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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 2001
    In:  The American Journal of Cardiology Vol. 88, No. 11 ( 2001-12), p. 1221-1224
    In: The American Journal of Cardiology, Elsevier BV, Vol. 88, No. 11 ( 2001-12), p. 1221-1224
    Type of Medium: Online Resource
    ISSN: 0002-9149
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2001
    detail.hit.zdb_id: 80014-4
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  • 2
    In: The Astrophysical Journal, American Astronomical Society, Vol. 864, No. 1 ( 2018-09-01), p. 43-
    Abstract: We present detailed chemical abundances of three new bright ( V ∼ 11), extremely metal-poor ([Fe/H] ∼ −3.0), r -process-enhanced halo red giants based on high-resolution, high-S/N Magellan /MIKE spectra. We measured abundances for 20–25 neutron-capture elements in each of our stars. J1432−4125 is among the most r -process-rich r -II stars, with [Eu/Fe] = +1.44 ± 0.11. J2005−3057 is an r -I star with [Eu/Fe] = +0.94 ± 0.07. J0858−0809 has [Eu/Fe]  = +0.23 ± 0.05 and exhibits a carbon abundance corrected for an evolutionary status of [C/Fe] corr  = +0.76, thus adding to the small number of known carbon-enhanced r -process stars. All three stars show remarkable agreement with the scaled solar r -process pattern for elements above Ba, consistent with enrichment of the birth gas cloud by a neutron star merger. The abundances for Sr, Y, and Zr, however, deviate from the scaled solar pattern. This indicates that more than one distinct r -process site might be responsible for the observed neutron-capture element abundance pattern. Thorium was detected in J1432−4125 and J2005−3057. Age estimates for J1432−4125 and J2005−3057 were adopted from one of two sets of initial production ratios each by assuming the stars are old. This yielded individual ages of 12 ± 6 Gyr and 10 ± 6 Gyr, respectively.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2018
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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  • 3
    Online Resource
    Online Resource
    American Astronomical Society ; 2017
    In:  The Astrophysical Journal Vol. 847, No. 2 ( 2017-10-01), p. 142-
    In: The Astrophysical Journal, American Astronomical Society, Vol. 847, No. 2 ( 2017-10-01), p. 142-
    Abstract: We present new ultra-metal-poor stars parameters with [Fe/H] 〈 −4.0 based on line-by-line non-local thermodynamic equilibrium (NLTE) abundances using an up-to-date iron model atom with a new recipe for non-elastic hydrogen collision rates. We study the departures from LTE in their atmospheric parameters and show that they can grow up to ∼1.00 dex in [Fe/H], ∼150 K in and ∼0.5 dex in log g toward the lowest metallicities. Accurate NLTE atmospheric stellar parameters, in particular [Fe/H] being significantly higher, are the first step to eventually providing full NLTE abundance patterns that can be compared with Population III supernova nucleosynthesis yields to derive properties of the first stars. Overall, this maximizes the potential of these likely second-generation stars to investigate the early universe and how the chemical elements were formed.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2017
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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  • 4
    In: The Astrophysical Journal, American Astronomical Society, Vol. 948, No. 2 ( 2023-05-01), p. 122-
    Abstract: The ages of the oldest stars shed light on the birth, chemical enrichment, and chemical evolution of the universe. Nucleocosmochronometry provides an avenue to determining the ages of these stars independent from stellar-evolution models. The uranium abundance, which can be determined for metal-poor r -process enhanced (RPE) stars, has been known to constitute one of the most robust chronometers known. So far, U abundance determination has used a single U ii line at λ 3859 Å. Consequently, U abundance has been reliably determined for only five RPE stars. Here, we present the first homogeneous U abundance analysis of four RPE stars using two novel U ii lines at λ 4050 Å and λ 4090 Å, in addition to the canonical λ 3859 Å line. We find that the U ii lines at λ 4050 Å and λ 4090 Å are reliable and render U abundances in agreement with the λ 3859 U abundance, for all of the stars. We, thus, determine revised U abundances for RPE stars, 2MASS J09544277+5246414, RAVE J203843.2–002333, HE 1523–0901, and CS 31082–001, using multiple U ii lines. We also provide nucleocosmochronometric ages of these stars based on the newly derived U, Th, and Eu abundances. The results of this study open up a new avenue to reliably and homogeneously determine U abundance for a significantly larger number of RPE stars. This will, in turn, enable robust constraints on the nucleocosmochronometric ages of RPE stars, which can be applied to understand the chemical enrichment and evolution in the early universe, especially of r -process elements.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2023
