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  • 1
    In: Implementation Science, Springer Science and Business Media LLC, Vol. 12, No. S1 ( 2017-4)
    Type of Medium: Online Resource
    ISSN: 1748-5908
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2225822-X
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  • 2
    In: Clinical Trials, SAGE Publications, Vol. 12, No. 6 ( 2015-12), p. 618-626
    Abstract: Diverse samples in clinical trials can make findings more generalizable. We sought to characterize the prevalence of clinical trials in the United States that required English fluency for participants to enroll in the trial. Methods: We randomly chose over 10,000 clinical trial protocols registered with ClinicalTrials.gov and examined the inclusion and exclusion criteria of the trials. We compared the relationship of clinical trial characteristics with English fluency inclusion requirements. We merged the ClinicalTrials.gov data with US Census and American Community Survey data to investigate the association of English-language restrictions with ZIP-code-level demographic characteristics of participating institutions. We used Chi-squared tests, t-tests, and logistic regression models for analyses. Results: English fluency requirements have been increasing over time, from 1.7% of trials having such requirements before 2000 to 9.0% after 2010 (p  〈  0.001 from Chi-squared test). Industry-sponsored trials had low rates of English fluency requirements (1.8%), while behavioral trials had high rates (28.4%). Trials opening in the Northeast of the United States had the highest regional English requirement rates (10.7%), while trials opening in more than one region had the lowest (3.3%, p  〈  0.001). Since 1995, trials opening in ZIP codes with larger Hispanic populations were less likely to have English fluency requirements (odds ratio = 0.92 for each 10% increase in proportion of Hispanics, 95% confidence interval = 0.86–0.98, p = 0.013). Trials opening in ZIP codes with more residents self-identifying as Black/African American (odds ratio = 1.87, 95% confidence interval = 1.36–2.58, p  〈  0.001 for restricted cubic spline term) or Asian (odds ratio = 1.16 for linear term, 95% confidence interval = 1.07–1.25, p  〈  0.001) were more likely to have English fluency requirements. ZIP codes with higher poverty rates had trials with more English-language restrictions (odds ratio = 1.06 for a 10% poverty rate increase, 95% confidence interval = 1.001–1.11, p = 0.045). There was a statistically significant interaction between year and intervention type, such that the increase in English fluency requirements was more common for some interventions than for others. Conclusion: The proportion of clinical trials registered with ClinicalTrials.gov that have English fluency requirements for study inclusion has been increasing over time. English-language restrictions are associated with a number of characteristics, including the demographic characteristics of communities in which the sponsoring institutions are located.
    Type of Medium: Online Resource
    ISSN: 1740-7745 , 1740-7753
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2159773-X
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  • 3
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 10 ( 2020-12-15)
    Abstract: Patients undergoing radiation treatment for head and neck cancer experience significant side-effects that can impact a wide range of daily activities. Patients often report receiving insufficient information during and after treatment, which could impede rehabilitation efforts; they may also encounter practical and logistical barriers to receipt of supportive care. Thus, we developed a web-based program, My Journey Ahead , to provide information and strategies for managing symptom-focused concerns, which may be easily accessed from the patient’s home. The purpose of this study was to evaluate patient acceptability and satisfaction with the My Journey Ahead program. In Phase 1, five patients with head and neck squamous cell carcinoma (HNSCC) reviewed the web-based program and provided initial feedback, which informed program modifications. In Phase 2, 55 patients were recruited to evaluate the program. Patient assessments were obtained prior to and after use of the web-based program, and included measures of psychological distress, self-efficacy in coping with cancer-related issues, and satisfaction with the website. Among the 55 patients enrolled, 44 logged in and viewed the web-based program. Participants reported high levels of satisfaction with the information received, and indicated that the website was interesting and easy to use. Older age and higher levels of self-efficacy in coping were each associated with higher levels of satisfaction with the website. In summary, the web-based program was well-received by patients, the majority of whom found it to be informative and useful. An easy-to-use web-based program, particularly for older patients who may have difficulty locating reliable evidence-based information on the internet, may be helpful in addressing survivors’ needs in symptom management and coping with cancer. Clinical Trial Registration https://clinicaltrials.gov/ , NCT02442336
    Type of Medium: Online Resource
    ISSN: 2234-943X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2649216-7
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  • 4
