In:
Journal of Pharmacy and Pharmacology, Oxford University Press (OUP), Vol. 15, No. 1 ( 2011-04-12), p. 671-677
Abstract:
Plasma concentrations of pralidoxime methane sulphonate (P2S) have been determined in man after self-administration by an automatic injector. After administration of 10 mg./kg. P2S in a 50 per cent w/v solution, concentrations over 4 μg./ml. were reached within 6 min. and maintained for about 90 min. After 20 mg./kg., plasma concentrations over 4 μg./ml. were maintained for about 170 min. Except for pain at the site of injection, which disappeared after a few hr., no serious side reactions could be detected. The drug can be stored for 5 years at 5° with less than 7 per cent decomposition. The decomposition products were found to be less toxic than the unchanged oxime. N-Methylpyridinium-2-carboxamide was identified as a major degradation product.
Type of Medium:
Online Resource
ISSN:
2042-7158
,
0022-3573
DOI:
10.1111/j.2042-7158.1963.tb12859.x
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2011
detail.hit.zdb_id:
2041988-0
detail.hit.zdb_id:
2050532-2
SSG:
15,3
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