In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 10 ( 2023-10-4), p. e0291950-
Abstract:
System x c - , encoded by Slc7a11 , is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and the formation of thiol peptides, such as glutathione. Glutathione acts as a co-factor for enzymes responsible for scavenging reactive oxygen species. Upon exposure to bacterial products, macrophages exhibit a rapid upregulation of system x c - . This study investigates the impact of Slc7a11 deficiency on the functionality of peritoneal and bone marrow-derived macrophages. Our findings reveal that the absence of Slc7a11 results in significantly reduced glutathione levels, compromised mitochondrial flexibility, and hindered cytokine production in bone marrow-derived macrophages. Conversely, system x c - has a lesser impact on peritoneal macrophages in vivo . These results indicate that system x c - is essential for maintaining glutathione levels, mitochondrial functionality, and cytokine production, with a heightened importance under atmospheric oxygen tension.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0291950
DOI:
10.1371/journal.pone.0291950.g001
DOI:
10.1371/journal.pone.0291950.g002
DOI:
10.1371/journal.pone.0291950.g003
DOI:
10.1371/journal.pone.0291950.g004
DOI:
10.1371/journal.pone.0291950.g005
DOI:
10.1371/journal.pone.0291950.t001
DOI:
10.1371/journal.pone.0291950.s001
DOI:
10.1371/journal.pone.0291950.r001
DOI:
10.1371/journal.pone.0291950.r002
DOI:
10.1371/journal.pone.0291950.r003
DOI:
10.1371/journal.pone.0291950.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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