In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 2 ( 2023-2-22), p. e0282153-
Abstract:
There is ample epidemiological and animal-model evidence suggesting that intestinal inflammation is associated with the development of Parkinson’s disease (PD). Leucine-rich α2 glycoprotein (LRG) is a serum inflammatory biomarker used to monitor the activity of autoimmune diseases, including inflammatory bowel diseases. In this study, we aimed to investigate whether serum LRG could be used a biomarker of systemic inflammation in PD and to help distinguish disease states. Serum LRG and C-reactive protein (CRP) levels were measured in 66 patients with PD and 31 age-matched controls. We found that serum LRG levels were statistically significantly higher in the PD group than in the control group (PD: 13.9 ± 4.2 ng/mL, control: 12.1 ± 2.7 ng/mL, p = 0.036). LRG levels were also correlated with Charlson comorbidity index (CCI) and CRP levels. LRG levels in the PD group were correlated with Hoehn and Yahr stages (Spearman’s r = 0.40, p = 0.008). LRG levels were statistically significantly elevated in PD patients with dementia as compared to those without dementia (p = 0.0078). Multivariate analysis revealed a statistically significant correlation between PD and serum LRG levels after adjusting for serum CRP levels, and CCI (p = 0.019). We conclude that serum LRG levels could be considered a potential biomarker for systemic inflammation in PD.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0282153
DOI:
10.1371/journal.pone.0282153.g001
DOI:
10.1371/journal.pone.0282153.g002
DOI:
10.1371/journal.pone.0282153.t001
DOI:
10.1371/journal.pone.0282153.t002
DOI:
10.1371/journal.pone.0282153.t003
DOI:
10.1371/journal.pone.0282153.t004
DOI:
10.1371/journal.pone.0282153.s001
DOI:
10.1371/journal.pone.0282153.s002
DOI:
10.1371/journal.pone.0282153.s003
DOI:
10.1371/journal.pone.0282153.s004
DOI:
10.1371/journal.pone.0282153.s005
DOI:
10.1371/journal.pone.0282153.s006
DOI:
10.1371/journal.pone.0282153.r001
DOI:
10.1371/journal.pone.0282153.r002
DOI:
10.1371/journal.pone.0282153.r003
DOI:
10.1371/journal.pone.0282153.r004
DOI:
10.1371/journal.pone.0282153.r005
DOI:
10.1371/journal.pone.0282153.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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