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  • 1
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Introduction: The long-term effects of catheter ablation (CA) compared to medical therapy on cardiovascular outcomes for atrial fibrillation (AF) remain undetermined. We examined the outcomes associated with CA compared to rate or rhythm control therapy in a population cohort with AF. Methods: Using Alberta administrative data, patients with AF as the primary diagnosis during hospitalization or emergency department/physician visit were included between 2008-2018. Based on therapy received, patients were assigned to CA, rate (digoxin, calcium channel or beta blocker) or rhythm control (amiodarone, sotalol, flecainide, propafenone, dronedarone). If treatment changed over time, the patient was censored in the prior treatment arm and assigned to the new arm. The association of treatment (included as time-varying covariate) with the primary composite outcome of death, hospitalization for heart failure or stroke was examined using multivariable Cox models after adjusting for age, sex, comorbidities and baseline medications. Secondary outcomes included cardiovascular hospitalizations, and individual components of the composite. Results: There were 2,149 (4.0%) patients treated with CA and 51,315 with medical treatment (rate : 41,948, (81.5%) rhythm: 9,367 (18.2%). During a median follow-up of 4.2 years, CA for AF was associated with a lower crude incidence of the composite outcome (rate per 100 person-years was 3.3 for CA, 9.5 for rate control, and 6.3 for rhythm control). In multivariate analysis, compared to CA, both rate (adjusted hazard ratio (aHR) 1.55, 95% confidence interval (CI), 1.44 to 1.68) and rhythm control (aHR 1.37; 95% CI 1.27 to 1.49) were associated with a higher risk of the primary composite outcome.(Figure) Secondary outcomes are shown in the Figure. Conclusions: Only a small percentage of patients with AF undergo CA. Patients selected for CA have a lower risk of long-term adverse outcomes compared to medical therapy in patients with AF.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 2
    In: Journal of Diabetes, Wiley, Vol. 8, No. 1 ( 2016-01), p. 45-55
    Abstract: 我们评估了2005‐11年加拿大亚伯达省妊娠前存在的糖尿病(preexisting diabetes mellitus,pre‐DM)与妊娠糖尿病(GDM)的患病率以及妊娠结局。 方法 研究纳入了327198名单胎妊娠以及5552名双胎妊娠并且最终分娩活胎或者死胎的孕妇。将pre‐DM与非糖尿病孕妇相比,GDM与非糖尿病孕妇相比,评估了她们的不良结局优势比,并且按照母亲的特征进行了校正。 结果 妊娠合并糖尿病的比例为6.3%,合并GDM的比例为88%。在单胎妊娠中,pre‐DM以及GDM都与孕妇发生先兆子痫(校正后的优势比[aOR]分别为3.38、1.83)、剖宫产(aOR分别为2.53、1.55)、自发性早产(aOR分别为4.20、1.71)以及劳动诱发早产(aOR分别为3.82、2.00)的风险增加有关,并且都与婴儿出现巨大儿(aOR分别为2.11、1.30)、肩难产(aOR分别为1.54、1.32)、先天异常(aOR分别为1.61、1.20)以及入住新生儿重症监护治疗病房(aOR分别为3.81、1.60)的风险增加有关。另外,与非糖尿病孕妇相比较,pre‐DM还与死胎(aOR为3.73)以及新生儿死亡(aOR为2.00)的可能性增加有关。在双胎妊娠中,pre‐DM与自发性早产(aOR为3.54)、劳动诱发早产(aOR为3.57)、过期妊娠胎儿(aOR为3.73)、先天异常(aOR为3.05)以及入住新生儿重症监护治疗病房(aOR为2.91)的风险增加有关;GDM与先兆子痫(aOR为1.54)、剖宫产(aOR为1.57)以及过期妊娠胎儿(aOR为1.63)的风险增加有关。 结论 与GDM相比较,妊娠前存在糖尿病导致的风险更高。在单胎妊娠与双胎妊娠中,糖尿病与不良结局有关,并且与单胎妊娠相比,双胎妊娠增加的风险通常都相似或者更少,这可能与她们的“基线”风险更高并且临床监测更紧密有关。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2485432-3
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  • 3
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. Suppl_1 ( 2022-11-08)
