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  • 1
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    Efficacy and safety of abobotulinumtoxinA liquid formulation in cervical dystonia: A randomized‐controlled trial
    Wiley ; 2016
    In:  Movement Disorders Vol. 31, No. 11 ( 2016-11), p. 1649-1657
    Details
    In: Movement Disorders, Wiley, Vol. 31, No. 11 ( 2016-11), p. 1649-1657
    Abstract: Approved botulinum toxin A products require reconstitution. AbobotulinumtoxinA solution for injection is a ready‐to‐use liquid formulation of abobotulinumtoxinA. Objectives The objective of this study was to demonstrate the superior efficacy of abobotulinumtoxinA solution for injection to placebo and to test the noninferior efficacy of abobotulinumtoxinA solution for injection versus abobotulinumtoxinA (dry formulation) in cervical dystonia. Methods This was a phase‐3, multicenter, prospective, double‐blind, randomized, active, and placebo‐controlled study (N = 369). Patients with cervical dystonia were randomized (3:3:1) to abobotulinumtoxinA solution for injection 500 U, abobotulinumtoxinA 500 U, or placebo. Following the double‐blind phase, patients received abobotulinumtoxinA solution for injection, open‐label, for up to 4 cycles. The primary outcome was change from baseline at week 4 of the Toronto Western Spasmodic Torticollis Rating Scale total score. Secondary measures included change from baseline or cycle baseline in Toronto Western Spasmodic Torticollis Rating Scale scores. Results At week 4, both products were superior to placebo (Toronto Western Spasmodic Torticollis Rating Scale total score least square mean decrease from baseline, abobotulinumtoxinA solution for injection 500 U −12.5, abobotulinumtoxinA 500 U −14.0, placebo −3.9; P   〈  .0001 vs placebo). The noninferiority limit of 3 points in the Toronto Western Spasmodic Torticollis Rating Scale total score at week 4 was not met for abobotulinumtoxinA solution for injection versus abobotulinumtoxinA. Toronto Western Spasmodic Torticollis Rating Scale total score reductions were maintained for up to 4 cycles of abobotulinumtoxinA solution for injection open‐label follow‐up treatment. Safety profiles of abobotulinumtoxinA solution for injection and abobotulinumtoxinA were similar, with dysphagia and injection‐site pain the most frequent drug‐related adverse events. Conclusions Although the predefined noninferiority criterion was not met, abobotulinumtoxinA solution for injection was similarly effective to freeze‐dried abobotulinumtoxinA in reducing Toronto Western Spasmodic Torticollis Rating Scale total scores with a similar safety profile. AbobotulinumtoxinA solution for injection efficacy was maintained with chronic open‐label treatment, and this novel formulation may add convenience as well as dosing accuracy to treatment with abobotulinumtoxinA. © 2016 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v31.11
    DOI: 10.1002/mds.26760
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2041249-6
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  • 2
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    Mitochondrial genomes from Bronze Age Poland reveal genetic continuity from the Late Neolithic and additional genetic affinities with the steppe populations
    Wiley ; 2020
    In:  American Journal of Physical Anthropology Vol. 172, No. 2 ( 2020-06), p. 176-188
    Details
    In: American Journal of Physical Anthropology, Wiley, Vol. 172, No. 2 ( 2020-06), p. 176-188
    Abstract: In this work we aim to investigate the origins and genetic affinities of Bronze Age populations (2,400–1,100 BC) from the region of southern Poland and to trace maternal kinship patterns present in the burials of those populations by the use of complete mitochondrial genomes. Materials and methods We performed ancient DNA analyses for Bronze Age individuals from present‐day Poland associated with the Strzyżow culture, the Mierzanowice culture, and the Trzciniec Cultural circle. To obtain complete mitochondrial genomes, we sequenced genomic libraries using Illumina platform. Additionally, hybridization capture was used to enrich some of the samples for mitochondrial DNA. AMS 14 C‐dating was conducted for 51 individuals to verify chronological and cultural attribution of the analyzed samples. Results Complete ancient mitochondrial genomes were generated for 80 of the Bronze Age individuals from present‐day Poland. The results of the population genetic analyses indicate close maternal genetic affinity between Mierzanowice, Trzciniec, and Corded Ware culture‐associated populations. This is in contrast to the genetically more distant Strzyżów people that displayed closer maternal genetic relation to steppe populations associated with the preceding Yamnaya culture and Catacomb culture, and with later Scythians. Potential maternal kinship relations were identified in burials of Mierzanowice and Trzciniec populations analyzed in this study. Discussion Results revealed genetic continuity from the Late Neolithic Corded Ware groups to Bronze Age Mierzanowice and Trzciniec‐associated populations, and possible additional genetic contribution from the steppe to the formation of the Strzyżów‐associated group at the end of 3rd millennium BC. Mitochondrial patterns indicated several pairs of potentially maternally related individuals mostly in Trzciniec‐associated group.
