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  • 1
    Online Resource
    Online Resource
    Hindering the Synchronization Between miR-486-5p and H19 lncRNA by Hesperetin Halts Breast Cancer Aggressiveness Through Tuning ICAM-1
    Bentham Science Publishers Ltd. ; 2022
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 22, No. 3 ( 2022-02), p. 586-595
    Details
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 22, No. 3 ( 2022-02), p. 586-595
    Abstract: Recently, a novel crosstalk between non-coding RNAs (ncRNAs) has been casted. However, this has been seldom investigated in metastatic BC (mBC). H19 and miR-486-5p role in mBC are controversial. ICAM-1 is a recently recognized metastatic engine in mBC. Natural compounds were recently found to alter ncRNAs/target circuits. Yet, Hesperitin’s modulatory role in altering such circuits has never been investigated in mBC. Objective: The aim of this study is to investigate the impact of hesperitin on miR-486-5p/H19/ICAM-1 axis. Methodology: BC patients (n=20) were recruited in the study. Bioinformatic analysis was performed using different prediction softwares. MDA-MB-231 and MCF-7 cells were cultured and transfected using several oligonucleotides or treated with serial dilutions of hesperitin. RNA was extracted and gene expression analysis was performed using q-RT-PCR. ICAM-1 protein levels were assessed using human ICAM-1 Elisa Kit. Cytotoxic potential of hesperitin against normal cells was assessed by LDH assay. Several functional analysis experiments were performed such as MTT, colony forming and migration assays. Results: The study showed that miR-486-5p and H19 had paradoxical expression profiles in BC patients. miR- 486-5p mimics and H19 siRNAs repressed ICAM-1 and halted mBC hallmarks. A novel crosstalk between miR- 486-5p and H19 was observed highlighting a bi-directional relationship between them. Hesperetin restored the expression of miR-486-5p, inhibited H19 lncRNA and ICAM-1 expression and selectively regressed mBC cell aggressiveness. Conclusion: miR-486-5p and H19 are inter-connected upstream regulators for ICAM-1 building up miR-486- 5p/H19/ICAM-1 axis that has been successfully tuned in mBC cells by hesperitin.
    Type of Medium: Online Resource
    ISSN: 1871-5206
    URL: Article
    DOI: 10.2174/1871520621666210419093652
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Determination of Formaldehyde by HPLC with Stable Precolumn Derivatization in Egyptian Dairy Products
    Hindawi Limited ; 2018
    In:  International Journal of Analytical Chemistry Vol. 2018 ( 2018-11-08), p. 1-5
    Details
    In: International Journal of Analytical Chemistry, Hindawi Limited, Vol. 2018 ( 2018-11-08), p. 1-5
    Abstract: Formaldehyde is one of the most dangerous chemical compounds affecting the human health; exposure to it from food may occur naturally or by intentional addition. In this study a high performance liquid chromatography method for determination of formaldehyde in dairy products was described. The dairy samples were reacted and extracted with a warmed organic solvent in the presence of derivatizing agent 2,4-dinitrophenylhydrazine (DNPH) and formaldehyde; the mixture was centrifuged and followed by diode array detection. The method is validated and gives average recovery of formaldehyde at the three different levels 0.1, 5.0, and 10.0 mg/kg varied between 89% and 96%. The method is linear from the limit of quantification 0.1 mg/kg up to 10 mg/kg levels. This method is intended for formaldehyde analyses in dairy products simply with stable derivatization, minimum residue loss, excellent recovery, and accurate results with a sensitive limit of detection 0.01 mg/kg. 90 dairy samples from milk, cheese, and yogurt were investigated from seven Egyptian governorates and all samples were free from formaldehyde.
