In:
Angewandte Chemie, Wiley, Vol. 133, No. 17 ( 2021-04-19), p. 9460-9464
Abstract:
Cephalodiones A–D ( 1 – 4 ), the first example of C 19 ‐norditerpenoid dimers, were isolated and fully characterized from a Cephalotaxus plant. These new skeletal natural products shared a unique tricyclo[6.4.1.1 2,7 ]tetradeca‐3,5,9,11‐tetraene‐13,14‐dione core that was capped in both ends with rigid multicyclic ring systems either C 2 ‐symmetrically or asymmetrically. Compounds 1 – 4 were proposed to be biosynthetically produced by the [6+6]‐cycloaddition of two identical C 19 ‐norditerpenoid troponoids, which was validated by the semisyntheses of dimers 2 – 4 . Moreover, some compounds showed significant inhibition on Th17 cell differentiation.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v133.17
DOI:
10.1002/ange.202015332
Language:
English
Publisher:
Wiley
Publication Date:
2021
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505872-7
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1479266-7
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