GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    NR3C2 genotype is associated with response to spironolactone in diastolic heart failure patients from the Aldo‐DHF trial
    Wiley ; 2021
    In:  Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy Vol. 41, No. 12 ( 2021-12), p. 978-987
    Details
    In: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Wiley, Vol. 41, No. 12 ( 2021-12), p. 978-987
    Abstract: This study aimed to determine if variants in NR3C2 , which codes the target protein of spironolactone, or CYP11B2 , which is involved in aldosterone synthesis, were associated with spironolactone response, focused on the primary end point of diastolic function (E/e′), in Aldosterone Receptor Blockade in Diastolic Heart Failure (Aldo‐DHF) participants. Design Post‐hoc genetic analysis. Data Source Data and samples were derived from the multi‐center, randomized, double‐blind, placebo‐controlled Aldo‐DHF trial. Patients Aldo‐DHF participants treated with spironolactone ( n  = 184) or placebo ( n  = 178) were included. Intervention Participants were genotyped for NR3C2 rs5522, NR3C2 rs2070951 and CYP11B2 rs1799998 via pyrosequencing. Measurements In the placebo and spironolactone arms, separate multivariable linear regression analyses were performed for change in E/e′ with each single nucleotide polymorphism (SNP), adjusted for age, sex, and baseline E/e′. To discern potential mechanisms of a genotype effect, associated SNPs were further examined for their association with change in blood pressure, circulating procollagen type III N‐terminal peptide (PIIINP), and left atrial area. Main Results Carriers of the rs5522 G allele in the placebo arm had a greater increase in E/e′ over the 12‐month course of the trial compared to noncarriers (β = 1.10; 95% confidence interval [CI]: 0.05–2.16; p  = 0.04). No corresponding E/e′ worsening by rs5522 genotype was observed in the spironolactone arm. None of the other genotypes were associated with change in E/e′. Compared to noncarriers, rs5522 G carriers also had a greater increase in left atrial area with placebo (β = 0.83; 95% CI: 0.17–1.48; p  = 0.01) and a greater reduction in diastolic blood pressure with spironolactone (β = −3.56; 95% CI: −6.73 to −0.39; p  = 0.03). Serum PIIINP levels were similar across rs5522 genotypes. Conclusions Our results suggest that spironolactone attenuates progression of diastolic dysfunction associated with the NR3C2 rs5522 G allele. Validation of our findings is needed.
    Type of Medium: Online Resource
    ISSN: 0277-0008 , 1875-9114
    URL: Issue
    URL: Article
    DOI: 10.1002/phar.v41.12
    DOI: 10.1002/phar.2626
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2061167-5
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Abnormal Menstrual Bleeding
    Decker Medicine ; 2020
    In:  DeckerMed Obstetrics and Gynecology ( 2020-11-13)
    Details
    In: DeckerMed Obstetrics and Gynecology, Decker Medicine, ( 2020-11-13)
    Abstract: Abnormal uterine bleeding (AUB) is a common presentation that can occur in all age groups. AUB is an umbrella term for any uterine bleeding that occurs outside a woman’s normal pattern in volume, regularity, and/or timing. AUB is described by using frequency, regularity, duration, and volume or by using PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy and premalignant conditions; Coagulopathy, Ovulatory dysfunction, Endometrial, Iatrogenic, Not yet classified). Workup for AUB comprises a history (with a detailed menstrual history), physical examination (including a pelvic and bimanual examination), lab tests, and imaging (primarily transvaginal ultrasonography). For treatment, medical therapies should be considered before surgical therapies, especially when fertility is desired. The decisions for treatment are based on etiology, fertility concerns, contraindications, or patient preference. Of the medical therapies, there are hormonal and nonhormonal therapies. The most common treatments for AUB are levonorgestrel intrauterine device, tranexamic acid, oral contraceptives, and nonsteroidal anti-inflammatory drugs. The most common surgical treatments are myomectomy, endometrial ablation, uterine artery embolization, and hysterectomy. This review contains 7 figures, 11 tables and 49 references Key words: abnormal uterine bleeding, adenomyosis, contraceptives, endometrial, fibroids, hysterectomy, menorrhagia
    Type of Medium: Online Resource
    URL: Journal
    URL: Article
    DOI: 10.2310/OBG
    DOI: 10.2310/OBG.19011
    Language: Unknown
    Publisher: Decker Medicine
    Publication Date: 2020
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Obesity and STING1 genotype associate with 23-valent pneumococcal vaccination efficacy
    American Society for Clinical Investigation ; 2020
    In:  JCI Insight Vol. 5, No. 9 ( 2020-5-7)
    Details
    In: JCI Insight, American Society for Clinical Investigation, Vol. 5, No. 9 ( 2020-5-7)
    Type of Medium: Online Resource
    ISSN: 2379-3708
    URL: Article
    URL: Article
    DOI: 10.1172/jci.insight.136141
