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  • 1
    In: Nature Energy, Springer Science and Business Media LLC, Vol. 8, No. 2 ( 2023-01-12), p. 159-168
    Type of Medium: Online Resource
    ISSN: 2058-7546
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2847369-3
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  • 2
    Online Resource
    Online Resource
    Royal Society of Chemistry (RSC) ; 2020
    In:  Nanoscale Vol. 12, No. 10 ( 2020), p. 6089-6095
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 12, No. 10 ( 2020), p. 6089-6095
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2020
    detail.hit.zdb_id: 2515664-0
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Immunology Vol. 14 ( 2023-8-30)
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-8-30)
    Abstract: While targeted systemic inflammatory modulators show promise in preventing chronic kidney disease (CKD) progression, the causal link between specific inflammatory factors and CKD remains uncertain. Methods Using a genome-wide association study of 41 serum cytokines from 8,293 Finnish individuals, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis. In addition, we genetically predicted causal associations between inflammatory factors and 5 phenotypes, including CKD, estimated glomerular filtration rate (eGFR), dialysis, rapid progression of CKD, and rapid decline in eGFR. Inverse variance weighting (IVW) served as the primary MR method, while MR-Egger, weighted median, and MR-pleiotropy residual sum and outlier (MR-PRESSO) were utilized for sensitivity analysis. Cochrane’s Q test for heterogeneity. Leave-one-out method ensured stability of MR results, and Bonferroni correction assessed causal relationship strength. Results Seventeen cytokines were associated with diverse renal outcomes. Among them, after Bonferroni correction test, higher tumor necrosis factor alpha levels were associated with a rapid decrease in eGFR (OR = 1.064, 95% CI 1.028 – 1.103, P = 0.001), higher interleukin-4 levels were associated with an increase in eGFR (β = 0.003, 95% CI 0.001 – 0.005, P = 0.002), and higher growth regulated oncogene alpha (GROα) levels were associated with an increased risk of CKD (OR=1.035, 95% CI 1.012 - 1.058, P = 0.003). In contrast, genetic susceptibility to CKD was associated with an increase in GROa, and a decrease in eGFR may lead to an increase in stem cell factor. We did not find the presence of horizontal pleiotropy during the analysis. Conclusion We discovered causally related inflammatory factors that contribute to the initiation and progression of CKD at the genetic prediction level.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2606827-8
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Endocrinology Vol. 14 ( 2023-2-28)
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 14 ( 2023-2-28)
    Abstract: Observational studies have identified a possible link between thyroid function and diabetic microangiopathy, specifically in diabetic kidney disease (DKD) and diabetic retinopathy (DR). However, it is unclear whether this association reflects a causal relationship. Objective To assess the potential direct effect of thyroid characteristics on DKD and DR based on Mendelian randomization (MR). Methods We conducted an MR study using genetic variants as an instrument associated with thyroid function to examine the causal effects on DKD and DR. The study included the analysis of 4 exposure factors associated with thyroid hormone regulation and 5 outcomes. Genomewide significant variants were used as instruments for standardized freethyroxine (FT4) and thyroid-stimulating hormone (TSH) levels within the reference range, standardized free triiodothyronine (FT3):FT4 ratio, and standardized thyroid peroxidase antibody (TPOAB) levels. The primary outcomes were DKD and DR events, and secondary outcomes were estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (ACR) in diabetes, and proliferative diabetic retinopathy (PDR). Satisfying the 3 MR core assumptions, the inverse-variance weighted technique was used as the primary analysis, and sensitivity analysis was performed using MR-Egger, weighted median, and MR pleiotropy residual sum and outlier techniques. Results All outcome and exposure instruments were selected from publicly available GWAS data conducted in European populations. In inverse-variance weighted random-effects MR, gene-based TSH with in the reference range was associated with DKD (OR 1.44; 95%CI 1.04, 2.41; P = 0.033) and eGFR (β: -0.031; 95%CI: -0.063, -0.001; P = 0.047). Gene-based increased FT3:FT4 ratio, decreased