In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 9 ( 2023-9-20), p. e0291755-
Abstract:
Long-lasting insecticidal bed nets (LLINs) are a key measure for preventing malaria and their evaluation is coordinated by the World Health Organization Pesticide Evaluation Scheme (WHOPES). LifeNet ® was granted WHOPES time-limited interim recommendation in 2011 after successful Phase I and Phase II evaluations. Here, we evaluated the durability and community acceptance of LifeNet ® in a Phase III trial from June 2014 to June 2017 in Benin rural area. Methods A prospective longitudinal, cluster-randomized, controlled trial with households as the unit of observation was designed to assess the performance of LifeNet® over a three-year period, using a WHOPES fully recommended LLIN (PermaNet ® 2.0) as a positive control. The primary outcomes were the bioassay performance using WHO cone assays and tunnel tests, the insecticide content and physical integrity. Results At baseline, 100% of LLINs were within the tolerance limits of their target deltamethrin concentrations. By 36 months only 17.3% of LifeNet ® and 8.5% of PermaNet ® LLINs still were within their target deltamethrin concentrations. Despite these low rates, 100% of both LLINs meet WHO efficacy criteria (≥ 80% mortality or ≥ 95% knockdown or tunnel test criteria of ≥ 80% mortality or ≥ 90% blood-feeding inhibition) after 36 months using WHO cone bio-assays and tunnel tests. The proportion of LLINs in good physical condition was 33% for LifeNet ® and 29% for PermaNet ® after 36 months. After 36 M the survivorship was 21% and 26% for LifeNet® and PermaNet® respectively. Although both LLINs were well accepted by the population, complaints of side effects were significantly higher among LifeNet ® users than PermaNet ® ones. Conclusion LifeNet ® LLINs did meet WHO criteria for bio-efficacy throughout the study period and were well accepted by the population. This is an important step towards getting a full WHO recommendation for use in malaria endemic countries.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0291755
DOI:
10.1371/journal.pone.0291755.g001
DOI:
10.1371/journal.pone.0291755.g002
DOI:
10.1371/journal.pone.0291755.g003
DOI:
10.1371/journal.pone.0291755.g004
DOI:
10.1371/journal.pone.0291755.t001
DOI:
10.1371/journal.pone.0291755.t002
DOI:
10.1371/journal.pone.0291755.t003
DOI:
10.1371/journal.pone.0291755.t004
DOI:
10.1371/journal.pone.0291755.t005
DOI:
10.1371/journal.pone.0291755.t006
DOI:
10.1371/journal.pone.0291755.t007
DOI:
10.1371/journal.pone.0291755.s001
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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