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  • 1
    In: European Heart Journal, Oxford University Press (OUP), Vol. 41, No. 5 ( 2020-02-01), p. 655-720
    Type of Medium: Online Resource
    ISSN: 0195-668X , 1522-9645
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2001908-7
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2010
    In:  International Journal of Heat and Mass Transfer Vol. 53, No. 17-18 ( 2010-8), p. 3429-3438
    In: International Journal of Heat and Mass Transfer, Elsevier BV, Vol. 53, No. 17-18 ( 2010-8), p. 3429-3438
    Type of Medium: Online Resource
    ISSN: 0017-9310
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 240652-4
    detail.hit.zdb_id: 2012726-1
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  • 3
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2013
    In:  Journal of Fluid Mechanics Vol. 718 ( 2013-03-10), p. 89-115
    In: Journal of Fluid Mechanics, Cambridge University Press (CUP), Vol. 718 ( 2013-03-10), p. 89-115
    Abstract: The physical mechanism by which large-scale vortical structures augment convective heat transfer is a fundamental problem of turbulent flows. To investigate this phenomenon, two separate experiments were performed using simultaneous heat transfer and flow field measurements to study the vortex–wall interaction. Individual vortices were identified and studied both as part of a turbulent stagnation flow and as isolated vortex rings impacting on a surface. By examining the temporal evolution of both the flow field and the resulting heat transfer, it was observed that the surface thermal transport was governed by the transient interaction of the vortical structure with the wall. The magnitude of the heat transfer augmentation was dependent on the instantaneous strength, size and position of the vortex relative to the boundary layer. Based on these observations, an analytical model was developed from first principles that predicts the time-resolved surface convection using the transient properties of the vortical structure during its interaction with the wall. The analytical model was then applied, first to the simplified vortex ring model and then to the more complex stagnation region experiments. In both cases, the model was able to accurately predict the time-resolved convection resulting from the vortex interactions with the wall. These results reveal the central role of large-scale turbulent structures in the augmentation of thermal transport and establish a simple model for quantitative predictions of transient heat transfer.
    Type of Medium: Online Resource
    ISSN: 0022-1120 , 1469-7645
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2013
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    detail.hit.zdb_id: 218334-1
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  • 4
    Online Resource
    Online Resource
    ASME International ; 2012
    In:  Journal of Biomechanical Engineering Vol. 134, No. 8 ( 2012-08-01)
    In: Journal of Biomechanical Engineering, ASME International, Vol. 134, No. 8 ( 2012-08-01)
    Abstract: Analytical solutions were developed based on the Green’s function method to describe heat transfer in tissue including the effects of blood perfusion. These one-dimensional transient solutions were used with a simple parameter estimation technique and experimental measurements of temperature and heat flux at the surface of simulated tissue. It was demonstrated how such surface measurements can be used during step changes in the surface thermal conditions to estimate the value of three important parameters: blood perfusion (wb), thermal contact resistance (R″), and core temperature of the tissue (Tcore). The new models were tested against finite-difference solutions of thermal events on the surface to show the validity of the analytical solution. Simulated data was used to demonstrate the response of the model in predicting optimal parameters from noisy temperature and heat flux measurements. Finally, the analytical model and simple parameter estimation routine were used with actual experimental data from perfusion in phantom tissue. The model was shown to provide a very good match with the data curves. This demonstrated the first time that all three of these important parameters (wb, R″, and Tcore) have simultaneously been estimated from a single set of thermal measurements at the surface of tissue.
    Type of Medium: Online Resource
    ISSN: 0148-0731 , 1528-8951
    Language: English
    Publisher: ASME International
    Publication Date: 2012
    SSG: 31
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  • 5
    Online Resource
    Online Resource
    ASME International ; 2010
    In:  Journal of Heat Transfer Vol. 132, No. 3 ( 2010-03-01)
    In: Journal of Heat Transfer, ASME International, Vol. 132, No. 3 ( 2010-03-01)
    Abstract: The development and evaluation of a novel hybrid method for obtaining heat flux measurements is presented. By combining the spatial and temporal temperature measurements of a heat flux sensor, the time response, accuracy, and versatility of the sensor is improved. Sensors utilizing the hybrid method are able to make heat flux measurements on both high and low conductivity materials. It is shown that changing the thermal conductivity of the backing material four orders of magnitude causes only an 11% change in sensor response. The hybrid method also increases the time response of heat flux sensors. The temporal response is shown to increase by up to a factor of 28 compared with a standard spatial sensor. The hybrid method is tested both numerically and experimentally on both high and low conductivity materials and demonstrates significant improvement compared with operating the sensor as a spatial or temporal sensor alone.
