In:
The FEBS Journal, Wiley, Vol. 273, No. 21 ( 2006-11), p. 4842-4852
Abstract:
Caspase‐3 is a programmed cell death protease involved in neuronal apoptosis during physiological development and under pathological conditions. It is a promising therapeutic target for treatment of neurodegenerative diseases. We reported previously that isoquinoline‐1,3,4‐trione and its derivatives inhibit caspase‐3. In this report, we validate isoquinoline‐1,3,4‐trione and its derivatives as potent, selective, irreversible, slow‐binding and pan‐caspase inhibitors. Furthermore, we show that these inhibitors attenuated apoptosis induced by β‐amyloid(25–35) in PC12 cells and primary neuronal cells.
Type of Medium:
Online Resource
ISSN:
1742-464X
,
1742-4658
DOI:
10.1111/ejb.2006.273.issue-21
DOI:
10.1111/j.1742-4658.2006.05483.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2172518-4
SSG:
12
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