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  • 1
    Online Resource
    Online Resource
    Renoprotective effect of calcium channel blockers
    National Library of Serbia ; 2009
    In:  Srpski arhiv za celokupno lekarstvo Vol. 137, No. 11-12 ( 2009), p. 690-696
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 137, No. 11-12 ( 2009), p. 690-696
    Abstract: Napredovanje hronicne slabosti bubrega je u najvecoj meri posledica sekundarnih hemodinamskih i metabolickih faktora, kao sto su intraglomerulska hipertenzija i glomerulska hipertrofija. Iako je kontrola krvnog pritiska osnovni mehanizam prevencije razvoja slabosti bubrega, inhibitori angiotenzin-konvertujuceg enzima (ACE-inhibitori) i blokatori AT1 receptora za angiotenzin II imaju dodatne mehanizme kojima ostvaruju preventivno dejstvo. Stoga ovi lekovi tradicionalno imaju prednost u lecenju svih osoba s oboljenjima bubrega, pogotovu bolesnika s proteinurijom izmedju 400 i 1000 mg. Iako su ranije eksperimentalne studije ukazale na renoprotektivno dejstvo antagonista kalcijuma (blokatora kalcijumovih kanala, kalcijumskih antagonista), klinicke studije nisu potvrdile njihovu prednost u odnosu na inhibitore sistema renin-angiotenzin, bilo da se primenjuju u vidu monoterapije ili kombinovane terapije s ACE-inhibitorima. To je objasnjeno dejstvom antagonista kalcijuma prevashodno na aferentnu, ali ne i na eferentnu arteriolu, sto je imalo za posledicu intraglomerulsku hipertenziju. Novije generacije dihidropiridinskih antagonista kalcijuma imaju svojstva dilatiranja i eferentne arteriole, te stoga nemaju nepovoljan ucinak na hemodinamiku bubrega. Ovo je potvrdjeno i klinickim radovima kojima je pokazana renoprotektivna uloga dihidropiridinskih antagonista kalcijuma koji nisu bili inferiorni u odnosu na ACE-inhibitore i koji su imali dodatno povoljno dejstvo na renoprotekciju kada se s njima kombinuju. Dejstvom i na aferentnu i na eferentnu arteriolu, kao i drugim pleotropnim efektima, dihidropiridinski antagonisti kalcijuma novije generacije izgleda da nude nove terapijske mogucnosti u zastiti bubrega.
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH0912690D
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2009
    detail.hit.zdb_id: 2577665-4
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  • 2
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    Vascular access calcification predicts mortality in hemodialysis patients
    Elsevier BV ; 2008
    In:  Kidney International Vol. 74, No. 12 ( 2008-12), p. 1582-1587
    Details
    In: Kidney International, Elsevier BV, Vol. 74, No. 12 ( 2008-12), p. 1582-1587
    Type of Medium: Online Resource
    ISSN: 0085-2538
    URL: Article
    DOI: 10.1038/ki.2008.458
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2008
    detail.hit.zdb_id: 2007940-0
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  • 3
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    A modern approach to a geriatric patient: Half a century of geriatric medicine in Serbia
    Centre for Evaluation in Education and Science (CEON/CEES) ; 2014
    In:  Medicinska istrazivanja Vol. 48, No. 1 ( 2014), p. 48-50
    Details
    In: Medicinska istrazivanja, Centre for Evaluation in Education and Science (CEON/CEES), Vol. 48, No. 1 ( 2014), p. 48-50
    Abstract: What is specific about the modern approach to geriatric patients? First of all, it is the approach to elderly patients, whose primary target is not a particular disease or the treatment of a system of organs, but the treatment of the entire person. If our interdisciplinary team's knowledge and efforts do result in healing an elderly person, we do not consider ourselves successful unless there is a complete recovery or, in other words, unless the elderly patient is back on their feet. The modern approach to geriatric patients is based on 50 - year experience in clinical work with elderly patients, as well as on fundamental science, but it also applies current trends in the treatment of common diseases (e.g. the final stage of renal disease, arterial hypertension, diabetes). Finally, the approach is completed with specificities in treating elderly patients - i.e. focus on iatrogenesis and the application of geriatric assessment in everyday geriatric practice.
