In:
Arhiv za bioloske nauke, National Library of Serbia, Vol. 66, No. 4 ( 2014), p. 1673-1680
Abstract:
Although the model of cerebral hypoperfusion in rats has been a matter of
many investigations over the years, the exact intracellular and biochemical
mechanisms that lead to neuron loss and memory decline have not been clearly
identified. In the current study, we examined whether cerebral hypoperfusion
causes changes in hippocampal protein expression of apoptotic markers in the
synaptosomal fraction and neurodegeneration in a time-dependent and
sex-specific manner. Adult male and female Wistar rats were divided into two
main groups, controls that underwent sham operation, and animals subjected to
permanent bilateral occlusion of common carotid arteries. Both male and
female rats were killed 3, 7 or 90 days following the insult. The obtained
results indicate that the peak of processes that lead to apoptosis occured on
postoperative day 7 and that they were more prominent in males, indicating
that neuroprotective effects of certain substances (planned for future
experiments), should be tested at this time point.
Type of Medium:
Online Resource
ISSN:
0354-4664
,
1821-4339
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2014
detail.hit.zdb_id:
2380842-1
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