In:
Diabetic Medicine, Wiley, Vol. 25, No. 11 ( 2008-11), p. 1366-1369
Abstract:
Background In Type 1 diabetes mellitus (DM), it has been suggested that autonomic nervous system dysfunction (NAD) impairs lung diffusion capacity. Heart rate variability (HRV), a measure of cardiac autonomic function, is a sensitive method of detecting NAD. To our knowledge, no previous study has assessed whether cardiac sympatho‐vagal balance is associated with lung diffusion capacity in diabetes. Methods Twenty Type 1 DM patients without pulmonary abnormalities and systemic NAD underwent measurement of lung diffusion capacity for carbon monoxide (DLCO) by single‐breath method and assessment of cardiac autonomic function by HRV analysis on 24‐h electrocardiographic Holter recordings. Results Standard respiratory function tests and peripheral autonomic tests were normal in all patients. DLCO was lower than normal reference values in six patients (30%). DLCO correlated significantly with most HRV variables, independent of the clinical and laboratory variables. The strongest correlation was found with standard deviation of all RR intervals (SDNN; r = 0.62, P = 0.003) in the time domain and low frequency (LF) power ( r = 0.73, P 〈 0.001) in the frequency domain. Conclusions In Type 1 diabetes, a significant association exists between cardiac NAD and reduced DLCO in the absence of clinical respiratory and autonomic abnormalities. Thus, NAD may be involved in the early reduction of DLCO in these patients, possibly through abnormalities in the regulation of pulmonary blood flow at the microvascular level.
Type of Medium:
Online Resource
ISSN:
0742-3071
,
1464-5491
DOI:
10.1111/dme.2008.25.issue-11
DOI:
10.1111/j.1464-5491.2008.02571.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2019647-7
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