In:
Journal of the World Aquaculture Society, Wiley, Vol. 49, No. 6 ( 2018-12), p. 1058-1067
Abstract:
Pharmacokinetics of florfenicol were studied in the orange‐spotted grouper, Epinephelus coioides , at 29.0 ± 1.0 C following oral administration of 5 or 10 mg/kg. Rapid absorption occurred, with a T max (time to reach the maximum concentration) of 2–12 h in plasma, muscle, skin, liver, bile, intestine, kidney, and gill. The absorption rate appeared to decrease with increasing dosage, according to the observed T max in plasma, muscle, skin, liver, and kidney. The maximum concentration ( C max ) in plasma was 6.04 ± 1.11 and 13.01 ± 6.18 μg/mL at 5 and 10 mg/kg, respectively, and was lower than that in the intestine but higher than in the other six tissues. A similar absorption and availability was found between the two doses by comparison of the ratios of area under the concentration–time curve (AUC) and dose among the tissues. A relatively low distribution level occurred in extravascular tissues based on the AUC values, with the exception of bile and intestine. The shortest and longest elimination half‐life ( T 1/2β ) occurred in plasma (8.51 and 9.34 h at 5 and 10 mg/kg) and bile (18.13 and 17.63 h at 5 and 10 mg/kg), respectively. The elimination rate from plasma, muscle, and kidney was more rapid at 5 than at 10 mg/kg, according to the T 1/2β ; however, the opposite situation was observed in the remaining five tissues.
Type of Medium:
Online Resource
ISSN:
0893-8849
,
1749-7345
DOI:
10.1111/jwas.2018.49.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2233509-2
SSG:
21,3
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