    Abstract: Introduction: Socioeconomic status (SES) and remoteness of residence (RoR) impact access to care and outcomes in congenital (CHD) and acquired (AHD) pediatric heart disease. Whether the universal, centralized Canadian healthcare system mitigates such inequities is unclear. We examined associations between SES and RoR on age at cardiac diagnosis (ACD), time to first intervention (TFI), and annual primary care (PCV) and cardiology (CV) visits as evidence of healthcare access in Alberta. Methods: All children born and diagnosed in Alberta with CHD or AHD from 2005-2017 were included. CHD was classified as mild, moderate, and severe base on the Bethesda Task Force definitions. Geospatial modelling was used to determine drive times ( 〈 60, 60-180, 〉 180 minutes) to 1 of 2 provincial cardiac programs. Cox proportional hazards regression models were used to examine relationships between RoR and SES with ACD and TFI, and Poisson models using generalized estimating equations for annual PCV and CV. Results: Of 12,542 children, 9347 had mild, 1733 moderate and 717 severe CHD and 745 AHD. Most (8,833, 70.4%) lived 〈 60 minutes to a cardiac center, and the largest proportion were in SES quintile 1 (least vulnerable, 3,074, 24.5%) and smallest in quintile 5 (most vulnerable, 2003, 16.0%). Median ACD was 1(IQR 0-108) days for mild, 0(0-54) days for moderate, and 0(0-0) days for severe CHD, and 340(41-1312) days for AHD. Intervention occurred in 1086(62.7%) with moderate CHD (TFI 63(7-150) days), 588(82.0%) with severe CHD (11(5-58) days), and 42 with AHD (1828(793-2866) days). ACD was impacted slightly by SES and only in AHD (Table). TFI and PCVs were not impacted by RoR or SES. Finally, CVs were inversely related to RoR for CHD and AHD. Conclusions: In Alberta, SES and RoR do not importantly impact ACD, TFI and PCVs among CHD and AHD patients. Greater RoR but not SES, however, is associated with fewer annual CVs, suggesting a need to optimize cardiac outreach services.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 1466401-X
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  • 4
    Online Resource
    Online Resource
    UCLA Asian American Studies Center ; 2011
    In:  AAPI Nexus: Policy, Practice and Community Vol. 9, No. 1-2 ( 2011-09), p. 249-255
    In: AAPI Nexus: Policy, Practice and Community, UCLA Asian American Studies Center, Vol. 9, No. 1-2 ( 2011-09), p. 249-255
    Type of Medium: Online Resource
    ISSN: 1545-0317
    Language: English
    Publisher: UCLA Asian American Studies Center
    Publication Date: 2011
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  • 5
    Online Resource
    Online Resource
    UCLA Asian American Studies Center ; 2011
    In:  AAPI Nexus Journal: Policy, Practice, and Community Vol. 9, No. 1-2 ( 2011), p. 249-255
    In: AAPI Nexus Journal: Policy, Practice, and Community, UCLA Asian American Studies Center, Vol. 9, No. 1-2 ( 2011), p. 249-255
    Abstract: Using data from the National Center for Health Statistics, an assessment was performed on the quality of death reporting in accordance with standards, a working definition was developed, death counts and rates for several racial categories were analyzed, and data was modeled for use in data structures optimized for analysis and reporting with simple client tools. Most states were still not compliant with the 1997 Office of Management and Budget racial categories by 2005. Comparing the mortality experience of NHOPI to whites revealed many differences. Mortality was higher in NHOPI males and occurred at younger ages for both males and females. The place of death differed between NHOPI and whites, while place of injury (where applicable) was similar. Causes also varied after the top two causes of death.
    Type of Medium: Online Resource
    URL: Issue
    Language: Unknown
    Publisher: UCLA Asian American Studies Center
    Publication Date: 2011
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