    Type of Medium: Online Resource
    ISSN: 1687-8760 , 1687-8779
    URL: Article
    DOI: 10.1155/2018/2757941
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2494714-3
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  • 3
    Online Resource
    Online Resource
    Simple Validated Method for Determination of Deoxynivalenol and Zearalenone in Some Cereals Using High Performance Liquid Chromatography
    Science Alert ; 2012
    In:  American Journal of Food Technology Vol. 7, No. 11 ( 2012-10-15), p. 668-678
    Details
    In: American Journal of Food Technology, Science Alert, Vol. 7, No. 11 ( 2012-10-15), p. 668-678
    Type of Medium: Online Resource
    ISSN: 1557-4571
    URL: Article
    DOI: 10.3923/ajft.2012.668.678
    Language: Unknown
    Publisher: Science Alert
    Publication Date: 2012
    detail.hit.zdb_id: 2236741-X
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  • 4
    Online Resource
    Online Resource
    Green waste recycling of peanuts highly contaminated with aflatoxins in clay brick manufacturing
    Springer Science and Business Media LLC ; 2022
    In:  Bulletin of the National Research Centre Vol. 46, No. 1 ( 2022-12)
    Details
    In: Bulletin of the National Research Centre, Springer Science and Business Media LLC, Vol. 46, No. 1 ( 2022-12)
    Abstract: The safe disposal of green waste is necessary for a clean environment, with the safe disposal of waste contaminated with aflatoxins being of particular importance. This work presents a novel route for utilizing contaminated grains in the production of clay bricks. In this work, the contaminated peanut (P) with aflatoxins (AFs) is divided into two categories: PA is the contaminated peanut kernel (without the outer shell), and PB is contaminated whole peanut grain (with the outer shell). Both of ground PA and PB were used to replace the clay in fired building bricks. The raw materials were characterized using X-ray fluorescence (XRF), X-ray diffraction (XRD), and thermo-gravimetric analyses (TGA). The effectiveness of this approach was evaluated by measuring the effect of the replacement percentage and firing temperature on the properties of the produced building bricks. Results The optimization of the process parameters was performed using central composite design as a tool in the response surface methodology. The ANOVA analysis of the predicted quadratic model elucidated significant models’ terms and adequate precision that emphasizes the applicability of the model to navigate the design space. The results revealed that the optimum conditions are 6% clay replacement and 725 °C firing temperature, resulting in a compressive strength of 109.85 kg cm −2 for clay bricks with PA and 126.33 kg cm −2 for clay bricks with PB. Conclusions The objective of clay replacement by the contaminated peanut is not to improve the clay brick properties but to perform safe disposal of the accumulated contaminated peanut without deviating from the standards. The design of experiment using response surface method enables studying the effect of several factors on the clay brick properties simultaneously. Subsequently, this approach elucidates a sustainable route for accumulated contaminated green peanut waste disposal as the other alternatives have realized risks.
    Type of Medium: Online Resource
    ISSN: 2522-8307
    URL: Article
    DOI: 10.1186/s42269-022-00780-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2946659-3
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  • 5
    Online Resource
    Online Resource
    Food additives and flavourings: Analysis of EU RASFF Notifications from 2000 to 2022
    Elsevier BV ; 2024
    In:  Journal of Food Composition and Analysis ( 2024-2), p. 106137-
    Details
    In: Journal of Food Composition and Analysis, Elsevier BV, ( 2024-2), p. 106137-
    Type of Medium: Online Resource
    ISSN: 0889-1575
    URL: Article
    DOI: 10.1016/j.jfca.2024.106137
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1469801-8
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  • 6
    Online Resource
    Online Resource
    Perindopril Alleviates Inflammation via Cyclooxygenase Inhibition: A Bioinformatics, in vitro and in vivo Evaluation
    Science Alert ; 2023
    In:  International Journal of Pharmacology Vol. 19, No. 3 ( 2023-6-15), p. 428-438
    Details
    In: International Journal of Pharmacology, Science Alert, Vol. 19, No. 3 ( 2023-6-15), p. 428-438
    Type of Medium: Online Resource
    ISSN: 1811-7775
    URL: Article
    DOI: 10.3923/ijp.2023.428.438
    Language: Unknown
    Publisher: Science Alert
    Publication Date: 2023