    Type of Medium: Online Resource
    ISSN: 0301-0619
    Uniform Title: Savremen pristup gerijatrijskom pacijentu - pola veka gerijatrijske medicine u Srbiji
    URL: Article
    DOI: 10.5937/MedIst1401048D
    Language: English
    Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
    Publication Date: 2014
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  • 4
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    Risk Factors for Cardiovascular Calcifications in Non-Diabetic Caucasian Haemodialysis Patients
    S. Karger AG ; 2009
    In:  Kidney and Blood Pressure Research Vol. 32, No. 3 ( 2009), p. 161-168
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 32, No. 3 ( 2009), p. 161-168
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 Dialysis patients display an increased mortality which is associated with cardiovascular calcifications. Diabetes mellitus and ethnicity are known factors that affect the extent of cardiovascular calcifications. However, most studies have investigated mixed cohorts with diabetics and/or mixed ethnicity. 〈 i 〉 Methods: 〈 /i 〉 Cardiovascular calcifications were assessed in non-diabetic Caucasian haemodialysis patients by the semiquantitative Adragao calcification score (X-ray pelvis and hands) and a novel composite calcification score encompassing the Adragao score as well as calcifications detected by X-ray of the fistula arm, echocardiography of heart valves and carotid ultrasound. 〈 i 〉 Results: 〈 /i 〉 Using multivariate analysis, age, male gender, dialysis vintage, lower Kt/V, calcium-phosphate product, smoking and high-sensitivity CRP were independent risk factors for cardiovascular calcifications as assessed by the Adragao or the composite score. Pulse wave velocity was independently related to both calcification scores. Body mass index, cholesterol, triglycerides, iPTH and serum levels of fetuin-A and uncarboxylated matrix Gla protein were not associated with cardiovascular calcifications. 〈 i 〉 Conclusions: 〈 /i 〉 In our cohort of non-diabetic Caucasian haemodialysis patients, age, male gender, dialysis vintage, smoking, calcium-phosphate product, high-sensitivity CRP and lower Kt/V were independent risk factors for cardiovascular calcifications. Whether lowering the calcium-phosphate product and increasing dialysis efficiency can reduce cardiovascular calcifications in dialysis patients remains to be determined.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000221064
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2009
    detail.hit.zdb_id: 1482922-8
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  • 5
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    Hyperkalemia in hypertensive patients undergoing regular hemodialysis during enalapril and fosinopril therapy
    National Library of Serbia ; 2006
    In:  Srpski arhiv za celokupno lekarstvo Vol. 134, No. 1-2 ( 2006), p. 44-48
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 134, No. 1-2 ( 2006), p. 44-48
    Abstract: Uvod. Hipertenzija se javlja kod 80-85% bolesnika s hronicnom slaboscu bubrega, a medikamentna terapija je indikovana kod 25-30% bolesnika. Pored antihipertenzivnog efekta, inhibitori angiotenzin- konvertujuceg enzima znacajno smanjuju hipertrofiju leve komore i mortalitet dijaliznih bolesnika. I pored toga, njihova primena je ogranicena usled akumulacije i potencijalne hiperkalemije izmedju dve dijalize. Cilj rada. Cilj rada je bio da se uporedi efekat fozinoprila i enalaprila na vrednost kalijuma u serumu kod bolesnika s hipertenzijom koji se lece hronicnim hemodijalizama. Metod rada Studija je obuhvatila 