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  • 1
    In: Chemical Science, Royal Society of Chemistry (RSC), Vol. 14, No. 3 ( 2023), p. 506-513
    Abstract: The pathogenesis of Alzheimer's disease (AD) is closely related to several contributing factors, especially amyloid-β (Aβ) aggregation. Bioorthogonal reactions provide a general, facile, and robust route for the localization and derivatization of Aβ-targeted agents. Herein, a pair of chiral alkyne-containing metallohelices (ΛA and ΔA) were demonstrated to enantioselectively target and modulate Aβ aggregation, which has been monitored in triple-transgenic AD model mice and proved to improve cognitive function. Compared with its enantiomer ΔA, ΛA performed better in blocking Aβ fibrillation, relieving Aβ-triggered toxicity, and recovering memory deficits in vivo . Moreover, clickable ΛA could act as a functional module for subsequent visualization and versatile modification of amyloid via bioorthogonal reaction. As a proof-of-concept, thioflavin T, tacrine, and magnetic nanoparticles were conjugated with ΛA to realize Aβ photo-oxygenation, acetylcholinesterase inhibition, and Aβ clearance, respectively. This proof-of-principle work provided new insights into the biolabeling and bioconjugation of multifunctional metallosupramolecules through click reactions for AD therapy.
    Type of Medium: Online Resource
    ISSN: 2041-6520 , 2041-6539
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2559110-1
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  • 2
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Instrumentation and Measurement Vol. 72 ( 2023), p. 1-10
    In: IEEE Transactions on Instrumentation and Measurement, Institute of Electrical and Electronics Engineers (IEEE), Vol. 72 ( 2023), p. 1-10
    Type of Medium: Online Resource
    ISSN: 0018-9456 , 1557-9662
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 160442-9
    detail.hit.zdb_id: 2027532-8
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  • 3
    Online Resource
    Online Resource
    Royal Society of Chemistry (RSC) ; 2012
    In:  Chemical Communications Vol. 48, No. 46 ( 2012), p. 5787-
    In: Chemical Communications, Royal Society of Chemistry (RSC), Vol. 48, No. 46 ( 2012), p. 5787-
    Type of Medium: Online Resource
    ISSN: 1359-7345 , 1364-548X
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2012
    detail.hit.zdb_id: 1472881-3
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  • 4
    In: Cell & Bioscience, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-07-25)
    Abstract: The absence of prominent, actionable genetic alternations in osteosarcomas (OS) implies that transcriptional and epigenetic mechanisms significantly contribute to the progression of this life-threatening form of cancer. Therefore, the identification of potential transcriptional events that promote the survival of OS cells could be key in devising targeted therapeutic approaches for OS. We have previously shown that RUNX2 is a transcription factor (TF) essential for OS cell survival. Unfortunately, the transcriptional network or circuitry regulated by RUNX2 in OS cells is still largely unknown. Methods The TFs that are in the RUNX2 transcriptional circuitry were identified by analyzing RNAseq and ChIPseq datasets of RUNX2. To evaluate the effect of SOX9 knockdown on the survival of osteosarcoma cells in vitro, we employed cleaved caspase-3 immunoblotting and propidium iodide staining techniques. The impact of SOX9 and JMJD1C depletion on OS tumor growth was examined in vivo using xenografts and immunohistochemistry. Downstream targets of SOX9 were identified and dissected using RNAseq, pathway analysis, and gene set enrichment analysis. Furthermore, the interactome of SOX9 was identified using BioID and validated by PLA. Result Our findings demonstrate that SOX9 is a critical TF that is induced by RUNX2. Both in vitro and in vivo experiments revealed that SOX9 plays a pivotal role in the survival of OS. RNAseq analysis revealed that SOX9 activates the transcription of MYC , a downstream target of RUNX2. Mechanistically, our results suggest a transcriptional network involving SOX9, RUNX2, and MYC, with SOX9 binding to RUNX2. Moreover, we discovered that JMJD1C, a chromatin factor, is a novel binding partner of SOX9, and depletion of JMJD1C impairs OS tumor growth. Conclusion The findings of this study represent a significant advancement in our understanding of the transcriptional network present in OS cells, providing valuable insights that may contribute to the development of targeted therapies for OS.