FT4 with in the reference range were associated with increased ACR with inverse-variance weighted random-effects β of 0.178 (95%CI: 0.004, 0.353; P = 0.046) and -0.078 (95%CI: -0.142, -0.014; P = 0.017), respectively, and robust to tests of horizontal pleiotropy. However, all thyroid hormone instruments were not associated with DR and PDR at the genetic level. Conclusion In diabetic patients, an elevated TSH within the reference range was linked to a greater risk of DKD and decreased eGFR. Similarly, decreased FT4 and an increased FT3:FT4 ratio within the reference range were associated with increased ACR in diabetic patients. However, gene-based thyroid hormones were not associated with DR, indicating a possible pathway involving the thyroid-islet-renal axis. However, larger population studies are needed to further validate this conclusion.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2592084-4
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  • 5
    In: Journal of Diabetes and its Complications, Elsevier BV, Vol. 37, No. 6 ( 2023-06), p. 108477-
    Type of Medium: Online Resource
    ISSN: 1056-8727
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2006763-X
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  • 6
    In: European Journal of Inorganic Chemistry, Wiley, Vol. 2019, No. 47 ( 2019-12-19), p. 5000-5007
    Abstract: (NH 4 )In 3 (SO 4 ) 2 (OH) 6 , a new indium incorporated synthetic compound belonging to the alunite supergroup, is successfully prepared by hydrothermal reaction. The crystal structure is determined by single‐crystal X‐ray diffraction. (NH 4 )In 3 (SO 4 ) 2 (OH) 6 crystallizes in space group R 3 m of a = b = 7.69(8) Å, c = 17.71(2) Å and Z = 3, and it adopts a layered structure with alternating corrugated two‐dimensional 2 ∞ [In 3 (SO 4 ) 2 (OH) 6 – ] anionic network and interstitial NH 4 + ions. The measurements of X‐ray powder diffraction pattern, Fourier transform infrared spectroscopy spectrum, differential Scanning Calorimeter and X‐ray photoelectron spectroscopy have been performed on this new compound. The title compound is air‐ and water‐stable and starts thermal decomposition to In 2 O 3 at 620 K. Interstitial NH 4 + ions between two‐dimensional 2 ∞ [In 3 (SO 4 ) 2 (OH) 6 – ] layers are exchangeable by cations like Pb 2+ . The maximum adsorption capacity of Pb 2+ ions reaches 990 mg/g at pH 6.5, and the selectivity is observed with a very high distribution coefficient K d of 1.1 × 10 6  mL/g compared with other completive cations. The unique layered framework composed of [InO 6 ] 9– octahedra and [SO 4 ] 2– tetrahedra is chemically stable to enable excellent cycling performance. This investigation will advocate the alunite supergroup minerals for efficient and recyclable adsorption of toxic metal ions in contaminated water.
    Type of Medium: Online Resource
    ISSN: 1434-1948 , 1099-0682
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1475009-0
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  • 7
    In: Small, Wiley, Vol. 16, No. 5 ( 2020-02)
    Abstract: Exploring the origin of transition metal (TM) lattice‐doped layered double hydroxides (LDHs) toward the oxygen evolution reaction (OER) plays a crucial role in engineering efficient electrocatalysts. Without understanding the physics behind the TM‐induced catalytic enhancements, it would be challenging to design the next generation of electrocatalysts. Herein, single Ru atoms are introduced into a CoCr LDHs lattice to improve activity. In 0.1 m KOH, CoCrRu LDHs require only 290 mV overpotential to drive to 10 mA cm −2 and show a Tafel slope of 56.12 mV dec −1 . Electronic structure analyses based on density functional theory confirm that promoted OER activity originates from synergetic charge transfer among Ru, Cr, and Co elements. Specifically, Ru dopants can downshift d states of Co and enhance electron donation of Cr to oxygenates, which essentially breaks the scaling relation and achieves higher activity. This work provides insights into how single atomic Ru dopant tunes the electronic structures of its neighbor's active site Co and thus increases OER activities.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2168935-0
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  • 8
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-1-12), p. 1-12