    Type of Medium: Online Resource
    ISSN: 0002-9483 , 1096-8644
    URL: Issue
    URL: Article
    DOI: 10.1002/ajpa.v172.2
    DOI: 10.1002/ajpa.24057
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1495833-8
    detail.hit.zdb_id: 3129801-1
    SSG: 12
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  • 3
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    Maternal genetic origin of the late and final Neolithic human populations from present‐day Poland
    Wiley ; 2021
    In:  American Journal of Physical Anthropology Vol. 176, No. 2 ( 2021-10), p. 223-236
    Details
    In: American Journal of Physical Anthropology, Wiley, Vol. 176, No. 2 ( 2021-10), p. 223-236
    Abstract: We aim to identify maternal genetic affinities between the Middle to Final Neolithic (3850–2300 BC) populations from present‐day Poland and possible genetic influences from the Pontic steppe. Materials and methods We conducted ancient DNA studies from populations associated with Złota, Globular Amphora, Funnel Beaker, and Corded Ware cultures (CWC). We sequenced genomic libraries on Illumina platform to generate 86 complete ancient mitochondrial genomes. Some of the samples were enriched for mitochondrial DNA using hybridization capture. Results The maternal genetic composition found in Złota‐associated individuals resembled that found in people associated with the Globular Amphora culture which indicates that both groups likely originated from the same maternal genetic background. Further, these two groups were closely related to the Funnel Beaker culture‐associated population. None of these groups shared a close affinity to CWC‐associated people. Haplogroup U4 was present only in the CWC group and absent in Złota group, Globular Amphora, and Funnel Beaker cultures. Discussion The prevalence of mitochondrial haplogroups of Neolithic farmer origin identified in Early, Middle and Late Neolithic populations suggests a genetic continuity of these maternal lineages in the studied area. Although overlapping in time – and to some extent – in cultural expressions, none of the studied groups (Złota, Globular Amphora, Funnel Beaker), shared a close genetic affinity to CWC‐associated people, indicating a larger extent of cultural influence from the Pontic steppe than genetic exchange. The higher frequency of haplogroup U5b found in populations associated with Funnel Beaker, Globular Amphora, and Złota cultures suggest a gradual maternal genetic influx from Mesolithic hunter‐gatherers. Moreover, presence of haplogroup U4 in Corded Ware groups is most likely associated with the migrations from the Pontic steppe at the end of the Neolithic and supports the observed genetic distances.
