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  • 1
    In: OTA International, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 1 ( 2024-3-1)
    Abstract: To compare the rates of revision surgery for symptomatic neuromas in patients undergoing primary transtibial amputations with and without targeted muscle reinnervation (TMR). Design: Retrospective cohort study. Setting: Level I trauma hospital and tertiary military medical center. Patients/Participants: Adult patients undergoing transtibial amputations with and without TMR. Intervention: Transtibial amputation with targeted muscle reinnervation. Main Outcome Measurements: Reoperation for symptomatic neuroma. Results: During the study period, there were 112 primary transtibial amputations performed, 29 with TMR and 83 without TMR. Over the same period, there were 51 revision transtibial amputations performed, including 23 (21%) in the patients undergoing primary transtibial amputation at the study institution. The most common indications for revision surgery were wound breakdown/dehiscence (42%, n = 25), followed by symptomatic neuroma 18% (n = 9/51) and infection/osteomyelitis (17%, n = 10) as the most common indications. However, of the patients undergoing primary amputation at the study's institution, there was no difference in reoperation rates for neuroma when comparing the TMR group (3.6%, n = 1/28) and no TMR group (4.0%, n = 3/75) ( P = 0.97). Conclusions: Symptomatic neuroma is one of the most common reasons for revision amputation; however, this study was unable to demonstrate a difference in revision surgery rates for neuroma for patients undergoing primary transtibial amputation with or without targeted muscle reinnervation. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
    Type of Medium: Online Resource
    ISSN: 2574-2167
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 3019952-9
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  • 2
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  JBJS Open Access Vol. 6, No. 2 ( 2021-6-14)
    In: JBJS Open Access, Ovid Technologies (Wolters Kluwer Health), Vol. 6, No. 2 ( 2021-6-14)
    Abstract: Fragility fractures are often sentinel events in documenting new cases of osteoporosis. Numerous analyses have demonstrated low rates of adequate osteoporosis evaluation and treatment following primary fragility fractures. The purpose of this study was to quantify the incidence of primary fragility fractures in America and the rates of osteoporosis screening and management before and after fracture. Methods: A retrospective review of the PearlDiver database was conducted using the International Classification of Diseases, Ninth Revision (ICD-9) and ICD, Tenth Revision (ICD-10) and Current Procedural Terminology codes. Patients who were 60 to 80 years of age and had primary fragility fractures of the hip, wrist, spine, pelvis, humerus, and other unspecified locations were included. The rates of dual x-ray absorptiometry (DXA) screening and osteoporosis pharmacotherapy were assessed for 2 years before and 2 years after the primary fracture. Results: In this study, 48,668 patients with a primary fragility fracture were identified. Within this cohort, 25.8% (12,573 of 48,668) had received osteoporosis screening or treatment in the prior 2 years. In the 36,095 patients with no management before the fracture, 19% (6,799 patients) were diagnosed with osteoporosis and 18.4% (6,653 patients) received a DXA scan and/or filed claims for pharmacotherapy in the following 2 years. Patients with an osteoporosis diagnosis were more likely to receive both types of management (odds ratio [OR], 11.55 [95% confidence (CI), 10.31 to 12.95] ), and male patients were less likely to receive both types of management (OR, 0.23 [95% CI, 0.17 to 0.27]). Secondary fragility fractures within the next 2 years were diagnosed in 8.4% (3,038 of 36,095) of patients at a mean of 221 days following the primary fracture. Conclusions: The rates of appropriate osteoporosis evaluation, diagnosis, and management following primary fragility fractures remain unacceptably low. Less than one-third of patients with primary fragility fractures had been evaluated or treated for osteoporosis in the 2 years prior to fracture. Furthermore, among patients without pre-fracture management, 〈 20% received osteoporosis screening or treatment within the next 2 years. Level of Evidence: Prognostic Level IV . See Instructions for Authors for a complete description of levels of evidence.
