In:
Research Journal of Chemistry and Environment, World Researchers Associations, Vol. 26, No. 2 ( 2022-01-25), p. 14-22
Abstract:
Cadmium (Cd) is one of the precedence pollutants in the environment which menaces the aquatic organisms. Cd is also shown to have deleterious health impairments causing male and female infertility in humans. In this study, we investigated the role of 7, 8- DHC as a potent rescuer of Cd induced toxicity using zebrafish (Daniorerio) model. The anti-oxidant property of 7,8-DHC was analysed and confirmed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric ion reducing power (FRAP) and hydroxyl radical (OH) assays. Further, we induced Cd toxicity in zebrafish embryos at 100-μM concentration and the intoxicated embryos showed a significantly reduced survival, delayed hatching and phenotypic aberrations at 24, 48, 72 and 96 hours post fertilization (hpf). Similarly, Cd intoxicated embryos showed an expressively increased cardiac function (170 ±1 beats/min and 172± 1 beats/min) at 48 and 60 hpf. Furthermore, the rescuing effect of 7,8-DHC was analysed via treatment of Cd intoxicated embryos at dosage dependent manner. At 100 μg, 7,8-DHC showed significantly reduced heart beat compared to the Cd intoxicated embryos. Moreover, 50 and 100 μg of 7, 8-DHC treated groups showed 103± 1 beats/min and 104±1 beats/min respectively. Histopathological interpretations revealed the rescuing effects on notochordal segmentation at 50 and 100 μg 7, 8-DHC in Cd intoxicated embryos at 96 hpf. Overall, our results clinched that 7, 8-DHC could act as a potent redox scavenger against Cd toxicity.
Type of Medium:
Online Resource
ISSN:
0972-0626
,
2278-4527
DOI:
10.25303/2602rjce1422
Language:
Unknown
Publisher:
World Researchers Associations
Publication Date:
2022
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