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  • 1
    Online Resource
    Online Resource
    National Medical Research Center for Childrens Health ; 2022
    In:  Russian Pediatric Journal Vol. 25, No. 5 ( 2022-10-30), p. 369-372
    In: Russian Pediatric Journal, National Medical Research Center for Childrens Health, Vol. 25, No. 5 ( 2022-10-30), p. 369-372
    Abstract: Introduction. In pediatric practice, one may encounter various volumetric formations of the stomach, both benign and malignant. The verification and localization of the neoplasma is the most difficult issue in everyday work. Most often, benign tumors are represented by a rounded submucosal formation, covered with an intact mucous membrane. The most common formations that can be found in a child are leiomyomas. Objective is to present the first experience of endoscopic submucosal dissection and enucleation of the choristoma in a child. Clinical observation. The girl was admitted for inpatient treatment with complaints of prolonged (2 years) abdominal syndrome and mass formation of the antrum of the stomach. According to CT data, a voluminous soft tissue formation 8 × 7 × 12 mm in size was revealed in the antrum of the stomach, which does not accumulate a contrast agent. When performing esophagogastroduodenoscopy and endosonography, a submucosal formation of the prepyloric stomach was visualized, with dimensions of 7 × 10 mm. The macroscopic picture of the tumor corresponded to gastric leiomyoma. However, given the clinical picture, it was impossible to exclude the chorous stomach. Thus, the diagnosis was formulated: volumetric formation of the stomach. Leiomyoma? Choristoma? In the course of further treatment, surgical treatment was performed, in the amount of submucosal enucleation of the formation. According to the morphological study, the remote formation corresponded to the ectopic pancreatic tissue. Conclusion. Choristoma does not always have a “classic” appearance with retraction in the center, and the clinical picture is of great importance in the verification of neoplasma. Endoscopic submucosal removal of gastric choristoma is a minimally invasive and effective method of surgical treatment that can be used in children.
    Type of Medium: Online Resource
    ISSN: 1560-9561
    URL: Issue
    Language: Unknown
    Publisher: National Medical Research Center for Childrens Health
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 13, No. 1 ( 2023-05-10), p. 73-82
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 13, No. 1 ( 2023-05-10), p. 73-82
    Abstract: BACKGROUND: Obstructive variants of chronic duodenal obstruction may be caused by congenital malformations, such as rare periampullary duodenal duplication cysts. This localization of gastrointestinal duplications is the rarest and is not described in the domestic literature. AIM: This study aimed to present the experience of the management of periampullary duodenal duplication cysts in children. CASES REPORT: Seven children with periampullary duodenal duplication cysts underwent surgery between 2007 and 2022. All patients suffered from prolonged abdominal pain, vomiting of food, and bile. Two children had recurrent pancreatitis, and one child underwent repeated operations for high intestinal obstruction and biliary obstruction in other hospitals. An abdominal cyst was suspected in one patient at another hospital, and the child underwent exploratory laparoscopy, but no formation was found. Ultrasound, gastroduodenoscopy, computed tomography, and magnetic resonance imaging were performed on these children. Ultrasound examination showed a peristaltic cystic formation up to 4 cm in diameter with a double wall. Gastroduodenoscopy showed formation in the second portion of the duodenum in the region of the major duodenal papilla. This formation covers the intestinal lumen by two-thirds and up to nearly complete obturation. The relationship between duodenal duplication and the bile and pancreatic ducts was clarified on magnetic resonance cholangiopancreatography: the relationship was suspected in two children. All patients underwent wide transduodenal excision of periampullary duodenal duplication cyst; in four cases, laparoscopic access was used. No intra- and postoperative complications occurred. Histological examination revealed true duplications in all cases. The children were discharged on days 1112. In the follow-up after 3 months and 10 years, no complications were noted. CONCLUSIONS: Periampullary duodenal duplication cysts can be a cause of chronic duodenal obstruction. Transduodenal excision of periampullary duodenal duplication cysts is the optimal treatment, and this operation can be performed laparoscopically.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 13, No. 2 ( 2023-07-15), p. 133-145
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 13, No. 2 ( 2023-07-15), p. 133-145