    Type of Medium: Online Resource
    ISSN: 2045-3701
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2593367-X
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  • 5
    Online Resource
    Online Resource
    American Chemical Society (ACS) ; 2023
    In:  ACS Omega Vol. 8, No. 9 ( 2023-03-07), p. 8219-8226
    In: ACS Omega, American Chemical Society (ACS), Vol. 8, No. 9 ( 2023-03-07), p. 8219-8226
    Type of Medium: Online Resource
    ISSN: 2470-1343 , 2470-1343
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2023
    detail.hit.zdb_id: 2861993-6
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  • 6
    Online Resource
    Online Resource
    Emerald ; 2021
    In:  Internet Research Vol. 31, No. 4 ( 2021-07-12), p. 1236-1261
    In: Internet Research, Emerald, Vol. 31, No. 4 ( 2021-07-12), p. 1236-1261
    Abstract: Despite the prevalent use of professional status and service feedback in online healthcare markets, the potential interaction relationship between two types of information is still unknown. This study used the signaling theory to examine the substitute relationship between professional status and service feedback in patients' doctor choice, as well as the moderating effect of illness severity. Design/methodology/approach To test the paper's hypotheses, we constructed a panel data model using 418 doctors' data collected over a period of six months from an online healthcare market in China. Then, according to the results of the Hausman test, we estimated a fixed-effects model of patients' choice in online healthcare markets. Findings The empirical results showed that the effect of a doctor's professional status and service feedback on a patient's doctor choice was substitutable. Moreover, patients' illness severity played a moderating role, in that the influence of professional status on a patient with high-severity illness was higher than that on a patient with low-severity illness, whereas the influence of service feedback on a patient with low-severity illness was higher than that of a patient with high-severity illness. In addition, we found that illness severity negatively moderated the substitute relationship between professional status and service feedback on a patient's choice. Originality/value These findings not only contribute to signaling theory and research on online healthcare markets, but also help us understand the importance of professional status and service feedback on a patient's choice when seeking a doctor online.
    Type of Medium: Online Resource
    ISSN: 1066-2243
    Language: English
    Publisher: Emerald
    Publication Date: 2021
    detail.hit.zdb_id: 2012338-3
    SSG: 24,1
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  • 7
    Online Resource
    Online Resource
    International Oil Spill Conference ; 2017
    In:  International Oil Spill Conference Proceedings Vol. 2017, No. 1 ( 2017-05-01), p. 1006-1019
    In: International Oil Spill Conference Proceedings, International Oil Spill Conference, Vol. 2017, No. 1 ( 2017-05-01), p. 1006-1019
    Abstract: In-situ burning (ISB) is an important tool to remove oil from the environment. During ISB, it is important to know the volume reduction of oil for the overall accounting of the spilled oil, as a metric for operational decisions, and to account for the ISB portion of the oil budget. The burn rate depends on the type of oil, degree of emulsification and weathering, estimated thickness, weather conditions, and size of the burn area. Furthermore, each spill has a unique physical environment and oil properties that affect burn efficiency and rate. The volume of oil consumed during ISB is typically computed using a manual, coarse, time integration of the instantaneous burn area based on visual observations and a characteristic burn rate. The area is typically estimated in the field using known boom geometry and visual inspection of the fire-water interface, and recorded manually. We have developed methods to measure the instantaneous consumption of burning oil and thus the oil burn rate by integrating direct measurements of thickness using acoustics sensors in the water under the slick with direct measurements of the area of the burning oil using infrared and visible light images from cameras above the burning oil. Data were collected during the burning of several oils and petroleum products including ANS, rock, diesel, and hexane. The acoustic thickness measurement took into account the high temperature gradient in the oil and combined with multi camera automated burn area estimates yielded an instantaneous measurement of the volume of oil consumed while burning. We were able to identify the buildup of the burn, the active burning phase, and in the case of confined burns the vigorous burning phase. Knowing the instantaneous thickness and surface area during burning allowed us to directly calculate the burn rate and to study the dynamics of ISB. We are working on validating the burn rate and efficiency with direct measurements of the weight of the oil and residue before, during, and after burning. The authors believe these are the first direct measurements of slick thickness using acoustics during ISB.
    Type of Medium: Online Resource
    ISSN: 2169-3366 , 2169-3358
    Language: English
    Publisher: International Oil Spill Conference
    Publication Date: 2017
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Measurement and Control Vol. 56, No. 1-2 ( 2023-01), p. 133-146
    In: Measurement and Control, SAGE Publications, Vol. 56, No. 1-2 ( 2023-01), p. 133-146
    Abstract: Relative coupling control (RCC) structure is widely used for multi-motor speed synchronization control. To improve the performance of multi-motor synchronous control, artificial bee colony (ABC) algorithm is developed and applied for enhancing RCC structure. The RCC structure optimized by the ABC algorithm is called the RCC-ABC structure. In the RCC-ABC structure, the ABC algorithm optimizes both the fixed compensation factor in the speed compensator and the parameters of the PID controller acting as a tracking controller. Simulation experiments based on a four-motor system are conducted to validate the efficiency of the RCC-ABC structure. Simulation results show that the RCC-ABC structure has better synchronization and tracking performance compared to the RCC structure.
    Type of Medium: Online Resource
    ISSN: 0020-2940
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2712343-1
    SSG: 3,2
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  • 9
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2008
    In:  Acta Mechanica Solida Sinica Vol. 21, No. 6 ( 2008-12), p. 564-572
    In: Acta Mechanica Solida Sinica, Springer Science and Business Media LLC, Vol. 21, No. 6 ( 2008-12), p. 564-572
    Type of Medium: Online Resource
    ISSN: 0894-9166 , 1860-2134
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2008
    detail.hit.zdb_id: 2110783-X
    SSG: 6,25
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  • 10
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Materials Science: Materials in Electronics Vol. 33, No. 33 ( 2022-11), p. 25232-25238
    In: Journal of Materials Science: Materials in Electronics, Springer Science and Business Media LLC, Vol. 33, No. 33 ( 2022-11), p. 25232-25238
    Type of Medium: Online Resource
    ISSN: 0957-4522 , 1573-482X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2016994-2
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