    In: Oncotarget, Impact Journals, LLC, Vol. 6, No. 37 ( 2015-11-24), p. 39614-39633
    Type of Medium: Online Resource
    ISSN: 1949-2553
    URL: Issue
    Language: English
    Publisher: Impact Journals, LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2560162-3
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  • 5
    In: Breast Cancer Research, Springer Science and Business Media LLC, Vol. 14, No. 4 ( 2012-8)
    Type of Medium: Online Resource
    ISSN: 1465-542X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2041618-0
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  • 6
    Online Resource
    Online Resource
    Massachusetts Medical Society ; 2010
    In:  New England Journal of Medicine Vol. 362, No. 11 ( 2010-03-18), p. 1054-1055
    In: New England Journal of Medicine, Massachusetts Medical Society, Vol. 362, No. 11 ( 2010-03-18), p. 1054-1055
    Type of Medium: Online Resource
    ISSN: 0028-4793 , 1533-4406
    RVK:
    Language: English
    Publisher: Massachusetts Medical Society
    Publication Date: 2010
    detail.hit.zdb_id: 1468837-2
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  • 7
    In: JCO Precision Oncology, American Society of Clinical Oncology (ASCO), , No. 2 ( 2018-11), p. 1-24
    Abstract: Understanding the outcomes of returning individual genetic research results to participants is critical because some genetic variants are found to be associated with health outcomes and have become available for clinical testing. Materials and Methods BRCA1/2-negative women with early-onset breast cancer, multiple primary cancers, or a family history of breast cancer who participated in a gene discovery cancer registry were offered the opportunity to learn their individual genetic research results of 24 breast cancer susceptibility genes with a genetic counselor after predisclosure genetic counseling. Outcomes included uptake of research results, knowledge, informed choice, psychosocial adjustment, uncertainty, satisfaction, and uptake of clinical confirmation testing. Results Four hundred two potential participants were contacted. One hundred ninety-four participants (48%) did not respond despite multiple attempts, and 85 participants (21%) actively or passively declined. One hundred seven participants (27%) elected for predisclosure counseling and were more likely to be younger, married, and white. Ninety percent of participants who had predisclosure counseling elected to receive their genetic research results, and 89% made an informed choice. Knowledge increased significantly after predisclosure counseling, and anxiety, intrusive cancer-specific distress, uncertainty, and depression declined significantly after receipt of results. General anxiety and intrusive cancer-specific distress declined significantly for both participants with a positive result and those with a negative result. Sixty-four percent of participants had clinical confirmation testing when recommended, including all participants with a mutation in a high-penetrance gene. Conclusion Uptake of genetic research results may be lower than anticipated by hypothetical reports and small select studies. Participants who elected to receive research results with genetic providers did not experience increases in distress or uncertainty, but not all patients return for confirmation testing.
    Type of Medium: Online Resource
    ISSN: 2473-4284
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2018
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  • 8
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  American Journal of Clinical Oncology Vol. 39, No. 4 ( 2016-08), p. 321-326
    In: American Journal of Clinical Oncology, Ovid Technologies (Wolters Kluwer Health), Vol. 39, No. 4 ( 2016-08), p. 321-326
    Abstract: Randomized controlled trials (RCTs) are the most rigorous way of determining whether a cause-effect relation exists between treatment and outcome and for assessing the cost-effectiveness of a treatment. For many patients, cancer is a chronic illness; RCTs evaluating treatments for indolent cancers must evolve to facilitate medical decision-making, as “concrete” patient outcomes (eg, survival) will likely be excellent independent of the intervention, and detecting a difference between trial arms may be impossible. In this commentary, we articulate 9 recommendations that we hope future clinical trialists and funding agencies (including those under the National Cancer Institute) will take into consideration when planning RCTs to help guide subsequent interpretation of results and clinical decision making, based on RCTs of external beam radiation therapy dose escalation for the most common indolent cancer in men, that is, prostate cancer. We recommend routinely reporting: (1) race; (2) medical comorbidities; (3) psychiatric comorbidities; (4) insurance status; (5) education; (6) marital status; (7) income; (8) sexual orientation; and (9) facility-related characteristics (eg, number of centers involved, type of facilities, yearly hospital volumes). We discuss how these factors independently affect patient outcomes and toxicities; future clinicians and governing organizations should consider this information to plan RCTs accordingly (to maximize patient accrual and total n), select appropriate endpoints (eg, toxicity, quality of life, sexual function), actively monitor RCTs, and report results so as to identify the optimal treatment among subpopulations.