    Abstract: BACKGROUND: Surgical treatment of pancreatic cysts is one of the most difficult procedures in pediatric surgery. In children with pancreatic cysts, the issues of differential diagnosis and determining the connection of the cyst cavity with the main pancreatic duct remain problematic. Recent publications have focused on the use of endoscopic ultrasonography in pediatric practice to visualize the parenchyma and the ductal system of the pancreas with high accuracy. AIM: This work aimed to study the results of treatment of children with cystic formations of the pancreas using modern radiation diagnostic methods and minimally invasive surgical technologies. MATERIALS AND METHODS: Analysis was conducted on the results of treatment of 66 patients consisting of 30 boys (45.5%) and 36 girls (54.5%) aged 6 months to 18 years (average age of 10.9 5.2 years) with extraparenchymatous and intraparenchymatous pancreatic cysts. RESULTS: Multispiral computed tomography (Se 90%, Sp 91%, and Ac 91%; p 0.05) and magnetic resonance imaging (Se 96%, Sp 94%, Ac 95%; p 0.05) are the most informative for the differential diagnosis of intra- and extraparenchymatous pancreatic cysts. For thin-walled extraparenchymatous cysts up to 6 cm in size, conservative therapy is effective in the early period of the disease. External (42.4%) and internal (51.3%) drainage of cysts can be performed when the existence of pancreatic pseudocysts is prolonged (more than 2 months). Indications for simultaneous longitudinal pancreaticoejunostomy may occur in 9.5% of patients. Excision of the pseudocyst with pancreatic resection may be required in 4.7% of cases. For intraparenchymatous cysts, 33.3% of cases require the enucleation of cystic formation, 25% require the distal splenoserving resection of the pancreas, 25% require the central resection of the pancreas with the imposition of distal pancreatoejunoanastomosis, and 12.5% require pylori-preserving pancreatoduodenal resection. Approximately 70.8% of surgical interventions on the pancreas in children can be performed by laparoscopic access with a conversion rate in 12.5% of cases. CONCLUSIONS: The choice of surgical intervention in children with pancreatic cysts is determined by the etiology, cyst size, localization, connection with the main pancreatic duct, and degree of involvement of the parenchyma in the tumor process. Most operations on the pancreas may be performed using minimally invasive approaches.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 4
    In: Problems of Endocrinology, Endocrinology Research Centre, Vol. 65, No. 5 ( 2019-11-23), p. 319-329
    Abstract: BACKGROUND: Congenital hyperinsulinism (CHI) is a severe disease with a high risk of complications including neurological deficit. Persistent hypoglycemia in patients with focal form of CHI can not be managed with medical treatment in 96.4% of cases, what subsequently leads to surgical treatment. Currently, there is a lack of information regarding patients with focal form of CHI. This study is aimed at finding better approaches for diagnosis and treatment of patients with focal form of CHI. AIMS: To study clinical, genetic and PET/CT findings of the focal form of CHI in Russian group of patients. MATERIALS AND METHODS: The observational research included all patients with a histologically confirmed focal form of CHI, who were admitted to Endocrinology Research Centre during the period from January 2008 to January 2019. A statistical analysis of clinical data, genotype, and positron emission tomography (PET) with 18F-dihydroxyphenylalanine (18F-DOPA) was performed. The median follow-up was 18 months. RESULTS: The study included 31 patients with focal CHI (14 boys, 45.2%). All patients had a neonatal presentation of the disease and demanded high levels of continuous glucose infusion to maintain euglycemia. The difference between the age of hypoglycemia presentation and the age of diagnosis ranged from 1 day to 3.9 months. In all cases, diazoxide was found to be ineffective. However, in 9 patients, it was possible to withdraw continuous glucose infusion and maintain euglycemia using octreotide in the preoperative period. A molecular genetic study allowed us to detect diverse pathogenic variants in ABCC8 and KCNJ11 genes in 30 patients. According to PET data with 18F-DOPA, the pancreatic index (PI) varied widely from 1.16 to 3.59. After partial resection of the pancreatic region with insulin hypersecretion, all patients showed complete recovery. CONCLUSIONS: The focal form of CHI is a severe condition with high prevalence of neurological complications. For preoperative diagnosis of the morphological form of the disease, it is necessary to conduct genetic analysis and radionuclide studies. Solely evaluation of mathematical parameters in 18F-DOPA PET without taking into account the visual data and the results of genetic analysis does not allow establishing the robust diagnosis. Timely diagnosis, identification of risk factors, and prevention of complications of persistent hypoglycemia are important tasks for clinicians.
