In:
Molecular Oncology, Wiley, Vol. 6, No. 1 ( 2012-02), p. 33-47
Kurzfassung:
First report highlighting the role and mechanism by which shRNA against uPA/uPAR inhibits angiogenesis in glioblastoma. shRNA against uPA/uPAR enhances secretion of sVEGFr1, a scavenger for VEGF. sVEGFr1 secretion is independent of GM‐CSF unlike monocytes but dependent on TIMP‐1. TIMP‐1 secretion is mediated by MMP‐7 which is further regulated by uPA and uPAR.
Materialart:
Online-Ressource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1016/j.molonc.2011.11.008
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2012
ZDB Id:
2322586-5
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