In:
Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 143, No. 7-8 ( 2015), p. 429-437
Abstract:
Introduction. At present, two phylogenetically distinct influenza B virus
lineages, B/Yamagata and B/ Victoria, co-circulate worldwide and can cause
significant morbidity and mortality. Objective. The aim of this study was to
determine the prevalences of two influenza B virus lineages in the population
of Vojvodina and to identify their antigenic and phylogenetic properties.
Methods. A total of 369 and 334 nasopharyngeal, or nasal/throat swab samples,
collected during the 2012/2013 and 2013/2014 seasons, respectively, were
tested using specific singleplex influenza A, influenza B, influenza
B/Yamagata and influenza B/Victoria real-time reverse transcription
polymerase chain reaction (RT-PCR) assays. Antigenic and genetic testing were
done by hemagglutination inhibition assay and hemagglutinin and neuraminidase
gene sequence analysis, respectively. Results. During the 2012/2013 season,
influenza B viruses were present in 53.4% (101/189) of influenza positive
samples. The B/Yamagata-like viruses (81.2%) significantly predominated over
the B/Victoria-like viruses (18.8%). Comparing to B/Victoria-like positive
patients, among B/Yamagata-like positive patients, children 5-14 years of age
were significantly more represented (5.3% vs. 35.4%, respectively), as well
as patients with mild form of illness (15.8% vs. 45.1%, respectively). The
results of sequence analysis and antigenic testing showed that tested viruses
were not closely related to B/Wisconsin/1/2010, the vaccine virus for
2012/2013. During the 2013/2014 season influenza B viruses were not detected.
Conclusion. The results of this study confirmed the health significance of
influenza B viruses and indicated that B/Yamagata-like viruses were
significantly more prevalent than B/Victoria lineage viruses, during the
2012/2013 season. They also showed a sub-optimal match between the tested
viruses and the vaccine virus for season 2012/2013.
Type of Medium:
Online Resource
ISSN:
0370-8179
,
2406-0895
DOI:
10.2298/SARH1508429R
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2015
detail.hit.zdb_id:
2577665-4
Permalink