    Type of Medium: Online Resource
    ISSN: 2472-7245
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2873843-3
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  • 3
    Online Resource
    Online Resource
    Elsevier BV ; 1983
    In:  Insect Biochemistry Vol. 13, No. 5 ( 1983-1), p. 453-468
    In: Insect Biochemistry, Elsevier BV, Vol. 13, No. 5 ( 1983-1), p. 453-468
    Type of Medium: Online Resource
    ISSN: 0020-1790
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1983
    detail.hit.zdb_id: 2197401-9
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  • 4
    Online Resource
    Online Resource
    Data Trace Publishing Company ; 2012
    In:  Journal of Surgical Orthopaedic Advances Vol. 21, No. 02 ( 2012), p. 88-91
    In: Journal of Surgical Orthopaedic Advances, Data Trace Publishing Company, Vol. 21, No. 02 ( 2012), p. 88-91
    Type of Medium: Online Resource
    ISSN: 1548-825X
    Language: English
    Publisher: Data Trace Publishing Company
    Publication Date: 2012
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  • 5
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Journal of the American Academy of Orthopaedic Surgeons Vol. 30, No. 2 ( 2022-01-15), p. e204-e212
    In: Journal of the American Academy of Orthopaedic Surgeons, Ovid Technologies (Wolters Kluwer Health), Vol. 30, No. 2 ( 2022-01-15), p. e204-e212
    Abstract: Rates of osteoporosis evaluation and management after primary fragility fractures have remained low in recent years. The extent to which this treatment gap affects patients with diabetes is unclear. This study aimed to compare the risk of secondary fractures and rates of osteoporosis diagnosis and management after sentinel fractures in patients with and without diabetes. Methods: A propensity score–matched cohort study was conducted using the PearlDiver database. Patients aged 50 years and older with primary fragility fractures of the hip, wrist, spine, pelvis, humerus, and other locations were identified. Rates of secondary fractures, dual radiograph absorptiometry (DXA) scans, charted osteoporosis diagnoses (International Classification of Diseases, Ninth and Tenth Revisions), and osteoporosis pharmacotherapy within 2 years were compared for patients with and without diabetes using multivariable logistic regression. Results: Matching yielded 27,052 patients in each cohort. Index humerus fractures were more common in the diabetic cohort (15.0% versus 11.6%, P 〈 0.001), whereas wrist fractures were more prevalent among the nondiabetic cohort (15.2% versus 19.3%, P 〈 0.001). Incidence of secondary fractures at 2 years was higher for diabetic patients than nondiabetic patients (5.2% versus 4.7%; odds ratio [OR] 1.08; 95% confidence interval [CI] , 0.99 to 1.17). Diabetic patients were significantly less likely to receive a DXA scan (13.2% versus 13.5%; OR 0.93; 95% CI, 0.88 to 0.98), be diagnosed with osteoporosis (9.3% versus 11.9%; OR 0.77; 95% CI, 0.73 to 0.82), or start pharmacotherapy (8.1% versus 8.7; OR 0.93; 95% CI, 0.87 to 0.99). Conclusion: Despite diabetes being a well-established risk factor for fragility fractures, diabetic patients were significantly less likely to receive DXA scan evaluation, be formally diagnosed with osteoporosis, or be treated with osteoporosis pharmacotherapy after a sentinel fragility fracture. Incidence of secondary fractures within 2 years was also higher among diabetic patients.
    Type of Medium: Online Resource
    ISSN: 1067-151X , 1940-5480
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
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  • 6
    In: Foot & Ankle Orthopaedics, SAGE Publications, Vol. 4, No. 2 ( 2019-04-01), p. 247301141983883-
    Abstract: Osteochondral lesions of the talus (OLTs) are common injuries in young, active patients. Microfracture is an effective treatment for lesions less than 150 mm 2 in size. Most commonly employed postoperative protocols involve delaying weightbearing for 6 to 8 weeks (DWB), though one study suggests that early weightbearing (EWB) may not be detrimental to patient outcomes. The goal of this research is to compare outcomes following EWB and DWB protocols after microfracture for OLTs. Methods: We performed a prospective, randomized, multicenter clinical trial of subjects with unilateral, primary, unifocal OLTs treated with microfracture. Thirty-eight subjects were randomized into EWB (18 subjects) and DWB (20 subjects) at their first postsurgical visit. The EWB group began unrestricted WB at that time, whereas the DWB group were instructed to remain strictly nonweightbearing for an additional 4 weeks. Primary outcome measures were the American Academy of Orthopaedic Surgery (AAOS) Foot and Ankle score and numeric rating scale (NRS) pain score. Results: The EWB group demonstrated significant improvement in AAOS Foot and Ankle Questionnaire scores at the 6-week follow-up appointment as compared to the DWB group (83.1 ± 13.5 vs 68.7 ± 15.8, P = .017). Following this point, there were no significant differences in AAOS scores between groups. At no point were NRS pain scores significantly different between the groups. Conclusions: EWB after microfracture for OLTs was associated with improved AAOS scores in the short term. Thereafter and through 2 years’ follow-up, no statistically significant differences were seen between EWB and DWB groups. Level of Evidence: Level II, prospective randomized trial.
