In:
International Journal of Cancer, Wiley, Vol. 135, No. 7 ( 2014-10), p. 1517-1530
Abstract:
What's New? Receptor tyrosine kinases (RTKs) of the EGFR family represent valuable therapeutic targets for esophageal squamous cell carcinomas (ESCCs) and/or esophageal adenocarcinomas (EACs). However, there is a lack of studies investigating the cellular mechanisms of action of RTK inhibitors. This study reveals for the first time dimerization of EGFR, HER2 and HER3 in ESCC and EAC in vitro and in situ . EGFR and HER2 overexpression predominantly results in homodimers in ESCCs and EACs, respectively. HER3 is highly expressed in EACs, where it dimerizes with HER2. This suggests previously unconsidered mechanisms of action and may inform response prediction of HER2‐targeting inhibitors in EACs.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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