In:
Canadian Journal of Physics, Canadian Science Publishing, Vol. 96, No. 7 ( 2018-07), p. 693-699
Abstract:
Saturation transfer difference nuclear magnetic resonance is a ligand-based screening technique that focuses directly on the physical interaction of a macromolecule (protein, enzyme, etc.) and a small ligand. It is a powerful tool in pharmaceutical research. Here, a comparison is reported of the binding characteristics of ibuprofen and a novel anti-inflammatory agent to cyclooxygenase-1 and cyclooxygenase-2 enzymes as an application of saturation transfer difference nuclear magnetic resonance. It has been shown that this novel agent is capable of binding to both isoforms of the cyclooxygenase enzymes. It has also been reported that novel agent binds better to cyclooxygenase-2.
Type of Medium:
Online Resource
ISSN:
0008-4204
,
1208-6045
DOI:
10.1139/cjp-2017-0759
Language:
English
Publisher:
Canadian Science Publishing
Publication Date:
2018
detail.hit.zdb_id:
2021497-2
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