    Type of Medium: Online Resource
    ISSN: 2308-1430 , 0375-9660
    URL: Issue
    Language: Unknown
    Publisher: Endocrinology Research Centre
    Publication Date: 2019
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  • 5
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2020
    In:  Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care Vol. 10, No. 1 ( 2020-11-21), p. 35-42
    In: Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care, ECO-Vector LLC, Vol. 10, No. 1 ( 2020-11-21), p. 35-42
    Abstract: Introduction. Gastric duplication cyst is a rare clinical observation. More often, these cysts are localized in the fundus or body of the stomach and have a common muscle layers and blood supply. Even more rarely, duplication cysts are not anatomically connected to the stomach and are located in other parts of the abdominal cavity or in the retroperitoneal space. Cystic duplication of the gastrointestinal tract, which are localized in the pancreas, is extremely rare. The aim of the study is to demonstrate the possibility of using laparoscopy for this disease. Materials and methods. The paper describes three rare clinical observations of gastric duplication cyst topographically associated with the pancreas. In the first clinical observation, gastric duplication cyst was combined with mediastinal duplication cysts, an esophageal bronchial fistula, and extralobar pulmonary sequestrations. In the second observation, a duplication cyst had communication with the pancreatic duct system and was clinically manifested by recurrent bleeding. In the third case, a duplication cyst is diagnosed behind the body and tail of the pancreas. Results. In all cases, surgical treatment was carried out by the laparoscopic method, leading to complete recovery. Histological examination in all the described observations confirmed the gastric type of epithelium of the mucous membrane of the cysts. The article provides a review of the literature. Conclusion. Thus, the efficiency of laparoscopic interventions in children with gastric duplications topographically associated with the pancreas was demonstrated. The described rare clinical manifestations, a combination of defects, as well as the possible presence of heterotopy of the mucous membrane of the duplication cyst confirm the need for surgical correction of the disease.
    Type of Medium: Online Resource
    ISSN: 2587-6554 , 2219-4061
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2020
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  • 6
    Online Resource
    Online Resource
    Union of the Medical Community "National Medical Chamber" ; 2019
    In:  Russian Journal of Pediatric Surgery Vol. 23, No. 1 ( 2019-04-04), p. 38-39
    In: Russian Journal of Pediatric Surgery, Union of the Medical Community "National Medical Chamber", Vol. 23, No. 1 ( 2019-04-04), p. 38-39
    Abstract: The article presents a clinical case of a traumatic complete rupture of the pancreas at the level of the isthmus in a 6-year-old child. Twelve hours after the injury, laparoscopy, laparotomy, a pancreas rupture at the level of the isthmus was performed. Surgical treatment consisted in stenting the main pancreatic duct with a catheter, carrying the latter through a large duodenal nipple, sealing the parenchyma of the gland, and draining the gland bag. In the early postoperative period, no complications were noted. The stent is removed 5 weeks after the operation. The catamnesis was followed for about a year, complications were not observed.
    Type of Medium: Online Resource
    ISSN: 2412-0677 , 1560-9510
    URL: Issue
    Language: Unknown
    Publisher: Union of the Medical Community "National Medical Chamber"
    Publication Date: 2019
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