    Type of Medium: Online Resource
    ISSN: 0277-3732
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2043067-X
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  • 9
    In: American Journal of Clinical Oncology, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 4 ( 2021-04), p. 131-136
    Abstract: We sought to compare changes in patient-reported quality of life (PRQOL) following stereotactic body radiation therapy (SBRT), high dose rate (HDR), and low dose rate (LDR) brachytherapy for prostate cancer. Materials and Methods: International Prostate Symptom Score (IPSS), Sexual Health Inventory For Men (SHIM), and Expanded Prostate cancer Index Composite Short Form (EPIC-26) were prospectively collected for men with low/intermediate-risk cancer treated at a single institution. We used Generalized Estimating Equations to identify associations between variables and early (3 to 6 mo) or late (1 to 2 y) PRQOL scores. Minimally important differences (MID) were compared with assess clinical relevance. Results: A total of 342 LDR, 159 HDR, and 112 SBRT patients treated from 2001 to 2018 were eligible. Gleason score, PSA, and age were lower among LDR patients compared with HDR/SBRT. Unadjusted baseline IPSS score was similar among all groups. Adjusted IPSS worsened at all time points compared with baseline after LDR/HDR. At early/late time points, rates of IPSS MID after LDR were higher compared to HDR/SBRT. There were no IPSS differences between SBRT and HDR. All modalities showed early and late SHIM worsening. There were no temporal differences in SHIM between SBRT and brachytherapy. There were no differences in EPIC subdomains between HDR and SBRT. Bowel symptoms worsened early after SBRT, whereas urinary irritative/obstructive symptoms worsened late after HDR. Among all domains, MID after SBRT and HDR were similar. Conclusions: In a cohort of patients treated with modern radiotherapy techniques, HDR and SBRT resulted in clinically meaningful improved urinary PRQOL compared with LDR.
    Type of Medium: Online Resource
    ISSN: 0277-3732
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2043067-X
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  • 10
    Online Resource
    Online Resource
    American Association for Cancer Research (AACR) ; 2020
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 29, No. 6_Supplement_2 ( 2020-06-01), p. C022-C022
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 6_Supplement_2 ( 2020-06-01), p. C022-C022
    Abstract: Introduction: The current US Black population is heterogeneous, consisting of individuals of US ancestry (direct descendants of enslaved Africans in the US) and individuals of African and Caribbean ancestry (descendants or individuals who have voluntarily migrated to the US post-slavery). Our previous work has shown distinct differences between Black immigrants and US-born Blacks in cancer survival, and cancer fatalism. This study will assess the differences in cancer risk factors, risk behaviors and health-seeking patterns among the African diaspora living in Philadelphia County compared to that of their native countries. Methods: STEPs data Forty-eight countries were defined as Sub-Saharan Africa (SSA) and 29 islands/island groupings were defined as the Caribbean (CA). Sixteen variables of interest were selected including: percentage overweight, percentage who currently smoke tobacco daily, percentage of current drinkers, and average BMI. CAP3 data Recruitment activities took place throughout Philadelphia County beginning in 2012 and is ongoing. Subjects completed a detailed questionnaire assessing behavioral, nutritional, demographics and provided bio-specimens. Results: Data were available for 39 SSA countries and nine CA islands and were included in the analysis for this study. The CAP3 dataset has a high response rate and most variables of interest included the full study population. Mean BMI reported from the STEPS data was 22.8 (95% CI 19.6-26.1) and 27.1 (95% CI 26.6-27.5) kg/m2 for the SSA and the CA, respectively; BMI for African and Caribbean immigrants were 28.6 (95% CI 27.6-29.6) and 28.8 (95% CI 27.5-30.2), respectively, a considerable increase among African immigrants. Alcohol consumption was highest in the Caribbean (54% [95% CI 52.1-55.9] vs 26.5% [95% CI 25.4-27.8] ) and Caribbean immigrants in the CAP3 population (23.7% [95% CI 14.7-32.6] vs 16% [95% CI 10.6-21.4] ) when compared to SSA and African immigrants, respectively. A noticeable difference was also observed in the proportion of individuals that currently used tobacco. A higher proportion of individuals reported current daily tobacco use in SSA and the CA when compared to immigrants in the CAP3 dataset (SSA: 8.2% [95% CI: 6.2-10.3]; CA 12.2% [95% CI: 10.1-14.2] vs. African immigrant 0%; and Caribbean immigrants 4.6% (95% CI: 2.7-18.0). BMI, alcohol consumption and current daily tobacco use was highest among US-born blacks in the CAP3 dataset (30.6 [95% CI: 29.7-31.5]; 38.6% [95% CI: 33.4-43.3] ; and 14.1% [95% CI: 10.7-17.4]. Conclusion: The healthy immigrant affect has been well described in the literature and is apparent in our study population, where immigrants are healthier than native-born individuals. However, we also observed that immigrants were healthier than individuals in their native country, prompting the need for further investigation of this phenomena. Citation Format: Elizabeth L Blackman, Jenisha Stapleton, Brian L Egleston, Camille CR Ragin. Effect of migration to the US on health characteristics of the African diaspora [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr C022.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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