    Abstract: Background. Diabetic kidney disease (DKD) is the most important cause of the end-stage renal disease (ESRD) and the main cause of renal replacement therapy. Excessive inflammatory response and renal fibrosis are the keys to the development of this disease, and the conventional Western medical treatment is difficult to achieve and obtain long-term stable clinical results in all patients with DKD. Many studies have shown that Chinese medicine as a complementary and alternative medicine may be another therapeutic option to mitigate the progression of DKD to ESRD. In recent years, many doctors have used the Bushen Huoxue therapy to assist Western medicine in the treatment of the disease and have achieved certain clinical effects. However, most of the current studies are small sample studies, and there is no evidence-based confirmation. Objective. To systematically evaluate the efficacy and safety of the Bushen Huoxue therapy combined with conventional Western medicine in the treatment of DKD. Methods. A comprehensive search of literature databases such as CNKI, Wanfang, Pubmed, and Cochrane Library was conducted. The screening condition was that the control group was treated with conventional Western medicine and the experimental group was treated with Bushen Huoxue therapy’s RCT on top of the control group, and the RCTs were published from January 2011 to October 2021. The Cochrane risk bias assessment tool was used for literature quality evaluation, and RevMan 5.3 software was used for statistical analysis. Results. A total of 23 RCTs were finally included, with a total of 2,105 patients. Meta-analysis results show that the experimental group can effectively improve the clinical efficacy (RR = 1.28, 95% CI (1.22, 1.34), P 〈 0.01 ), significantly reduce Crea (SMD = −0.45, 95% CI (−0.57, −0.33), P 〈 0.01 ), 24 h UTP (SMD = −0.57, 95% CI (−0.69, −0.45), P 〈 0.01 ), BUN (SMD = −0.36, 95%CI (−0.48, −0.24), P 〈 0.01 ), UAER (SMD = −1.58, 95% CI (−1.78, −1.37), P 〈 0.01 ), and blood sugar, and have certain medication safety (RR = 0.00, 95% CI (−0.03, 0.03), P = 0.87 ). Conclusions. Chinese medicine based on the Bushen Huoxue therapy has a good clinical effect in the treatment of diabetic kidney disease and has certain safety. However, due to the limitation of the quality and quantity of the included literature, the above conclusion still needs more rational experiments to further verify.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 9
    In: Advanced Functional Materials, Wiley, Vol. 30, No. 21 ( 2020-05)
    Abstract: Recent advances in layered TiS 3 has shown appealing potential for photoelectrochemical hydrogen evolution due to its excellent optical and electronic properties. Here, an excellent photoanode, composed of TiS 3 nanoribbon arrays with moderate S 2 2− vacancies, is proposed to achieve efficient photoelectrochemical hydrogen evolution. These unique S 2 2− vacancies are introduced in the TiS 3 photoanode by a simple vacuum re‐annealing method, which is inspired by crystal structure analyses of TiS 3 and TiS 2 . The existing S 2 2− vacancies are revealed to significantly promote the electron conductivity, charge separation, and transport of the photoanode simultaneously. The resulting TiS 3− x photoanode with ≈22% S 2 2− vacancies exhibits a twofold increase in the electron diffusion length for efficient electron collection and a remarkably high photocurrent density of 15.35 mA cm −2 at 1.4 V versus reversible hydrogen electrode.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 10
    In: Chemistry – A European Journal, Wiley, Vol. 28, No. 23 ( 2022-04-22)
    Abstract: Polyvinyl chloride (PVC) is widely used in daily life, but its waste has become a serious environmental problem. A solid base assisted low‐temperature solvothermal dehalogenation was developed in this work to sustainably and efficiently transform PVC into high‐value dimethylamine hydrochloride (DMACl) chemical and N,O co‐doped carbon monolith with hierarchically porous structure. The synergistic promotion of solid‐base catalyst and solvent decomposition with the removal of HCl can shift forward the chemical equilibrium to promote the dechlorination of PVC and increase the carbon yield. Meanwhile, the solid‐base catalyst can also act as a pore‐forming additive to fabricate the carbon monolith with hierarchical pores. Induced by the high specific surface area, hierarchical pores and N,O co‐doped structure, the generated carbon monolith exhibits superior electrocatalytic performance towards H 2 evolution. These discoveries shed light on the design of synergistically coupled solvent and solid catalyst to promote the heterogeneous conversion of waste chlorinated plastics into high‐value chemicals for a sustainable future.
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1478547-X
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