    Type of Medium: Online Resource
    ISSN: 0002-9483 , 1096-8644
    URL: Issue
    URL: Article
    DOI: 10.1002/ajpa.v176.2
    DOI: 10.1002/ajpa.24372
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1495833-8
    detail.hit.zdb_id: 3129801-1
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  • 4
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    Allele frequencies of the new European Standard Set (ESS) loci in the population of Czech Republic
    Elsevier BV ; 2011
    In:  Forensic Science International: Genetics Supplement Series Vol. 3, No. 1 ( 2011-12), p. e395-e396
    Details
    In: Forensic Science International: Genetics Supplement Series, Elsevier BV, Vol. 3, No. 1 ( 2011-12), p. e395-e396
    Type of Medium: Online Resource
    ISSN: 1875-1768
    URL: Article
    DOI: 10.1016/j.fsigss.2011.09.059
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 2459032-0
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  • 5
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    Comparison of Y-chromosomal haplogroup predictors
    Elsevier BV ; 2017
    In:  Forensic Science International: Genetics Supplement Series Vol. 6 ( 2017-12), p. e145-e147
    Details
    In: Forensic Science International: Genetics Supplement Series, Elsevier BV, Vol. 6 ( 2017-12), p. e145-e147
    Type of Medium: Online Resource
    ISSN: 1875-1768
    URL: Article
    DOI: 10.1016/j.fsigss.2017.09.025
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2459032-0
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  • 6
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    Rare Case of a Localized Radial Nerve Amyloid Neuropathy
    Ovid Technologies (Wolters Kluwer Health) ; 2014
    In:  Journal of Clinical Neuromuscular Disease Vol. 16, No. 1 ( 2014-09), p. 20-23
    Details
    In: Journal of Clinical Neuromuscular Disease, Ovid Technologies (Wolters Kluwer Health), Vol. 16, No. 1 ( 2014-09), p. 20-23
    Type of Medium: Online Resource
    ISSN: 1522-0443
    URL: Article
    DOI: 10.1097/CND.0000000000000050
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2014
    detail.hit.zdb_id: 2060540-7
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  • 7
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    Encephalitis with Prolonged but Reversible Splenial Lesion
    Charles University in Prague, Karolinum Press ; 2015
    In:  Acta Medica (Hradec Kralove, Czech Republic) Vol. 58, No. 3 ( 2015), p. 108-112
    Details
    In: Acta Medica (Hradec Kralove, Czech Republic), Charles University in Prague, Karolinum Press, Vol. 58, No. 3 ( 2015), p. 108-112
    Abstract: Introduction: The splenium of the corpus callosum has a specific structure of blood supply with a tendency towards blood-brain barrier breakdown, intramyelinic edema, and damage due to hypoxia or toxins. Signs and symptoms of reversible syndrome of the splenium of the corpus callosum typically include disorientation, confusion, impaired consciousness, and epileptic seizures. Case report: A previously healthy 32-year-old man suffered from weakness, headache, and fever. Subsequently, he developed apathy, ataxia, and inability to walk, and therefore was admitted to the hospital. Cerebrospinal fluid showed protein elevation (0.9 g/l) and pleocytosis (232/1 ul). A brain MRI showed hyperintense lesions in the middle of the corpus callosum. The patient was treated with antibiotics, and subsequently, in combination with steroids. Two months later, the hyperintense lesions in the splenium and the basal ganglia had disappeared. Almost seven months since his hospitalization in the Department of Neurology, the patient has returned to his previous employment. He now does not exhibit any mental changes, an optic edema and urological problems have improved. In addition, he is now actively engaged in sports. Conclusion: We have described a case of a 32-year-old man with confusion, ataxia, and inability to stand and walk. The man developed a febrile meningeal syndrome and a hyperintense lesion of the splenium, which lasted for two months. Neurological changes, optic nerve edema, and urinary retention have resolved over the course of seven months. We think that the prolonged but transient lesion of the splenium may have been caused by encephalitis of viral origin.