    DOI: 10.1172/jci.insight.136141DS1
    Language: English
    Publisher: American Society for Clinical Investigation
    Publication Date: 2020
    detail.hit.zdb_id: 2874757-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Identification of a SGCD × Discrimination Interaction Effect on Systolic Blood Pressure in African American Adults in the Jackson Heart Study
    Oxford University Press (OUP) ; 2022
    In:  American Journal of Hypertension Vol. 35, No. 11 ( 2022-11-02), p. 938-947
    Details
    In: American Journal of Hypertension, Oxford University Press (OUP), Vol. 35, No. 11 ( 2022-11-02), p. 938-947
    Abstract: In the United States, hypertension disproportionately afflicts over half of African American adults, many of whom also experience racial discrimination. Understanding gene × discrimination effects may help explain racial disparities in hypertension. METHODS We tested for the main effects and interactive effects of 5 candidate single nucleotide polymorphisms (SNPs: rs2116737, rs11190458, rs2445762, rs2597955, and rs2416545) and experiences of discrimination on blood pressure (BP) in African Americans not taking antihypertensive medications in the Jackson Heart Study from Mississippi (n = 2,933). Multiple linear regression models assumed an additive genetic model and adjusted for ancestry, age, sex, body mass index, education, and relatedness. We additionally tested recessive and dominant genetic models. RESULTS Discrimination was significantly associated with higher diastolic BP (P = 0.003). In contrast, there were no main effects of any SNP on BP. When analyzing SNPs and discrimination together, SGCD (Sarcoglycan Delta; rs2116737) demonstrated a gene × environment interaction. Specifically, an SGCD × Discrimination interaction was associated with systolic BP (β =1.95, P = 0.00028) in a recessive model. Participants carrying a T allele, regardless of discrimination experiences, and participants with a GG genotype and high experiences of discrimination had higher systolic BP than participants with a GG genotype and low experiences of discrimination. This finding suggests the SGCD GG genotype may have a protective effect on systolic BP, but only in a setting of low discrimination. CONCLUSIONS The inclusion of culturally relevant stressors, like discrimination, may be important to understand the gene-environment interplay likely underlying complex diseases with racial health inequities.
    Type of Medium: Online Resource
    ISSN: 0895-7061 , 1941-7225
    URL: Article
    DOI: 10.1093/ajh/hpac098
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1479505-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    3563 Clinical research training methods that improve self-efficacy in clinical research domains
    Cambridge University Press (CUP) ; 2019
    In:  Journal of Clinical and Translational Science Vol. 3, No. s1 ( 2019-03), p. 64-64
    Details
    In: Journal of Clinical and Translational Science, Cambridge University Press (CUP), Vol. 3, No. s1 ( 2019-03), p. 64-64
    Abstract: OBJECTIVES/SPECIFIC AIMS: The study aims to determine the current clinical research training interventions of MD-PhD programs and how effective they are in promoting clinical research self-efficacy. METHODS/STUDY POPULATION: A national survey of MD-PhD trainees was conducted in 2018 to identify clinical research training methods and self-efficacy for clinical research skills. MD-PhD program directors and coordinators from 108 institutions were asked to distribute the survey to their students. Responses were received from 61 institutions (56.5%). Responses were obtained from 647 MD-PhD students in all years of training, representing 17.9% of the 3613 possible participants at the 61 medical schools represented. No compensation was provided for this study. RESULTS/ANTICIPATED RESULTS: The primary methods of clinical research training reported by students included didactics, mentored clinical research, didactics plus mentored clinical research, didactics plus clinical research practicum, and didactics plus mentored clinical research plus clinical research practicum. A quarter of all participants reported having no clinical research training. Clinical research self-efficacy was then correlated with the amount of clinical research training. Students exposed to no clinical research had the lowest self-efficacy in clinical research skills and students experiencing didactics plus mentored clinical research plus clinical research practicum had the highest perceived self-efficacy in clinical research domains. DISCUSSION/SIGNIFICANCE OF IMPACT: This is one of the first studies assessing clinical research training methods for MD-PhD students and assessing their efficacy. We found that of all students questioned, 25% mentioned had not received any type of clinical research training. The remaining students identified 5 research training methods that institutions currently use. This work highlights the importance of clinical research experience students need to improve their self-efficacy, a major influence on research career outcomes.