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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  • 5
    Online Resource
    Online Resource
    American Astronomical Society ; 2018
    In:  The Astrophysical Journal Vol. 863, No. 2 ( 2018-08-20), p. 168-
    In: The Astrophysical Journal, American Astronomical Society, Vol. 863, No. 2 ( 2018-08-20), p. 168-
    Abstract: We present a new iron abundance analysis of the hyper metal-poor star HE 1327−2326, based on Fe ii lines detected in its UV spectral range for the first time. In a Cosmic Origins Spectrograph (COS) spectrum, five new Fe ii lines could be measured. A Si i line was also detected for the first time. We determine a 1D local thermodynamic equilibrium (LTE) Fe ii abundance of [Fe ii /H] = −5.99 ± 0.25. We also investigate departures from LTE for both Fe i and Fe ii lines. Guided by 3D non-LTE (NLTE) analyses of other well-studied metal-poor stars, we identify potential “residual” 3D effects in HE 1327−2326 arising from the absence of full 3D NLTE Fe calculations. Accordingly, we employ measurements of 10 weak Fe i lines previously detected in an optical spectrum of HE 1327−2326, as no Fe i lines are detectable in our UV spectrum. Following our previous work, we adopt the 1D NLTE Fe i abundance of  = −5.20 ± 0.12 for HE 1327−2326. Adopting a value based on the optical Fe i rather than UV lines was heavily informed by our extensive investigation of model atmosphere and radiative transfer effects on different lines across the entire UV–optical wavelength range. An iron abundance of  = −5.20 ± 0.12 is only 0.2 dex higher than what was used in previous studies. Accordingly, no previous conclusions regarding the nature of the star are affected.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2018
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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  • 6
    In: The Astrophysical Journal, American Astronomical Society, Vol. 865, No. 2 ( 2018-10-01), p. 129-
    Abstract: We present a detailed abundance analysis of the bright ( V  = 9.02), metal-poor ([Fe/H] = −1.47 ± 0.08) field red horizontal-branch star HD 222925, which was observed as part of an ongoing survey by the R -Process Alliance. We calculate stellar parameters and derive abundances for 46 elements based on 901 lines examined in a high-resolution optical spectrum obtained using the Magellan Inamori Kyocera Echelle spectrograph. We detect 28 elements with 38 ≤  Z  ≤ 90; their abundance pattern is a close match to the solar r -process component. The distinguishing characteristic of HD 222925 is an extreme enhancement of r -process elements ([Eu/Fe] = +1.33 ± 0.08, [Ba/Eu]  = −0.78 ± 0.10) in a moderately metal-poor star, so the abundance of r -process elements is the highest ([Eu/H] = −0.14 ± 0.09) in any known r -process-enhanced star. The abundance ratios among lighter ( Z  ≤ 30) elements are typical for metal-poor stars, indicating that production of these elements was dominated by normal Type II supernovae, with no discernible contributions from Type Ia supernovae or asymptotic giant branch stars. The chemical and kinematic properties of HD 222925 suggest it formed in a low-mass dwarf galaxy, which was enriched by a high-yield r -process event before being disrupted by interaction with the Milky Way.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2018
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
    Location Call Number Limitation Availability
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  • 7
    In: The Astrophysical Journal, American Astronomical Society, Vol. 897, No. 1 ( 2020-07-01), p. 78-
    Abstract: We report on the spectroscopic analysis of RAVE J183013.5−455510 , an extremely metal-poor star, highly enhanced in CNO, and with discernible contributions from the rapid neutron-capture process. There is no evidence of binarity for this object. At  = −3.57, this star has one of the lowest metallicities currently observed, with 18 measured abundances of neutron-capture elements. The presence of Ba, La, and Ce abundances above the solar system r -process predictions suggests that there must have been a non-standard source of r -process elements operating at such low metallicities. One plausible explanation is that this enhancement originates from material ejected at unusually high velocities in a neutron star merger event. We also explore the possibility that the neutron-capture elements were produced during the evolution and explosion of a rotating massive star. In addition, based on comparisons with yields from zero-metallicity faint supernova, we speculate that RAVE J1830−4555 was formed from a gas cloud pre-enriched by both progenitor types. From analysis based on Gaia DR2 measurements, we show that this star has orbital properties similar to the Galactic metal-weak thick-disk stellar population.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2020
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
    Location Call Number Limitation Availability
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  • 8