    Type of Medium: Online Resource
    ISSN: 0022-1481 , 1528-8943
    Language: English
    Publisher: ASME International
    Publication Date: 2010
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  • 6
    In: Heart, BMJ, Vol. 104, No. 1 ( 2018-01), p. 37-44
    Abstract: Patients with Ebstein’s anomaly of the tricuspid valve (EA) are at risk of tachyarrhythmia, congestive heart failure and sudden cardiac death. We sought to determine the value of cardiovascular magnetic resonance (CMR) for predicting these outcomes. Methods Seventy-nine consecutive adult patients (aged 37±15 years) with unrepaired EA underwent CMR and were followed prospectively for a median 3.4 (range 0.4–10.9) years for clinical outcomes, namely major adverse cardiovascular events (MACEs: sustained ventricular tachycardia/heart failure hospital admission/cardiac transplantation/death) and first-onset atrial tachyarrhythmia (AT). Results CMR-derived variables associated with MACE (n=6) were right ventricular (RV) or left ventricular (LV) ejection fraction (EF) (HR 2.06, 95% CI 1.168 to 3.623, p=0.012 and HR 2.35, 95% CI 1.348 to 4.082, p=0.003, respectively), LV stroke volume index (HR 2.82, 95% CI 1.212 to 7.092, p=0.028) and cardiac index (HR 1.71, 95% CI 1.002 to 1.366, p=0.037); all remained significant when tested solely for mortality. History of AT (HR 11.16, 95% CI 1.30 to 95.81, p=0.028) and New York Heart Association class 〉 2 (HR 7.66, 95% CI 1.54 to 38.20, p=0.013) were also associated with MACE; AT preceded all but one MACE, suggesting its potential role as an early marker of adverse outcome (p=0.011). CMR variables associated with first-onset AT (n=17; 21.5%) included RVEF (HR 1.55, 95% CI 1.103 to 2.160, p=0.011), total R/L volume index (HR 1.18, 95% CI 1.06 to 1.32, p=0.002), RV/LV end diastolic volume ratio (HR 1.55, 95% CI 1.14 to 2.10, p=0.005) and apical septal leaflet displacement/total LV septal length (HR 1.03, 95% CI 1.00 to 1.07, p=0.041); the latter two combined enhanced risk prediction (HR 6.12, 95% CI 1.67 to 22.56, p=0.007). Conclusion CMR-derived indices carry prognostic information regarding MACE and first-onset AT among adults with unrepaired EA. CMR may be included in the periodic surveillance of these patients.
    Type of Medium: Online Resource
    ISSN: 1355-6037 , 1468-201X
    Language: English
    Publisher: BMJ
    Publication Date: 2018
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  • 7
    In: Heart, BMJ, Vol. 106, No. 14 ( 2020-07), p. 1052-1058
    Abstract: The systemic right ventricle (SRV), defined as the morphological right ventricle supporting the systemic circulation, is relatively common in congenital heart disease (CHD). Our review aimed at examining the current evidence, knowledge gaps and technical considerations regarding implantable cardiac electronic device therapy in patients with SRV. The risk of sinus node dysfunction (SND) after atrial switch repair and/or complete heart block in congenitally corrected transposition of great arteries requiring permanent pacing increases with age. Similar to acquired heart disease, indication for pacing includes symptomatic bradycardia, SND and high degree atrioventricular nodal block. Right ventricular dysfunction and heart failure also represent important complications in SRV patients. Cardiac resynchronisation therapy (CRT) has been proposed to improve systolic function in SRV patients, although indications for CRT are not well defined and its potential benefit remains uncertain. Amongst adult CHD, patients with SRV are at the highest risk for sudden cardiac death (SCD). Nevertheless, risk stratification for SCD is scarce in this cohort and implantable cardioverter-defibrillator indication is currently limited to secondary prevention. Vascular access and the incidence of device-related complications, such as infections, inappropriate shocks and device system failure, represent additional challenges to implantable cardiac electronic device therapy in patients with SRV. A multidisciplinary approach with tertiary expertise and future collaborative research are all paramount to further the care for this challenging nonetheless ever increasing cohort of patients.
