: 12
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