In:
Contact Dermatitis, Wiley, Vol. 77, No. 3 ( 2017-09), p. 151-158
Abstract:
Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. Objectives To identify the current spectrum of contact allergens in these patients. Patients and methods Data of the I nformation N etwork of D epartments of D ermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510). Results Allergic contact dermatitis was diagnosed less frequently in the study group than in the historical control group (25.9% versus 16.9%; p 〈 0.001), and contact sensitization to most allergens had declined. The allergen spectrum, however, was largely unchanged. Important allergens are M yroxylon pereirae (balsam of P eru) (14.8% positive reactions), fragrance mix I (11.4%), lanolin alcohol (7.8%), colophonium (6.6%), neomycin sulfate (5.0%), cetearyl alcohol (4.4%), oil of turpentine (3.1%), and paraben mix (2.6%). Patch testing with additional series showed sensitization to A merchol L ‐101 (9.7%), tert ‐butyl hydroquinone (8.7%), framycetin sulfate (5.0%), and gentamicin sulfate (3.1%). Conclusions Topical preparations for treating the above‐mentioned conditions should not contain fragrances, M yroxylon pereirae , and colophonium. The special allergen spectrum has to be considered in patch testing.
Type of Medium:
Online Resource
ISSN:
0105-1873
,
1600-0536
DOI:
10.1111/cod.2017.77.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2027120-7
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