16 bolesnika prosecne starosti od 58,9?9,6 godina sa prosecnim trajanjem hipertenzije od 11,3?7,1 godine. Efekat komparativnih doza antihipertenzivnih lekova na vrednosti kalijuma u serumu ispitan je tokom tromesecnih perioda: perioda 1 (enalapril), perioda 2 (fozinopril) i perioda 3 (enalapril). Kod bolesnika nije bilo znakova infekcije ni drugih oboljenja, a laboratorijske analize su radjene jednom mesecno. Rezultati, prikazani kao srednje vrednosti sa standardnom devijacijom, medjusobno su poredjeni metodom ANOVA za ponavljana merenja, a razlike parova varijabli izmedju pojedinih rezima ispitane su po Bonferonijevom metodu. Rezultati. Utvrdjena je statisticki znacajna razlika u srednjim vrednostima kalijuma u serumu po terapijskim rezimima (5,88?0,38 prema 4,99?0,44 prema 5,46?0,46 mmol/l; p〈0,001). Razlika je bila ocigledna vec tokom prvog meseca primene fozinoprila. Ovaj efekat se ne moze objasniti efikasnijom dijalizom jer se vrednosti Kt/V nisu razlikovale izmedju posmatranih perioda (1,18?0,24 prema 1,25?0,21 prema 1,25?0,14; p nije znacajno). Sistolni krvni pritisak je bio znacajno bolje regulisan primenom fozinoprila (160,0?20 mm Hg prema 187,5?21,4 mm Hg; p=0,01) i taj efekat je bio produzen i u periodu 3. Vrednost hemoglobina je zavisila od specificne terapije za lecenje anemije, a manje od vrste primenjenog ACE inhibitora. Zakljucak. Kod bolesnika s hipertenzijom koji su na hronicnom programu lecenja hemodijalizama fozinopril dovodi do manjeg rizika od hiperkalemije nego enalapril. Iako definitivni zakljucci zahtevaju dobro dizajnirane studije na vecem broji bolesnika, navedeni podaci ukazuju na prednost fozinoprila kod bolesnika s hipertenzijom koji su skloni hiperkalemiji u medjudijaliznom periodu.
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH0602044D
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2006
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  • 6
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    The cardio-renal anemia syndrome
    National Library of Serbia ; 2007
    In:  Medical review Vol. 60, No. 7-8 ( 2007), p. 357-363
    Details
    In: Medical review, National Library of Serbia, Vol. 60, No. 7-8 ( 2007), p. 357-363
    Abstract: Cilj ovog preglednog clanka jeste da ukaze na problem anemije u hronicnoj srcanoj insuficijenciji i hronicnim bolestima bubrega koji je dugo smatran klinicki beznacajnim. Novija istrazivanja u poslednjoj dekadi pokazala su da to nije tacno i da problem anemije u hronicnoj srcanoj insuficijenciji treba posmatrati u okviru novog definisanog entiteta koji se oznacava kao sindrom kardio-renalne anemije. Ovaj sindrom ukazuje na interakcije izmedju hronicne srcane insuficijencije-hronicne bubrezne insuficijencije i anemije zasnovane na principu pozitivne povratne sprege. U radu su prikazani moguci patofizioloski mehanizmi nastanka ovog sindroma, epidemioloske karakteristike i terapijski rezultati dosadasnjih istrazivanja. Retrospektivne studije a potom prospektivne kontrolisane studije pokazale su da lecenje anemije supkutano aplikovanog rekombinavanog humanog eritropoetina i intravensko davanje preparata gvozdja u trajanju 3-6 meseci dovodi do: subjektivnog poboljsanja u smislu smanjenja ucestalosti i intenziteta simptoma (uz poboljsanje funkcionalne klase odredjene po preporukama New York Heart Association); povecanja ejekcione frakcije leve komore; smanjenja mortaliteta; smanjenja broja rehospitalizacija uz smanjenje broja dana hospitalnog lecenja; smanjenja doza lekova koji se koriste kao dokazana "klasicna terapija"(narocito diuretika) i poboljsanja bubrezne funkcije. .