    Type of Medium: Online Resource
    ISSN: 2059-8661
    URL: Article
    DOI: 10.1017/cts.2019.151
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2898186-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    β1‐receptor polymorphisms and junctional ectopic tachycardia in children after cardiac surgery
    Wiley ; 2022
    In:  Clinical and Translational Science Vol. 15, No. 3 ( 2022-03), p. 619-625
    Details
    In: Clinical and Translational Science, Wiley, Vol. 15, No. 3 ( 2022-03), p. 619-625
    Abstract: Junctional ectopic tachycardia (JET) is a potentially life‐threatening postoperative arrhythmia in children with specific congenital heart defects and can contribute significantly to postoperative morbidity for at‐risk populations. In adults, β1‐adrenergic receptor ( ADRB1 ) and β2‐adrenergic receptor ( ADRB2 ) genotypes have been associated with increased risk for arrhythmias. However, their association with arrhythmia risk in children is unknown. We aimed to test associations between ADRB1 and ADRB2 genotypes and postoperative JET in patients with congenital heart defects. Children who underwent cardiac surgery were genotyped for the ADRB1 p.Ser49Gly (rs1801252; c.145A 〉 G), p.Arg389Gly (rs1801253; c.1165C 〉 G), ADRB2 p.Arg16Gly (rs1042713; c.46A 〉 G), and p.Glu27Gln (rs1042714; c.79G 〉 C) polymorphisms. The occurrence of postoperative JET was assessed via cardiologist‐interpreted electrocardiograms. Genotype associations with JET were analyzed via logistic regression, adjusted for clinical variables associated with JET, with separate analysis in patients not on a β‐blocker. Of the 343 children included (median age 8 months, 53% boys, 69% European ancestry), 45 (13%) developed JET. The Arg389Arg genotype was not significantly associated with JET in the overall population (odds ratio [OR] = 1.96, 95% confidence interval [CI]  = 0.96–4.03, p  = 0.064), but was nominally associated in patients not taking a β‐blocker ( n  = 324, OR = 2.25, 95% CI = 1.05–4.80. p  = 0.034). None of the other variants were associated with JET. These data suggest that the ADRB1 Arg389Arg genotype may predict risk for JET following cardiac surgery in pediatric patients in the absence of β‐blockade. Whether treatment with a β‐blocker ameliorates this association requires further research.
    Type of Medium: Online Resource
    ISSN: 1752-8054 , 1752-8062
    URL: Issue
    URL: Article
    DOI: 10.1111/cts.v15.3
    DOI: 10.1111/cts.13178
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2433157-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Genetic polymorphisms in ADRB2 and ADRB1 are associated with differential survival in heart failure patients taking β-blockers
    Springer Science and Business Media LLC ; 2022
    In:  The Pharmacogenomics Journal Vol. 22, No. 1 ( 2022-02), p. 62-68
    Details
    In: The Pharmacogenomics Journal, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-02), p. 62-68
    Type of Medium: Online Resource
    ISSN: 1470-269X , 1473-1150
    URL: Article
    DOI: 10.1038/s41397-021-00257-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2051501-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Journal of the American Heart Association Vol. 7, No. 6 ( 2018-03-20)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 6 ( 2018-03-20)
    Abstract: Thiazide and thiazide‐like diuretics are first‐line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide‐like diuretic/chlorthalidone‐induced glucose change. Methods and Results Genome‐wide analysis of glucose change after treatment with chlorthalidone was performed by race among the white (n=175) and black (n=135) participants from the PEAR ‐2 (Pharmacogenomic Evaluation of Antihypertensive Responses‐2). Single‐nucleotide polymorphisms with P 〈 5×10 −8 were further prioritized using in silico analysis based on their expression quantitative trait loci function. Among blacks, an intronic single‐nucleotide polymorphism (rs9943291) in the HMGCS 2 was associated with increase in glucose levels following chlorthalidone treatment (ß=12.5; P =4.17×10 −8 ). G‐allele carriers of HMGCS 2 had higher glucose levels (glucose change=+16.29 mg/dL) post chlorthalidone treatment compared with noncarriers of G allele (glucose change=+2.80 mg/dL). This association was successfully replicated in an independent replication cohort of hydrochlorothiazide‐treated participants from the PEAR study (ß=5.54; P =0.023). A meta‐analysis of the 2 studies was performed by race in Meta‐Analysis Helper, where this single‐nucleotide polymorphism, rs9943291, was genome‐wide significant with a meta‐analysis P value of 3.71×10 −8 . HMGCS 2 , a part of the HMG ‐CoA synthase family, is important for ketogenesis and cholesterol synthesis pathways that are essential in glucose homeostasis. Conclusions These results suggest that HMGCS 2 is a promising candidate gene involved in chlorthalidone and Hydrochlorothiazide (HCTZ)‐induced glucose change. This may provide insights into the mechanisms involved in thiazide‐induced hyperglycemia that may ultimately facilitate personalized approaches to antihypertensive selection for hypertension treatment. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifiers: NCT 00246519 and NCT 01203852.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.117.007339
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2653953-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Abstract P348: Validation of SGCD (rs2116737) Genotype-Discrimination Interaction as a Determinant of Blood Pressure Variation in the Jackson Heart Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Circulation Vol. 139, No. Suppl_1 ( 2019-03-05)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 139, No. Suppl_1 ( 2019-03-05)
    Abstract: Introduction: Previous anthropological studies have demonstrated the utility of integrating genetic and psychosocial data, such as discrimination, to understand complex phenotypes such as blood pressure (BP). In these studies, including both single nucleotide polymorphisms (SNP) and psychosocial measures in the model only revealed significant SNPs after accounting for gene by social environment interactions. Methods: We sought to externally validate SNPs associated with BP in African Americans (AAs) identified in a study by Quinlan et al. in 2016 that incorporated novel measures of unfair treatment/discrimination and revealed new genes and biological pathways relevant to BP variation. Our validation was done using a larger cohort study of AAs, the Jackson Heart Study (JHS). Systolic and diastolic BP were measured twice in the same visit using a random-zero mercury sphygmomanometer and averaged. During this visit, perceived discrimination was assessed as lifetime occurrence of unfair treatment in nine social domains using the JHS discrimination instrument. Using available GWAS data, 28 significant SNPs were imputed from 1000 Genomes Project Phase 1 (version 3). Our analysis was conducted separately on participants who reported use of BP medications (n= 1532) and those who did not (n=1407). We similarly tested for associations of SNPs with BP using 3 linear regression models adjusting for global ancestry, sex, age, education, BMI, and relatedness. Model 1 tested only the SNPs, model 2 tested the SNPs and discrimination, and model 3 tested an interaction between SNPs and discrimination. Results: JHS participants were 62% female, with a mean age of 55 years, mean BMI of 32, mean systolic BP of 127 and mean diastolic BP of 76. Participants on average experienced unfair treatment in three domains in their lifetime. In participants not on BP medications, we found that rs2116737, in the gene SGCD , achieved Bonferroni-corrected significance (p 〈 0.004) with systolic BP in a recessive genotype model (β= 11.92; p =2.00х10 -4 ) and was only identified through model 3, the gene-discrimination interaction model. No significant findings were seen in patients using BP medications. Conclusions: rs2116737 was validated in the JHS for a gene-discrimination interaction. rs2116737 is an intronic variant in SGCD , a gene that is highly expressed in arterial tissue, suggesting vascular regulation as a possible mechanism behind the interaction. In conclusion, the findings suggest accounting for a gene by social environment interaction can identify new SNPs that deserve further investigation in understanding BP variation.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.139.suppl_1.P348
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 1466401-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation
    Springer Science and Business Media LLC ; 2017
    In:  Annals of Biomedical Engineering Vol. 45, No. 3 ( 2017-3), p. 644-655
    Details
    In: Annals of Biomedical Engineering, Springer Science and Business Media LLC, Vol. 45, No. 3 ( 2017-3), p. 644-655
    Type of Medium: Online Resource
    ISSN: 0090-6964 , 1573-9686
    URL: Article
    DOI: 10.1007/s10439-016-1725-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 1477155-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...