    In: The Astrophysical Journal, American Astronomical Society, Vol. 898, No. 1 ( 2020-07-01), p. 40-
    Abstract: We report the discovery of J1521−3538, a bright ( V  = 12.2), very metal-poor ([Fe/H] = −2.8) strongly r -process-enhanced field horizontal branch star, based on a high-resolution, high signal-to-noise Magellan/MIKE spectrum. J1521−3538 shows the largest r -process element overabundance in any known r -process-enhanced star, with [Eu/Fe] = +2.2, and its chemical abundances of 22 neutron-capture elements closely match the scaled solar r -process pattern. J1521−3538 is also one of few known carbon-enhanced metal-poor stars with r -process enhancement (CEMP- r stars), as found after correcting the measured C abundance for the star’s evolutionary status. We propose to extend the existing classification of moderately enhanced ( ) r -I and strongly r -process enhanced ( ) r -II stars to include an r -III class, for r -process stars such as J1521−3538, with and , or times the solar ratio of europium to iron. Using cosmochronometry, we estimate J1521−3538 to be and , using two different sets of initial production ratios. These ages are based on measurements of the Th line at 4019 Å and other r -process element abundances. This is broadly consistent with the old age of a low-mass, metal-poor field red horizontal branch star. J1521−3538 likely originated in a low-mass dwarf galaxy that was later accreted by the Milky Way, as evidenced by its highly eccentric orbit.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2020
    detail.hit.zdb_id: 2960-9
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
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  • 9
    In: Blood, American Society of Hematology, Vol. 110, No. 11 ( 2007-11-16), p. 734-734
    Abstract: Dasatinib (SPRYCEL®) is 325-fold more potent than imatinib against BCR-ABL in vitro and binds to BCR-ABL in both the inactive and active, oncogenic conformations. Dasatinib has been shown to be an effective treatment option for patients with imatinib-resistant or -intolerant chronic-phase chronic myelogenous leukemia (CP-CML). Here we report the extended follow-up of START-C, a 75-center, international study of dasatinib in 387 patients with CP-CML with resistance (n=288) or intolerance (n=99) to imatinib. Recruitment took place from February to July 2005. Dasatinib was administered on a 70-mg BID regimen; dose escalation (90 mg BID) or reduction (50 or 40 mg BID) were allowed for lack of response or toxicity, respectively. Median time from diagnosis of CML was 61 mo (range 32–50). Prior therapy included interferon-α in 65% of patients and stem-cell transplantation in 10%; 55% had received prior imatinib doses 〉 600 mg and 53% treatment with imatinib for 〉 3 years. Best response to prior imatinib therapy was complete hematologic response (CHR) in 82%, and complete (CCyR) and partial cytogenetic response (PCyR) in 19% and 18%, respectively. With a median follow-up of 15.2 mo, CHR was attained in 91% of patients (95% CI 87–93%), major cytogenetic response (MCyR) in 59% (95% CI 54–64%) (52% imatinib-resistant, 80% imatinib-intolerant), and CCyR in 49% (40% imatinib-resistant; 75% imatinib-intolerant). For patients with no prior MCyR to imatinib, 42% achieved a MCyR with dasatinib. A MCyR rate of 59% was recorded for patients with baseline BCR-ABL mutations; responses were seen across all mutations with the exception of T315I. MCyRs were durable, with only 7 of the 230 patients who had achieved a MCyR with dasatinib losing this response. Major molecular response rate (ie, a BCR-ABL/ABL ratio of 〈 0.1% according to the international scale by RQ-PCR) at 12 mo was 25%. Progression-free survival at 15 mo was 90% while overall survival was 96%. Dose interruptions were required for 87% of patients and dose reduction for 73%; the average daily dose administered was 101 mg (range 11–171). Reports of grade 3–4 thrombocytopenia and neutropenia were documented for 48% and 49% of patients, respectively. Non-hematologic toxicity consisted primarily of diarrhea (37%), headache (32%), fatigue (31%), and dyspnea (30%). Pleural effusion was experienced by 27% of patients; this was categorised as grade 1–2 in 21% and grade 3–4 in 6%. Dasatinib-induced cytogenetic responses remain durable in patients with CP-CML resistant or intolerant to imatinib. Updated analyses corresponding to a minimum follow-up of 2 years on all patients will be presented.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2007
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 10
    Online Resource
    Online Resource
    Inderscience Publishers ; 2020
    In:  International Journal of Technology Transfer and Commercialisation Vol. 1, No. 1 ( 2020), p. 1-
    In: International Journal of Technology Transfer and Commercialisation, Inderscience Publishers, Vol. 1, No. 1 ( 2020), p. 1-
    Type of Medium: Online Resource
    ISSN: 1470-6075 , 1741-5284
    Language: English
    Publisher: Inderscience Publishers
    Publication Date: 2020
    detail.hit.zdb_id: 2103724-3
    SSG: 3,2
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