    Type of Medium: Online Resource
    ISSN: 2473-0114 , 2473-0114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2874570-X
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  • 7
    Online Resource
    Online Resource
    Oxford University Press (OUP) ; 1983
    In:  Journal of Economic Entomology Vol. 76, No. 4 ( 1983-08-01), p. 700-703
    In: Journal of Economic Entomology, Oxford University Press (OUP), Vol. 76, No. 4 ( 1983-08-01), p. 700-703
    Type of Medium: Online Resource
    ISSN: 1938-291X , 0022-0493
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1983
    detail.hit.zdb_id: 2477182-X
    detail.hit.zdb_id: 2030999-5
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Elsevier BV ; 1987
    In:  Pesticide Biochemistry and Physiology Vol. 28, No. 1 ( 1987-5), p. 9-16
    In: Pesticide Biochemistry and Physiology, Elsevier BV, Vol. 28, No. 1 ( 1987-5), p. 9-16
    Type of Medium: Online Resource
    ISSN: 0048-3575
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1987
    detail.hit.zdb_id: 1471454-1
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    SLACK, Inc. ; 2022
    In:  Orthopedics Vol. 45, No. 4 ( 2022-07), p. 244-250
    In: Orthopedics, SLACK, Inc., Vol. 45, No. 4 ( 2022-07), p. 244-250
    Abstract: In response to increasing rates of self-reported latex allergies, changes have been made to prevent anaphylaxis in the operating room, including the use of latex-free gloves. However, the impact of these changes on the risk of prosthetic joint infection (PJI) after arthroplasty is unclear. This study evaluated whether documented latex allergy is an independent risk factor for PJI and aseptic revision surgery after total hip arthroplasty (THA) and total knee arthroplasty (TKA). A retrospective matched cohort study was conducted with an administrative claims database. A total of 17,501 patients who underwent TKA and had documented latex allergy were matched 1:4 with 70,004 control subjects, and 8221 patients who underwent THA and had documented latex allergy were matched 1:4 with 32,884 control subjects. Multivariable logistic regression showed that patients who had TKA and had a latex allergy showed significantly higher risk of PJI at both 90 days (odds ratio [OR], 1.26) and 1 year (OR, 1.22) and significantly higher risk of aseptic revision TKA at 1 year (OR, 1.21) after surgery compared with control subjects. Patients who had THA and had a latex allergy had significantly higher risk of PJI at 1 year (OR, 1.19) compared with control subjects. Rates of aseptic revision THA were higher in the latex allergy cohort but statistically comparable ( P 〉 .05). Latex allergy was associated with significantly increased risk of PJI and aseptic revision after TKA and significantly increased risk of PJI after THA. More work is needed to determine whether these risks can be mitigated or if latex allergy is an inherent, nonmodifiable risk factor requiring modification to typical arthroplasty pathways. [ Orthopedics . 2022;45(4):244–250.]
    Type of Medium: Online Resource
    ISSN: 0147-7447 , 1938-2367
    Language: English
    Publisher: SLACK, Inc.
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    American Chemical Society (ACS) ; 1986
    In:  Journal of Agricultural and Food Chemistry Vol. 34, No. 3 ( 1986-05), p. 444-447
    In: Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), Vol. 34, No. 3 ( 1986-05), p. 444-447
    Type of Medium: Online Resource
    ISSN: 0021-8561 , 1520-5118
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 1986
    detail.hit.zdb_id: 1483109-0
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