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS0708357D
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2007
    detail.hit.zdb_id: 2381028-2
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  • 7
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    Polymorphism of angiotensin converting enzyme in hemodialysis patients-association with cardiovascular morbidity
    National Library of Serbia ; 2014
    In:  Medical review Vol. 67, No. 9-10 ( 2014), p. 297-304
    Details
    In: Medical review, National Library of Serbia, Vol. 67, No. 9-10 ( 2014), p. 297-304
    Abstract: nema
    Type of Medium: Online Resource
    ISSN: 0025-8105 , 1820-7383
    URL: Article
    DOI: 10.2298/MPNS1410297T
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2014
    detail.hit.zdb_id: 2381028-2
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  • 8
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    Genetic polymorphisms of paraoxonase 1 and susceptibility to atherogenesis
    National Library of Serbia ; 2013
    In:  Srpski arhiv za celokupno lekarstvo Vol. 141, No. 9-10 ( 2013), p. 629-633
    Details
    In: Srpski arhiv za celokupno lekarstvo, National Library of Serbia, Vol. 141, No. 9-10 ( 2013), p. 629-633
    Abstract: Introduction. Paraoxonase 1 (PON1) is a multifunctional enzyme associated with high-density lipoprotein particles (HDL). It is a cellular antioxidant that hydrolyses oxidized macromolecules, especially low-density lipoproteins (ox-LDL). Because increased oxidative stress is believed to play a crucial role in the initiation and propagation of atherosclerosis, coding (Q192R and L55M) and promoter (C(-107)T) region polymorphisms of pon1 gene, that are responsible for catalytic efficiency, activity and the level of the enzyme, have been of great interest as a potential markers of susceptibility for atherogenesis. Objective. The aim of the study was to assess possible association between these pon1 gene variants and clinical manifestations of the atherosclerosis and oxidative stress. Methods. A total of 60 angiographically documented patients with manifested atherosclerotic disease and 100 control individuals were analyzed. Genomic DNA was isolated from the peripheral blood cells and genotyping was performed using polymerase chain reaction followed by the restriction fragment length polymorphism (PCR-RFLP) analysis. Results No significant difference in allele and genotype frequencies of all three examined polymorphisms was found between the atherosclerotic patients and healthy controls. The obtained results could not support an association of pon1 gene variants with the oxidative stress and atherogenesis. Conclusion. These polymorphisms cannot be considered risk factors of atherosclerosis in Serbian population. A larger study is required in order to establish possible contribution of pon1 variants to atherosclerosis-related cardiovascular diseases.
    Type of Medium: Online Resource
    ISSN: 0370-8179 , 2406-0895
    URL: Article
    DOI: 10.2298/SARH1310629G
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2577665-4
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  • 9
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    Cytogenetic Analyses Reveal “Atypical Cells” in the Peritoneal Dialysis Effluent
    SAGE Publications ; 1994
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 14, No. 2 ( 1994-04), p. 159-162
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 14, No. 2 ( 1994-04), p. 159-162
    Abstract: Cytogenetic analyses were performed on dividing cells from the peritoneal effluent of 26 patients undergoing chronic peritoneal dialysis (CPD). Numerical and structural abnormalities of karyotype served as the diagnostic criteria for “atypical cells.” The following cytogenetic abnormalities were observed in 7 patients: hyperdiploidy (in 6 patients), hypodiploidy (in 2 patients), and marker chromosomes (in 2 patients). In 3 patients more than one chromosome abnormality was present. Dividing cells with normal mitoses were observed in 11 patients, while in the remaining 8 patients no dividing cells could be found. There were no differences in age, sex, duration of dialysis, and peritonitis incidence between patients with pathological mitoses and those without it. The question whether this unexpected finding is a consequence of immunosuppressed uremic status, dialysis procedure, or some other factor remains to be elucidated.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/089686089401400212
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1994
    detail.hit.zdb_id: 2075957-5
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  • 10
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    Achievement of guideline targets in elderly patients on hemodialysis: a multicenter study
    Springer Science and Business Media LLC ; 2015
    In:  International Urology and Nephrology Vol. 47, No. 9 ( 2015-9), p. 1555-1563
    Details
    In: International Urology and Nephrology, Springer Science and Business Media LLC, Vol. 47, No. 9 ( 2015-9), p. 1555-1563
    Type of Medium: Online Resource
    ISSN: 0301-1623 , 1573-2584
    URL: Article
    DOI: 10.1007/s11255-015-1055-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2015547-5
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