    detail.hit.zdb_id: 2177288-5
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  • 7
    Online Resource
    Online Resource
    Comparison between Myocardial Glycogen Storage in CABG after Using Blood Cardioplegia versus HTK Solution
    Oxford University Press (OUP) ; 2023
    In:  QJM: An International Journal of Medicine Vol. 116, No. Supplement_1 ( 2023-08-23)
    Details
    In: QJM: An International Journal of Medicine, Oxford University Press (OUP), Vol. 116, No. Supplement_1 ( 2023-08-23)
    Abstract: Inadequate myocardial protection in long ischaemic periods followed by reperfusion is an issue of concern in cardiac surgery. Cardioplegic solutions improve the tolerance to ischaemia and reperfusion by preserving myocardial energy reserves, preventing osmotic and electrolyte imbalances and buffering acidosis. Objective This somewhat surprising given the high number of procedures performed worldwide with this cardioplegic solution. As such, the purpose of this study was to assess the safety of the HTK solution when compared with our standard blood cardioplegia in coronary artery bypass graft operations via assessment of myocardial glycogen storage. Patients and Methods This was a retrospective, convenient, non- randomized study conducted on 40 consecutive patients who underwent isolated elective CABG at department of cardiothoracic surgery at Ain Shams University Hospitals. The aim of the study was to compare early outcomes of Custodiol versus blood cardioplegia in coronary artery bypass graft surgery via assessment of glycogen storage in myocarduim via assessment of myocardial glycogen storage. at Ain Shams University Hospitals. Results There was no statistically significant difference between the two groups of myocardial glycogen storage post-operative. Conclusion There was statistically significant difference between the pre and post-operative in both custodial and blood cardioplegia. There was no statistically significant difference between the two groups of myocardial protection in mortality and morbidity. Custodiol cardioplegia is an easy technique and simple without need of preparation or repeated administration.
    Type of Medium: Online Resource
    ISSN: 1460-2725 , 1460-2393
    URL: Article
    DOI: 10.1093/qjmed/hcad069.110
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1492613-1
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  • 8
    Online Resource
    Online Resource
    Toxicity Evaluation, Oxidative, and Immune Responses of Mercury on Nile Tilapia: Modulatory Role of Dietary Nannochloropsis oculata
    Springer Science and Business Media LLC ; 2024
    In:  Biological Trace Element Research Vol. 202, No. 4 ( 2024-04), p. 1752-1766
    Details
    In: Biological Trace Element Research, Springer Science and Business Media LLC, Vol. 202, No. 4 ( 2024-04), p. 1752-1766
    Abstract: The current study evaluated the potential ameliorative effect of a dietary immune modulator, Nannochloropsis oculata microalga, on the mercuric chloride (HgCl 2 )-induced toxicity of Nile tilapia. Nile tilapia (45–50 g) were fed a control diet or exposed to ¼ LC 50 of HgCl 2 (0.3 mg/L) and fed on a medicated feed supplemented with N. oculata (5% and 10% (50 or 100 g/kg dry feed)) for 21 days. Growth and somatic indices, Hg 2+ bioaccumulation in muscles, and serum acetylcholinesterase (AChE) activity were investigated. Antioxidant and stress-related gene expression analyses were carried out in gills and intestines. Histopathological examinations of gills and intestines were performed to monitor the traits associated with Hg 2+ toxicity or refer to detoxification. Hg 2+ toxicity led to significant musculature bioaccumulation, inhibited AChE activity, downregulated genes related to antioxidants and stress, and elicited histopathological changes in the gills and intestine. Supplementation with N. oculata at 10% was able to upregulate the anti-oxidative-related genes while downregulated the stress apoptotic genes in gills and intestines compared to the unexposed group. In addition, minor to no histopathological traits were detected in the gills and intestines of the N. oculata -supplemented diets. Our data showed the benefit of dietary N. oculata in suppressing Hg 2+ toxicity, which might support its efficacy as therapeutic/preventive agent to overcome environmental heavy metal pollution in aquatic habitats.
    Type of Medium: Online Resource
    ISSN: 0163-4984 , 1559-0720
    URL: Article
    DOI: 10.1007/s12011-023-03771-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2072581-4
    SSG: 12
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