In:
European Journal of Immunology, Wiley, Vol. 25, No. 5 ( 1995-05), p. 1326-1331
Abstract:
The recognition of antigenic peptides by CD4 + helper T cells is demonstrated here to result in a dramatic (up to 90%) decrease in expression of major histocompatibility complex (MHC) class II molecules on the surface of antigen‐presenting cells (APC). The reduction is selective to the class II isotype presenting the antigen, but if affects both allelic forms of the same isotype in heterozygous APC. The observed MHC down‐regulation requires a specific T cell receptor‐peptide‐class II interaction, a direct contact between T cell and APC, and the involvement of CD2 molecules. These findings have important implications for the regulation of immune response, self tolerance, and autoimmunity.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.1830250529
Language:
English
Publisher:
Wiley
Publication Date:
1995
detail.hit.zdb_id:
1491907-2
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