In:
Case Reports in Internal Medicine, Sciedu Press, Vol. 1, No. 1 ( 2014-02-24), p. 37-
Abstract:
The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy (PFAPA) is a benign, self-limited, auto-inflammatory disorder. The attacks usually start at age 2 to 5 years and cease before the age of 10 years. Affected children grow and develop normally and experience no long-term sequelae. The course of PFAPA syndrome is attenuated by the carrier state of the familial Mediterranean fever (FMF) gene, MEFV. A high rate of MEFV mutations has also been reported in various hemato-lymphoid neoplasms. We describe a 19-year-old woman with PFAPA syndrome in remission who was diagnosed with Hodgkin's lymphoma. Although mutations in the FMF gene were not found in this case, the association of PFAPA syndrome with FMF gene mutations and hematological malignancies is discussed.
Type of Medium:
Online Resource
ISSN:
2332-7251
,
2332-7243
DOI:
10.5430/crim.v1n1p37
Language:
Unknown
Publisher:
Sciedu Press
Publication Date:
2014
Permalink