    Type of Medium: Online Resource
    ISSN: 1355-6037 , 1468-201X
    Language: English
    Publisher: BMJ
    Publication Date: 2020
    detail.hit.zdb_id: 2378689-9
    detail.hit.zdb_id: 1475501-4
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  • 8
    In: Heart, BMJ, Vol. 102, No. Suppl 1 ( 2016-03), p. A27.2-A27
    Type of Medium: Online Resource
    ISSN: 1355-6037 , 1468-201X
    Language: English
    Publisher: BMJ
    Publication Date: 2016
    detail.hit.zdb_id: 2378689-9
    detail.hit.zdb_id: 1475501-4
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  • 9
    Online Resource
    Online Resource
    ASME International ; 2013
    In:  Journal of Medical Devices Vol. 7, No. 3 ( 2013-09-01)
    In: Journal of Medical Devices, ASME International, Vol. 7, No. 3 ( 2013-09-01)
    Abstract: A new thermal perfusion probe operates by imposing a thermal event on the tissue surface and directly measuring the temperature and heat flux response of the tissue with a small sensor. The thermal event is created by convectively cooling the surface with a small group of impinging jets using room temperature air. The hypothesis of this research is that this sensor can be used to provide practical burn characterization of depth and severity by determining the thickness of nonperfused tissue. To demonstrate this capability the measurement system was tested with a phantom tissue that simulates the blood perfusion of tissue. Different thicknesses of plastic were used at the surface to mimic layers of dead tissue. A mathematical model developed by Alkhwaji et al. (2012, “New Mathematical Model to Estimate Tissue Blood Perfusion, Thermal Contact Resistance and Core Temperature,” ASME J. Biomech. Eng., 134, p. 081004) is used to determine the effective values of blood perfusion, core temperature, and thermal resistance from the thermal measurements. The analytical solutions of the Pennes bioheat equation using the Green's function method is coupled with an efficient parameter estimation procedure to minimize the error between measured and analytical heat flux. Seven different thicknesses of plastic were used along with three different flow rates of perfusate to simulate burned skin of the phantom perfusion system. The resulting values of thermal resistance are a combination of the plastic resistance and thermal contact resistance between the sensor and plastic surface. Even with the uncertainty of sensor placement on the surface, the complete set of thermal resistance measurements correlate well with the layer thickness. The values are also nearly independent of the flow rate of the perfusate, which shows that the parameter estimation can successfully separate these two parameters. These results with simulated burns show the value of this minimally invasive technique to measure the thickness of nonperfused layers. This will encourage further work with this method on actual tissue burns.
    Type of Medium: Online Resource
    ISSN: 1932-6181 , 1932-619X
    Language: English
    Publisher: ASME International
    Publication Date: 2013
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  • 10
    Online Resource
    Online Resource
    American Institute of Aeronautics and Astronautics (AIAA) ; 2012
    In:  Journal of Thermophysics and Heat Transfer Vol. 26, No. 3 ( 2012-07), p. 430-438
    In: Journal of Thermophysics and Heat Transfer, American Institute of Aeronautics and Astronautics (AIAA), Vol. 26, No. 3 ( 2012-07), p. 430-438
    Type of Medium: Online Resource
    ISSN: 0887-8722 , 1533-6808
    Language: English
    Publisher: American Institute of Aeronautics and Astronautics (AIAA)
    Publication Date: 2012
    detail.hit.zdb_id: 2037166-4
    detail.hit.zdb_id: 2026174-3
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