In:
International Journal of Cancer, Wiley, Vol. 138, No. 4 ( 2016-02-15), p. 1013-1023
Abstract:
What's new? As a key component of tumor stroma, tumor‐associated fibroblasts (TAFs) promote malignant growth, angiogenesis, invasion, and metastasis. Fibroblast activation protein (FAP), a surface protein that is exceedingly expressed in TAFs, could function as an attractive target for cancer therapy in a broad range of cancers. In this study, the authors developed a novel immunotoxin αFAP‐PE38 targeting the nonmalignant compartment of solid tumors and demonstrated its potent antitumor activity as well as the enhanced therapeutic efficacy of this immunotoxin with paclitaxel. These studies pave the way for applying the combination of FAP‐targeting immunotoxin and chemotherapeutic agent as a promising new strategy to enhance clinical application of immunotoxin‐based therapies.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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