    Type of Medium: Online Resource
    ISSN: 1211-4286 , 1805-9694
    URL: Article
    DOI: 10.14712/18059694.2015.103
    Language: English
    Publisher: Charles University in Prague, Karolinum Press
    Publication Date: 2015
    detail.hit.zdb_id: 2002210-4
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  • 8
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    The Potential Benefit of Intracarpal Pressure Measurement in Endoscopic Carpal Tunnel Syndrome Surgery – An Analysis of EMG Findings and Pressure Values
    Charles University in Prague, Karolinum Press ; 2009
    In:  Acta Medica (Hradec Kralove, Czech Republic) Vol. 52, No. 2 ( 2009), p. 63-68
    Details
    In: Acta Medica (Hradec Kralove, Czech Republic), Charles University in Prague, Karolinum Press, Vol. 52, No. 2 ( 2009), p. 63-68
    Abstract: Endoscopic carpal tunnel syndrome surgery is a modern minimally invasive method of carpal tunnel decompression. However, the method does also have its critics, who emphasize that there is an increased rate of complications in comparison to open procedures. To further improve and optimize results of endoscopic surgery we used an intracarpal pressure sensor to verify the effect of carpal tunnel decompression. The endoscopic single portal approach was used in all cases. Median nerve conduction studies were performed prior to and 3 months after surgery. Two groups, those with pressure studies and those without, were then compared according to several EMG parameters such as: median nerve distal motor latency, amplitude of motor response, sensory nerve conduction velocity to the index finger, and amplitude of sensory nerve action potential. In both groups, we observed similarly significant improvements in all conduction parameters, except the amplitude of motor response, which did not change in either group, i.e. no difference in postoperative EMG between the two groups was observed. Despite this fact, intracarpal pressure measurement is still useful in localising the point in which the median nerve is compressed and provides valuable functional information on the level decompression achieved.
    Type of Medium: Online Resource
    ISSN: 1211-4286 , 1805-9694
    URL: Article
    DOI: 10.14712/18059694.2016.106
    Language: English
    Publisher: Charles University in Prague, Karolinum Press
    Publication Date: 2009
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  • 9
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    The Changes of Peripheral Nerve Microstructure After Surgical Manipulation – Experiment on Rat Model
    Charles University in Prague, Karolinum Press ; 2005
    In:  Acta Medica (Hradec Kralove, Czech Republic) Vol. 48, No. 3-4 ( 2005), p. 165-172
    Details
    In: Acta Medica (Hradec Kralove, Czech Republic), Charles University in Prague, Karolinum Press, Vol. 48, No. 3-4 ( 2005), p. 165-172
    Abstract: The aim of our study was to describe histopathology of the peripheral nerve after its circular release followed by embedding in different environs. We operated on 18 male rats divided into 3 groups. In the first group right femoral nerve was surgically released. In the second group the nerve was enveloped by the subcutaneous fat flap. In the third one the nerve was wrapped up by the skeletal muscle. Six weeks later the animals were killed by exsanguination. The femoral nerve, in the first group, did not show any pathological changes. In the second group 3 animals appeared normal or nearly normal, nevertheless in 3 of them perineural fibrosis and axonal degeneration were observed. Histological reaction in the third group disclosed dispersed axonal injury. Our experiments using rat model imitate situation in humans. The results obtained will help us in making meaningful decision when performing peripheral nerve injury.
    Type of Medium: Online Resource
    ISSN: 1211-4286 , 1805-9694
    URL: Article
    DOI: 10.14712/18059694.2018.47
    Language: English
    Publisher: Charles University in Prague, Karolinum Press
    Publication Date: 2005
    detail.hit.zdb_id: 2002210-4
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  • 10
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    Myelin Oligodendrocyte Glycoprotein Antibody Associated Transverse Myelitis
    Charles University in Prague, Karolinum Press ; 2019
    In:  Acta Medica (Hradec Kralove, Czech Republic) Vol. 62, No. 3 ( 2019), p. 123-126
    Details
    In: Acta Medica (Hradec Kralove, Czech Republic), Charles University in Prague, Karolinum Press, Vol. 62, No. 3 ( 2019), p. 123-126
    Abstract: Antibodies against myelin oligodendrocyte glycoprotein cause inflammatory lesions of central myelin – in optic nerves, of the brainstem, and spinal cord. There are characteristic changes of CNS white matter, protein-cytological association in cerebrospinal fluid, MOG IgG antibodies, a very important differential diagnosis and a relatively mild course.
    Type of Medium: Online Resource
    ISSN: 1211-4286 , 1805-9694
    URL: Article
    DOI: 10.14712/18059694.2019.136
    Language: English
    Publisher: Charles University in Prague, Karolinum Press
    Publication Date: 2019
    detail.hit.zdb_id: 2002210-4
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