In:
Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-10-1)
Abstract:
Zebrafish have been found to be a premier model organism in biological and regeneration research. However, the comprehensive cell compositions and molecular dynamics during tissue regeneration in zebrafish remain poorly understood. Here, we utilized Microwell-seq to analyze more than 250,000 single cells covering major zebrafish cell types and constructed a systematic zebrafish cell landscape. We revealed single-cell compositions for 18 zebrafish tissue types covering both embryo and adult stages. Single-cell mapping of caudal fin regeneration revealed a unique characteristic of blastema population and key genetic regulation involved in zebrafish tissue repair. Overall, our single-cell datasets demonstrate the utility of zebrafish cell landscape resources in various fields of biological research.
Type of Medium:
Online Resource
ISSN:
2296-634X
DOI:
10.3389/fcell.2021.743421
DOI:
10.3389/fcell.2021.743421.s001
DOI:
10.3389/fcell.2021.743421.s002
DOI:
10.3389/fcell.2021.743421.s003
DOI:
10.3389/fcell.2021.743421.s004
DOI:
10.3389/fcell.2021.743421.s005
DOI:
10.3389/fcell.2021.743421.s006
DOI:
10.3389/fcell.2021.743421.s007
DOI:
10.3389/fcell.2021.743421.s008
DOI:
10.3389/fcell.2021.743421.s009
DOI:
10.3389/fcell.2021.743421.s010
DOI:
10.3389/fcell.2021.743421.s011
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2737824-X
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