In:
Advanced Healthcare Materials, Wiley, Vol. 9, No. 2 ( 2020-01)
Kurzfassung:
Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO 2 nanoplates (H‐MnO 2 ) are demonstrated for achieving not only nucleus‐targeted NIR‐II photothermal therapy (PTT), but also tumor microenvironment (TME) hypoxia relief enhanced photodynamic therapy (PDT). The Pd@Au nanoplates present a photothermal conversion efficiency (PTCE) as high as 56.9%, superior to those PTAs activated in the NIR‐II region such as Cu 9 S 5 nanoparticles (37%), Cu 3 BiS 3 nanorods (40.7%), and Au/Cu 2− x S nanocrystals (43.2%). They further functionalize with transactivator of transcription (TAT) moiety for cell nuclear‐targeting and biodegradable hollow mesoporous MnO 2 (≈100 nm) loaded with photosensitizer Ce6 (TAT‐Pd@Au/Ce6/PAH/H‐MnO 2 ) to construct a hierarchical targeting nanoplatform. The as‐made TAT‐Pd@Au/Ce6/PAH/H‐MnO 2 demonstrates good premature renal clearance escape ability and increased tumor tissue accumulation. It can be degraded in acidic TME and generate O 2 by reacting to endogenous H 2 O 2 to relieve the hypoxia for enhanced PDT, while the released small TAT‐Pd@Au nanoplates can effectively enter into the nucleus to mediate PTT. As a result, a remarkable therapeutic effect is achieved owing to the synergistic PTT/PDT therapy. This hierarchical targeting, TME‐responsive, cytoplasm hypoxia relief PDT, and nuclear NIR‐II PTT synergistic therapy can pave a new avenue for nanomaterials‐based cancer therapy.
Materialart:
Online-Ressource
ISSN:
2192-2640
,
2192-2659
DOI:
10.1002/adhm.201901528
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2020
ZDB Id:
2645585-7
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